"Kofetamin": instructions for use, analogues, photos, reviews

Migraine is a neurological disorder characterized by regular or episodic painful and severe pain attacks that occur in one half of the head. This condition of the patient is not associated with serious injuries, stroke or brain tumors. Pulsating nature and intensity of pains are explained by the presence of vascular pathologies, and not by excessive strain of the patient.

It should also be noted that headaches with migraine are not associated with a sharp decrease or increase in blood pressure, an attack of ICP or glaucoma.

To treat this condition, very many specialists recommend using the drug "Kofetamin". Instructions for use, photo medications, reviews about it, similar tools and properties are presented below.

Composition of the drug, its form of release and packaging

What form does the drug "Kofetamin" have? Instructions for use, testimonials indicate that this product is on sale in the form of tablets. They include ingredients such as ergotamine tartrate, potato starch, stearic acid, talc, caffeine, glucose and sugar.

In the sale of medicines comes in contour mesh packaging.

Pharmacodynamic features of the drug

What is remarkable about tablets "Kofetamin"? Instructions for use indicate that this combination of agents, the effect of which is due to the properties of the constituent ingredients.

Caffeine promotes stimulation of the vasomotor and respiratory centers, and also increases excitation of the cerebral cortex. In addition, this substance has a cardiotonic effect. It slightly increases blood pressure, and also increases the frequency of breathing and cardiac contractions. Also, caffeine reduces drowsiness, stimulates motor activity, eliminates the feeling of fatigue, improves overall performance.

The severity and duration of this component depends on the state of the person, the type of nervous system and the activity of the whole organism.

In small doses, caffeine has a stimulating effect, and in large doses it has a depressing effect on the central nervous system.

As for ergotamine, it has a vasoconstrictive effect.

Kinetic features

Where is the absorption of such a drug as "Kofetamin"? Instructions for use indicate that this drug is quite good and very quickly absorbed from the intestine. Ergotamine binds 98% to plasma proteins, and caffeine - by 35%.

The greatest concentration of this drug in the blood is observed after 2 hours after taking the pill. Most of the caffeine is oxidized and demethylated, and then excreted along with the urine.

The metabolism of ergotamine is carried out in the liver with the formation of active derivatives.

This drug is excreted mainly with bile within five hours.

Indications for taking medication tablets

Do you know about the purpose for which the drug "Kofetamin" can be prescribed? Instruction, reviews report that such a drug is very effective in the vaso-paralytic form of migraine, arterial hypotension, as well as in vascular, infectious and traumatic lesions of the central nervous system, is used to reduce intracranial pressure.

Prohibitions to use the medicine

When should you not prescribe the drug "Kofetamin"? The instruction (analogues of the medication are listed below) informs that this remedy is forbidden to be taken at high sensitivity to the drug, as well as during the period of gestation and during lactation.

With caution, this medication is used for severe sleep disorders, arterial hypertension, vascular and heart diseases (eg, angina pectoris, severe atherosclerosis, paroxysmal tachycardia, myocardial infarction, peripheral vascular disease), glaucoma, anxiety and panic disorder, kidney or liver disease, agoraphobia And in old age.

The drug "Kofetamin": instructions for use

Analogues of this medicine should be prescribed only by a doctor. This is due to the fact that they can have completely different forms of output and methods of application.

This medication should be used during severe attacks of headache. In this case, it is prescribed in the amount of 1-2 tablets twice a day. After that, for several days, the medication is taken with 1 tablet with the same multiplicity.

It is strictly forbidden to exceed the maximum single dose of the drug, equal to 2 tablets, and the daily, equal to 4.

It should also be noted that you should not take this medication for a long time. After a week of taking the drug, you need to take a break for 4 days.

Adverse events

What are the possible side effects you should know before taking "Kofetamine" tablets? The instruction of this drug reports that it can cause the following reactions:

• Cardialgia, dizziness, hypertension, agitation;
• Tachycardia, headache, restlessness, pruritus, anxiety, tremor, reflex intensification, nausea, insomnia;
• Diarrhea, convulsions, vomiting, paresthesia in the extremities, edema.

With prolonged medication, it is possible to develop myalgia, a general sensitivity disorder in the lower extremities, and weakness.

Overdose and drug interaction

What signs of overdose occur when taking elevated doses of a drug such as Cofetamine? Instructions for use say that in this case the patient manifests: drowsiness, nausea, blocking, vomiting, numbness of the upper and lower extremities, stupor, as well as epileptic seizures and coma. To eliminate such phenomena, gastric lavage is performed. Also, the patient is assigned activated charcoal.

This drug enhances the effect of drugs, which include ergot alkaloids and caffeine. When it is combined with barbiturates and anticonvulsants, caffeine clearance is increased and its metabolism is accelerated.

Nicotine promotes the rapid withdrawal of the drug, and stimulators of the CNS - excessive excitability.

This drug reduces the effect of hypnotics, narcotic analgesics, and also increases the toxicity and absorption of cardiac glycosides and non-narcotic analgesics.

Joint intake of caffeine with beta-adrenoblockers often leads to mutual suppression of their therapeutic effects, and with adrenergic bronchodilators - to stimulation of the central nervous system and other additive toxic reactions.

It should also be noted that the active substance of this drug can reduce the clearance of theophylline and other xanthines.

The vasoconstrictor effect of this drug is enhanced by beta-blockers, alpha-adrenostimulators, nicotine and serotonin agonists.

The toxicity of ergotamine is increased by macrolides.

The cost of the drug and similar drugs

You can buy this product in the amount of 10 tablets for 100-150 rubles. If required, it can be replaced with such similar drugs as Cofergot, Ergofain, Nomigren, Ergoffin. However, before this, you should always consult a doctor.

Feedback from specialists and patients

Now you have an idea of how the medication "Kofetamin" works. Instructions for use of this agent have also been described above. Reviews about him are mostly positive. Those people who use this remedy say that it works effectively in case of severe migraine. This drug is more effective than other, more expensive drugs. Consumers report that they only need to take two tablets a day. This dosage immediately stops pain. Although sometimes unpleasant feelings remain even after taking the medicine. But in this case they are not very pronounced.

To the negative sides of this remedy include a large number of adverse reactions that are manifested against the background of its administration.