"Glutargin": instructions for use, reviews, analogues and prices

The drug "Glutargin" refers to hepatoprotective drugs, whose effect is aimed at normalization of metabolic processes in the liver cells by removing toxic substances from them and stabilizing the state of cell membranes. The use of this drug is associated with many features of the patient's body and its current state. We will talk about this and many other things in the article.

Composition and form of release

The active substance of the drug is arginine glutamate. In all pharmaceutical forms this substance is contained in different concentrations. Among the dosage forms of the preparation "Glutargin" the instruction for use mentions the following:

• Powder for self-preparation of a solution intended for oral administration, containing 1 g of arginine glutamate per serving;
• Tablets for oral administration with an amount of active ingredient 0.25, 0.75 and 1 g;
• Composition for the preparation of infusion solutions (concentrated) with an arginine glutamate content of 0.4 g per ml;
• A ready solution in ampoules with an active substance concentration of 0.04 mg per ml.

Powders for the preparation of the drink are packed in polymer bags of 2 or 10 pieces in a cardboard box, along with instructions for use. Tablets are placed in contour packs of 2 or 10 pieces, 1, 2, 3, 5 or 10 blisters in a cardboard box (also with the instructions in the kit). Concentrate and the finished solution are poured into glass ampoules. Those, in turn, are placed in plastic cuvettes of 5 pieces each. One cardboard box can contain 1 or 2 cuvettes, instruction on the use of the drug and scarifiers for opening ampoules.

Leave and storage conditions

The drug "Glutargin" instructions for use refers to OTC medicines. To purchase this medication, you do not need to take a special prescription from the treating doctor, but this does not mean that you can take it to all patients without exception.

Store the medicine in rooms that do not penetrate direct sunlight, at a temperature of no higher than 25 degrees. The shelf life of the drug is 2 years from the date of release. At the end of this time, the tablet, solution or powder "Glutargin" recommends that the disposal instruction be disposed of with household waste.

Properties

Pharmacological action of the drug is based on its ability to bind and remove ammonia from the body in a short time. The harmful substance is converted into a non-toxic form - glutamine, which is removed from the CNS naturally. The active component of the drug normalizes the state of the cell membranes, thereby activating the natural processes of protecting the body. Glutamate arginine also has antioxidant efficacy, which allows it to protect body cells from damage by free radicals.

The ability of arginine glutamate to positively influence the energy supply of liver cells makes it possible to use the drug even with alcohol intoxication. This property is based on stimulating the metabolism of ethanol by blocking the processes of inhibition of the corresponding enzymes. At the same time, arginine glutamate increases the amount of succinic acid synthesized in the body and excites the neurotransmitter centers of the central nervous system.

Indications for use

The drug "Glutargin" is recommended for use by patients suffering from the following diseases and disorders of the body:

1. Diseases of the liver, including hepatitis in acute or chronic form, cirrhosis, hepatic encephalopathy (alcoholic or other).
2. Leptospirosis, accompanied by damage to liver tissue.
3. Hyperammonemia, in which the patient is in a state of coma or precoma.
4. Poisoning by toxic substances, including poison pallid grebe, medicines, chemicals and alcohol.
5. An abstinence syndrome and / or a post-toxication condition caused by a prolonged intake of alcohol.

Take "Glutargin" (tablets) instructions for use and recommends as a preventive measure before drinking alcohol products. This helps to avoid intoxication of the body and quickly restore its normal functioning.

Contraindications

Despite the fact that the drug contains only one active ingredient, its administration is contraindicated in a variety of diseases or organ failure. So, the drug "Glutargin" instruction (doctors' reviews confirm this fully) does not recommend taking any phenylketonuria and hypersensitivity to the main and / or any auxiliary substance. Do not use any medicinal form of the drug with medicinal purpose for people with severe impairment of the functioning of the urinary system and kidneys in particular.

In the list of contraindications to the use of medicinal forms of the drug "Glutargin" instruction for use (doctors' reviews - direct confirmation of that) includes pregnancy and the period of breastfeeding, as well as the patient's age to 18 years.

With special care, this drug should be administered to patients with pronounced excitability and febrile status. Organic or physiological changes in the functions of the urinary system, which caused the inability of the kidneys to excrete nitrogen-containing metabolites, should also raise concerns about taking the medication. As a rule, if therapy is necessary with the use of this drug, the patient remains under round-the-clock supervision of medical staff.

How to take Glutargin

Let's pass to the main issue - the rules of taking the drug depending on its dosage form. The drug "Glutargin" (pills) the instruction advises to take three times a day for 750 mg. Based on the patient's condition, the attending physician can increase the dosage, which in any case should not exceed 2 g per reception. Tablets should be washed down with a sufficient amount of water (about 100 ml).

Powder, better known as "Glutargin 4", is recommended for use as a solution. To do this, dilute the contents of one packet in 75 ml of water immediately before taking. In acute alcohol intoxication, the solution is taken four times a day on the first day, the next 2-3 days - one serving twice a day. As a prophylactic, the drug "Glutargin" (powder) is drunk in a double dose (2 packs per 1/2 cup of water) an hour before the start of the meal.

The Glutargin solution (ampoules) recommends the use of the instruction for acute alcohol poisoning. The preparation prepared or prepared from the concentrate is administered intravenously twice a day by a drop method from the calculation of 2 g of the drug in one procedure. The rate of administration should not exceed 70 drops per minute. The course of treatment lasts no less than five, but not more than 10 days. At the end of therapy it is recommended to take powder or tablets "Glutargin" (no more than 1 g per day) within 20 days.

Adverse reactions and overdose

Among the adverse reactions in the treatment of the drug, patients and doctors in their reviews refer to such phenomena as nausea and discomfort in the stomach. As a rule, unpleasant symptoms pass independently in a short time and do not require the admission of special drugs.

If the rules recommended by the instruction are not followed, the drug "Glutargin" can cause an overdose. Symptoms of it are a short decrease in blood pressure, lack of sleep, chest pain, nausea and the urge to vomit. Also, according to reviews of specialists, the patient may be bothered by allergic reactions. Treatment for overdose is symptomatic, in rare cases, the administration of antihistamines and / or glucocorticosteroids is required.

Special instructions and compatibility with other drugs

All dosage forms of the drug "Glutargin" do not affect the ability to drive vehicles and complex mechanisms. The drug for vision and the speed of psychomotor reactions do not work.

Particular attention in the appointment of a maximum dosage is required by patients with impaired functioning of the endocrine system: diabetes mellitus, acromegaly. Doctors say that the drug in itself causes minor fluctuations in the level of hormones, but in combination with the drug "Aminophylline" can cause a surge in the content of endogenous insulin and growth hormone in the blood.

In addition, preparations containing glutamate arginine (including Glutargin Alkoklin), the instruction does not recommend taking together with drugs "Vinblastine" and "Dipiridamol", as they significantly reduce the effectiveness of each other.

Analogues of the drug "Glutargin", prices

To date, the pharmaceutical market can present several analogues of the drug "Glutargin". Some instructions Refers to the pharmacological group of hepatoprotectors of synthetic or natural origin: "Karsil", "Tiotriazolin", "Dipan" and "Gepa-Merz". A complete analog of the drug - "Glutargin Alkoklin" - contains the same active substance, i.e. arginine glutamate.

Compared with analogues, the drug "Glutargin" has a lower cost: about 75 rubles per 10 tablets with a dosage of 0.25 g and 100 rubles per packing of the same 10 tablets with glutamate arginine content of 1 g each. The powder costs a little more expensive - from 97 to 130 rubles per package containing 10 packages. The most expensive dosage form is a solution in ampoules. One package of a drug of 10 ampoules of 5 ml each costs at least 1000 rubles.

Opinion about the preparation

There are a lot of reviews about the drug "Glutargin". Patients in most cases talk about a good effect of the drug. In this case, they mention the appearance of some discomfort in the stomach (up to nausea). According to those who repeatedly resorted to the help of the drug "Glutargin", unpleasant symptoms quickly passed without receiving any special means. In addition, consumers noted the availability of the medicine, since it is inexpensive.