Drug "Ursosan": instructions for use

The drug "Ursosan" is released in the form of capsules, each containing 250 mg of ursodeoxycholic acid active substance. The drug is part of the clinical and pharmacological group of hepatoprotectors, which possess choleretic, gallstone-dissolving action.

Ursodeoxycholic acid is additionally characterized as a pharmaceutical agent with lipid-lowering, hypocholesterolemic and some immunomodulating effect.

The drug "Ursosan", the instruction for use indicates, has polar properties, which makes it possible to form non-toxic mixed micelles. Thus, it is possible to reduce the ability of gastric reflux to destroy cell membranes in diagnoses such as peptic gastritis, peptic esophagitis. Ursodeoxycholic acid can create double molecules that are part of the membranes of cells such as hepatocytes, cholangiocytes, GIT epitheliocytes, normalize their functions, and increase immunity to cytotoxic micelles.

The use of the drug "Ursosan" can reduce the level of toxic bile acids that damage hepatocytes, stimulate choleresis, influence the safe resolution of intrahepatic cholestasis, reduce the lithogenic index of bile. Therefore, the drug "Ursosan", the instruction for use indicates, is used to dissolve gallstones deposited from cholesterol, to prevent the deposition of new concrements in the bile ducts.

Immunomodulating effect is achieved due to inhibition of activity of some antigens, normalization of killer activity of lymphocytes. It has been established that ursodeoxycholic acid stops the development of fibrotic processes in those patients diagnosed with primary cirrhosis, alcoholic steatohepatitis, cystic fibrosis.

Drug "Ursosan", application

The drug is prescribed:

• With cholelithiasis, which proceeds without complications;
• When dissolution of gallstones formed from cholesterol in the gallbladder;
• For the prevention of recurrence of calculus formation after cholecystectomy;
• With chronic hepatitis in active form;
• With acute hepatitis;
• With toxic liver damage;
• With the primary cholangitis;
• With liver diseases associated with alcoholism;
• With steatohepatitis non-alcoholic origin;
• With primary cirrhosis of the biliary type;
• With cystic fibrosis of the liver ;
• With peptic gastritis and esophagitis;
• With biliary dyspeptic syndrome;
• For the prevention of liver diseases associated with the use of hormonal contraceptives or cytostatics.

The dosage of the drug is chosen by the doctor depending on the diagnosis and condition of the patient.

The drug "Ursosan", instructions for use, side effect

Disturbances in the digestive system are manifested by nausea, vomiting, diarrhea, constipation, transient elevation of hepatic transaminases; In the course of clinical trials, formation of calcified gallstones was observed.

Other disorders in the body can manifest as back pain, allergic reactions, exacerbation of chronic psoriasis, alopecia.

"Ursosan" medication, instructions for use, contraindications

Do not administer the drug in the following cases:

• With gallstones, containing a lot of calcium;
• With a bile-gastrointestinal fistula;
• With cholecystitis in acute form;
• With hepatic insufficiency;
• With acute cholangitis;
• With cirrhosis of the liver;
• With renal insufficiency;
• With obturation of bile ducts;
• With acute infectious disease of the gallbladder;
• With empyema of the gallbladder ;
• With increased sensitivity to the drug.

When prescribing the drug to dissolve gallstones, the doctor must take into account that the deposits must have a cholesteric origin, not exceeding 15-20 mm in size. In this case, the gallbladder should function, remain free more than 50%, so that the patency is maintained.