«Coldrex»: reviews. Coldrex Hotrem: instructions for use

Each of us at least once in my life encountered a cold. Increased temperature, stuffy nose, headache and other unpleasant symptoms of it sometimes get so boring that you want to get rid of them as quickly as possible.

They say that it is necessary to fight the cause, and not to heal the symptoms. However, the treatment of the virus usually takes at least a week, and with his eerie symptoms you want to straighten out now. What to do in this case? Buy antibiotics? What if there is absolutely no time to visit the doctor?

"Coldrex" (reviews about which are quite good) - a drug that helps the body to fight the symptoms of flu and cold, namely:

• Reduces elevated body temperature;
• Eliminates the headache, as well as pain in the joints and muscles;
• Eliminates nasal congestion;
• Removes the pain in the throat.

"Coldrex", the price of which varies from 150 rubles per tablet to 300 rubles for bags of powder, you can find in almost every drugstore in any city in Russia. The drug can be bought without a prescription.

It does not cause drowsiness and eliminates symptoms after the first intake.

A little about the manufacturer

"Coldrex" (reviews about it we will consider later) is the products of the world famous pharmaceutical company "GlaxoSmithKline." It was formed in the distant 2001, and today it accounts for almost 6% of the world pharmaceutical market.

Its headquarters are located in the UK, but the offices of GlaxoSmithKline are open in 114 countries around the world, with 24 laboratories and 78 factories. GSK products are distributed in more than 150 countries around the world.

How to choose the product that suits you?

There are several variants of the preparation "Coldrex". Their composition is unimportant, but still different. The drug is available in tablets or in powder for the preparation of solution. Below you will find a detailed description of each species.

Means of "Coldrex". Pills

This form of the drug is available in the form of two-layer capsular tablets, one layer of orange, the second - white. On one side of the tablets, the inscription "Koldreks" was ousted. The composition of one tablet is as follows:

• 500 mg of paracetamol;
• 30 mg of ascorbic acid;
• 25 mg of caffeine;
• 20 mg of terpinhydrate;
• 5 mg of phenylephrine hydrochloride.

Also in the composition of the tablet there are some auxiliary substances:

• 103.5 mg of corn starch;
• 30 mg of pregelatinized starch;
• 12.47 mg of talc;
• 6.24 mg of stearic acid ;
• 4 mg of povidone;
• 0.8 mg of potassium sorbate;
• 0.8 mg of sodium lauryl sulfate;
• 0.4 mg of dye E110 (sunset yellow sunset).

Based on the composition of the tablets, it can be concluded that the effect of one tablet is slightly weaker (less amount of the active component of paracetamol) than the preparation "Koldreks" (powder).

Below is an instruction on the use of "Coldrex" tablets.

This form is intended for oral administration. For adults and children over 12 years of age it is recommended to take two tablets no more than 4 times a day. In addition, between receptions should take about 4 hours. The total number of tablets taken per day should not exceed 8 pieces.

Children from 6 to 12 years are recommended to take one tablet no more than 4 times a day. The total amount per day is no more than 4.

Children under 6 years without a doctor's recommendation can not take this medication.

It is also not recommended to exceed the daily dosage and take "Coldrex" with some other drugs (see the section "Interaction of" Coldrex "with other drugs"). During treatment, refrain from using caffeine, as this can lead to unwanted side effects of the drug (see the section "Side Effects").

If after treatment the symptoms still remain, you should consult a therapist.

The drug "Koldreks (powder) MaxGrip"

"Coldrex MaxGrip" - a preparation in the form of a powder, which is used for the preparation of a solution. This powder is light yellow with the smell of lemon. It dissolves in hot water and forms a solution of a dull yellowish color without foam, also with the smell of lemon. Intended for oral administration.

"Coldrex" - bags (each of 5 grams) consist of:

• 1000 mg of paracetamol;
• 40 mg of ascorbic acid;
• 10 mg of phenylephrine hydrochloride ;
• 3725 mg sucrose;
• 680 mg of citric acid;
• 430 mg of sodium citrate;
• 200 mg of corn starch;
• 200 mg of lemon flavor;
• 79 mg of sodium cyclamate ;
• 54 mg of sodium saccharinate;
• 7 mg of dye E100 (curcumin);
• 2 mg of colloidal silicon dioxide.

As you have noticed, there is no caffeine in the Koldreks MaxGrip. However, the presence of sucrose in it suggests that if you are sick with diabetes mellitus, fructose intolerance or similar diseases, then you should refrain from using this medication.

So, we considered the composition of the preparation "Koldreks" (powder). Instructions for use are listed below.

To prepare the solution, you need to dissolve the contents of one sachet in half a cup of hot water. If necessary, then add cold water and sugar to taste.

The drug is intended only for adults.

The maximum daily dose of the drug is 4 sachets, with interruptions of 4 hours between each intake.

It is not recommended to continue treatment more than 5 days. If symptoms do not pass during this time, you should consult a doctor.

The drug "Coldrex (powder) HotRem"

The "Coldrex HotRem" product differs from the "MaxGrip" preparation only in that the amount of the main active component (paracetamol) in it is slightly less. In the rest it is the same preparation in the form of a powder, with the help of which a solution for oral administration is prepared.

Pay attention to what kinds of this drug from the family "Coldrex": lemon and honey, just lemon, and in some countries there are many other varieties, which, unfortunately, are not very common in Russia. We will take a closer look at HotRem. Lemon and HotRem. Lemon and Honey. "

Each packet of the drug "Coldrex HotRem. Lemon »consists of:

• 750 mg of paracetamol;
• 10 mg of phenylephrine hydrochloride;
• 60 mg of ascorbic acid;
• 600 mg of citric acid;
• 40 mg of sodium saccharinate;
• 500 mg of sodium citrate;
• 50 mg of lemon tetromide 100%;
• 83.33 mg of lemon flavor;
• 0.75 mg quinoline yellow dye (E104);
• 2904.42 mg sucrose.

We examined the composition of the preparation "Coldrex HotRem". Instructions for using this tool are described below.

The contents of the sachet must be dissolved in half a cup of hot water (but not boiling water). You can add sugar to taste or dilute the solution with cold water.

This tool is not recommended for children under 6 years. Children from 6 to 12 years can take the drug "Koldreks" no more than 3 times a day for one sachet. Adults - no more than 4 times one bag.

Means "Lemon and Honey. ColdreM HotRem ", the instruction to use which is the same as that of lemon, in fact, and the composition of it is not much different.

The composition of one sachet (5 g):

• 750 mg of paracetamol;
• 10 mg of phenylephrine hydrochloride;
• 60 mg of ascorbic acid;
• 600 mg of citric acid;
• 10 mg of sodium saccharinate;
• 500 mg of sodium citrate;
• 100 mg of lemon flavoring material PHS-163671;
• 75 mg of honey flavors PFW-050860;
• 125 mg of honey flavoring Felton F7624P;
• 50 mg dye caramel 626;
• 200 mg of corn starch;
• 50 mg aspartame;
• 2468.50 mg sucrose.

As you can see, the active substances in it are the same and in the same quantity, so that these species act in the organism in the same way. The difference is only in the amount of flavors and dyes. By the way, in the preparation "Koldreks. Lemon and honey "of this honey, or at least its extract, no. There are only honey flavors.

The drug "Coldrex (powder) Junior"

Designed for children from 6 to 12 years. It is also available in the form of a powder of light yellow color, with which you need to prepare a solution.

The composition of one packet of the preparation "Koldreks Junior":

• 300 mg of paracetamol;
• 5 mg of phenylephrine hydrochloride;
• 20 mg of ascorbic acid;
• 21.5 mg of sodium saccharinate;
• 31, 5 mg of sodium cyclamate;
• 340 mg of citric acid;
• 215 mg of sodium citrate;
• 100 mg of corn starch;
• 1862.5 mg sucrose;
• 100 mg of lemon flavor;
• 3.5 mg of curcumin E100;
• 1 mg of colloidal silicon dioxide.

As you noticed, other drugs in this series contain more paracetamol than the "Junior Coldrex" medication (powder). Instructions for using this tool are given below.

Dissolve the contents of the sachet in half a cup (125 ml) of hot water. If desired, dilute with cold water, add sugar.

It is recommended to use one sachet 4 times a day. Continue treatment for no more than 5 days.

Interaction of "Coldrex" with other drugs

For convenience, we will separately describe the interaction of each active component with other drugs.

Paracetamol

The main active ingredient, is able to enhance the effect of indirect anticoagulants (drugs that prevent the formation of prothrombin in the liver - drugs "Warfarin", "Dicumarin", "Sinkumar" and others), which significantly increases the risk of bleeding. This effect is observed only after repeated use.

With the simultaneous use of inducers of microsomal oxidation enzymes in the liver (such drugs as Diphenin, Carbamazepine, Rifampicin, Phenytoin, Zidovuin, barbiturates, tricyclic antidepressants) with paracetamol, the risk of hepatoxicity increases.

Paracetamol also reduces the effectiveness of the action of diuretic drugs and enhances the effects of ethanol, sedatives, MAO inhibitors.

Phenylephrine

Leads to Increased blood pressure when taken concomitantly with MAO inhibitors. Reduces the effectiveness of antihypertensive drugs, can increase the risk of hypertension, as well as cardiovascular system.

When taken together with halothane, the risk of ventricular arrhythmia increases.

Various antipsychotics, antidepressants, phenothiazine derivatives with simultaneous admission with the drug lead to a delay in urine, constipation, dry mouth.

Ascorbic acid

When interacting with sulfonamides or salicylates, it can slow down the excretion of acids by the kidneys. When taken with drugs that have an alkaline reaction, increases the rate of their elimination.

The drug should not be taken concurrently with other paracetamol-containing drugs, as well as with other non-narcotic analgesics, acetylsalicylic acid, sodium metamizole, ibuprofen, barbiturates, rifampin, antiepileptics, chloramphenicol, decongestants, appetite suppressants and other drugs to alleviate the symptoms of flu and colds .

Also, Coldrex can distort the results of some laboratory tests and it is worth informing your doctor that you are treating.

Important note!

Paracetamol should in no case be consumed with alcoholic beverages, as this leads to toxic damage to the liver!

Contraindications

All the variants of the preparation "Coldrex" (sachets of powder or tablets) have the same contraindications. So, you do not need to take Coldrex if:

• You are hypersensitive to any component of the drug;
• You have kidney or liver damage (even slightly pronounced);
• You are a person with excessive thyroid activity (hyperthyroidism, or thyrotoxicosis);
• You are sick with diabetes mellitus or have hereditary disorders associated with absorption of sugar (the drug contains sugar!);
• You have heart disease (acute myocardial infarction, tachyarrhythmia, stenosis of the aortic estuary);
• You are taking any tricyclic antidepressants, beta-blockers, MAO inhibitors, or stopped taking earlier 14 days ago;
• You have hypertension;
• You are taking other drugs containing paracetamol;
• You have prostate adenoma;
• You are not 12 years old;
• You have intolerance to fructose, a deficiency of sucrose (isomaltase), or you have glucose-galactose malabsorption.

The drug can be taken, while observing the measures of caution, if you:

• Genetic absence of glucose-6-phosphate dehydrogenase;
• Benign hyperbilirubinemia;
• Pheochromocytoma;
• Vasospastic diseases (Raynaud's syndrome);
• Any diseases of the cardiovascular system.

With the above ailments, you will need to consult a doctor before taking the drug "Koldreks."

It is also advisable to consult a doctor if you are pregnant or breastfeed.

Side effects

For convenience, side effects are also classified by the active substances that cause them, and by organ systems.

Paracetamol

Very rarely causes any side effects.

• Allergic reactions: can cause anaphylactic shock, skin rash, angioedema, hives, Stevens-Johnson syndrome.
• Respiratory system: very rarely occurs bronchospasm in patients who have increased sensitivity to acetylsalicylic acid and other NSAIDs.
• Liver and biliary tract: rarely enough violations of the liver.
• Organs of hematopoiesis: may cause leukopenia, thrombocytopenia or agranulocytosis (very rarely).

Phenylephrine

Often has side effects.

• Nervous system: often after taking the drug may appear headache, insomnia, dizziness, increased excitability.
• Cardiovascular system: tachycardia can rarely develop. More frequent side effects are increased blood pressure.
• Digestive system: often phenylephrine causes nausea, vomiting.
• Sense organs: you can notice the dilated pupils (mydriasis).
• Allergic reactions: urticaria, skin rash allergic dermatitis - a rare side effect of phenylfrin.

Ascorbic acid

May cause Skin rash or flushing, irritation of the mucosa of the gastrointestinal tract.

Pay attention, that at occurrence of any by-effects it is necessary to address urgently to the doctor and at all to not treat them independently.

If you notice any other side effects not described above, you should tell the doctor about it.

Overdose

If you know for sure that you used a larger amount of the drug than you need, but there are no symptoms of an overdose, you still need to seek help from a doctor, since there is a risk of delayed liver damage.

So, we will describe in detail the symptoms of overdose of each active substance from the composition of the preparation and their treatment.

Paracetamol

Symptoms of overdose:

• During the first 24 hours, paleness of the skin may appear, a feeling of nausea, vomiting, appetite may decrease, a pain in the abdomen may appear;
• After 12-48 hours, liver function impairment can manifest itself.

When more than 10 g of paracetamol is taken, an increased activity of "liver" transaminases appears. When poisoning with paracetamol develops severe hepatic insufficiency, which leads to hepatic encephalopathy and even coma or death.

Treatment of overdose:

• During the first hour it is desirable to take several tablets of activated charcoal and immediately consult a doctor. Further independently it is not necessary to be treated.

Phenylephrine

Symptoms of an overdose are similar to its side effects:

• First of all there is dizziness, headache, insomnia, increased blood pressure, nausea, vomiting;
• In severe cases, there may be hallucinations, convulsions, arrhythmia.

Self-treatment of an overdose of phenylephrine can not.

Ascorbic acid

In an amount of more than 3000 mg causes osmotic diarrhea, gastrointestinal disturbances - discomfort in the stomach, nausea, vomiting. If you find these symptoms, you need to see a doctor immediately.

"Coldrex": reviews

At the beginning of the article it was said that the reviews about the Koldrex facility are quite good.

This is true, more than half of people who take this drug, spoke positively about it.

But there are still negative sides:

• A huge number of side effects;
• high price;
• Too much paracetamol in the composition.

This has already been discussed in the article, but it should be emphasized once again that in any preparation there are minuses.

Plus he has much more:

• He perfectly copes with the symptoms of flu and colds;
• Has a pleasant taste;
• Can be taken by both children and adults;
• Tablets greatly simplify the treatment process (some dislike the taste of similar solutions);
• The drug has several flavors;
• Convenient packing.

Some analogues of the preparation "Koldreks"

Unfortunately, the cost of this tool is high enough, so some people are looking for quality analogs.

And indeed, there are some remedies that do not differ in composition and are much cheaper than the drug "Coldrex". Analogs are these:

• Powder "Teraflu." It is approximately in the same price category with the preparation "Koldreks". The composition is the same.
• The drug "Maxikold". Absolutely similar composition, and its cost does not exceed 150 rubles, which is an order of magnitude lower than the cost of Koldrex or TeraFlu.
• Means of "Flucodex-C". Identical composition, acceptable price - about 80 rubles.
• Powder "Prostudox". Another tool, similar in composition, but with a much lower price. The drug can be bought for only 70 rubles.
• Means Influnorm. The price is about 100 rubles, and the composition is identical to the composition of the drug "Coldrex".

For more information, contact any pharmacy in your city. It is not necessary to buy exactly the drug "Coldrex". Analogues of it are also very effective.

Perhaps the pharmacist at the pharmacy will tell you some remedy that was not mentioned above.

So, in this article we reviewed the drug "Coldrex": reviews, composition, method of application, side effects, overdose and other its features.

Remember that any medicine is not as safe as it seems. And the preparation "Koldreks" (powder and tablets), the instruction for use of which we considered today, is also not safe.