Decapeptil: instructions for use, composition, indications and contraindications

How should I apply Decapeptil medication? Annotation on the use of this drug will be presented below. Also, you will learn about the indications for the use of this drug, its analogs, side effects and so on.

Decapeptil: description of the preparation, its composition and form

This drug is sold as a clear and colorless injection solution, which has no odor, as well as mechanical impurities.

The main component of this medication is triptorelin acetate. In addition, it includes ingredients such as glacial acetic acid, sodium chloride and water for injection.

You can buy Decapeptil solution, the photo of which is presented in this article, in syringe-ampoules complete with injection needles, which are packaged in contour boxes and carton boxes, respectively.

The action of the drug (pharmacological)

What is Decapeptil Solution? Instruction for use reports that it is a synthetic analogue of GnRH, or the so-called gonadotropin-releasing hormone.

After the administration of this drug, its active substance causes an increase in the level of LH and FSH in the blood, which ultimately leads to a short-term increase in the concentration of sex hormones. Prolonged stimulation of the pituitary (for example, with regular use of the drug) contributes to the blockade of gonadotropic work. The result of this effect is the reduction in the number of hormones (genital) to menopausal or postastratsionnogo. These effects are reversible.

Studies on laboratory animals did not reveal a mutagenic or teratogenic effect of the drug in question.

Pharmacokinetics of the injectable preparation

What pharmacokinetic properties are characteristic for the Decapeptil solution? Instructions for use asserts that in the first 50-90 minutes after the administration of the drug, tryptorelin in the blood reaches its maximum. Further, the concentration of this substance is markedly reduced (throughout the day).

The half-life of the main component is 18.7 minutes. About 4% of tryptorelin is excreted with urine unchanged.

It should be especially noted that pharmacokinetic tests of this medication have been performed in people with a confirmed diagnosis of uterine myoma or endometriosis, as well as in healthy male volunteers and patients with prostate carcinoma.

Indications for injection of an injection solution

What is the purpose of the drug "Decapeptil"? Indications for the use of this solution for women are as follows:

• Uterine myoma;
• Infertility therapy using reproductive technologies (eg, embryo transfer, IVF);
• Endometriosis.

As for men, this remedy is recommended for symptomatic treatment of hormone-dependent progressive prostate carcinoma.

Prohibitions for the introduction of medicinal products for men and women

In which cases can not you enter Decapeptil solution? Instructions for use indicate that for women this drug is contraindicated:

• When breast feeding;
• Pregnancy;
• Clinical manifestations or the risk of osteoporosis.

It should also be noted that with caution this drug is used in the implementation of the IVF program in patients with polycystic ovaries (that is, if the number of follicles that are determined by ultrasound is more than 10).

For representatives of the stronger sex, the medication in question is contraindicated:

• With surgical castration (preceding);
• Prostate carcinoma (hormone independent).

A general ban on the prescription of this drug is the patient's hypersensitivity to triptorelin or to other components of the drug.

Decapeptil solution: instructions for use

This medication is intended for subcutaneous administration. In endometriosis, prostate cancer and uterine myoma, the drug is administered in an amount of 0.5 mg / ml once a day for a week. On the 8th day, they switch to a maintenance dosage of 0.1 mg / ml once a day.

In the process of treatment, this means necessarily conduct ultrasound and monitor the size of fibroids and endometriosis foci.

When the IVF program is administered, the medication is administered according to protocols (may be ultrashort or short). In order to prevent post-injection reactions, the injection site is changed every time.

When should I use Decapeptil Depot solution? The instruction for use says that this remedy is indicated with a long course of therapy. It is also administered subcutaneously in the abdomen or intramuscularly once in 30 days.

The prepared solution is used immediately. With endometriosis and uterine myoma, the therapy is started in the first days of the cycle. Such treatment should last about 3-6 months. In prostate cancer prostate therapy is also carried out for a long time.

When carrying out IVF, the drug "Decapeptil Depot" is administered once on certain days of the cycle.

Side effects

What are the undesirable reactions that cause Decapeptil Solution? The instruction, the reviews report that the side effects manifested in the background of the use of the drug in question are due to a decrease in the number of sex hormones in the blood, which can ultimately lead to the development of symptoms such as depression, mood lability, frequent headaches, weakening of libido, sleep disorders , Hot flashes, weight gain and increased sweating. In addition, in some patients the following changes were observed:

• Obstruction of the urinary tract, paresthesia, pain during sexual intercourse;
• Visual impairment, back pain, muscle weakness;
• In women - uterine bleeding and dryness of the vagina;
• In men - gynecomastia, a decrease in potency and a decrease in the size of the testicles;
• Nausea, redness of the skin, decreased appetite, itching;
• Fever, hypercholesterolemia, bone pain caused by metastases;
• Myalgia, spinal cord compression, anaphylaxis;
• Arthralgia, pain at the site of medication, demineralization of bones (with prolonged use);
• Enlargement of lymph nodes, thrombophlebitis, edema of the legs;
• Loss of hair on the legs, chest and arms, reducing the growth of the beard.

It should be specially noted that all of these side effects disappear immediately after the end of the course of therapy.

Drug interactions, cases of overdose

Cases of overdose with the drug in question was not observed. With the development of any negative signs against the background of exceeding the dose of the drug should be symptomatic treatment.

There was no drug interaction between Decapeptil and other drugs.

Special information for patients

The course of treatment with the drug "Decapeptil" should be carried out under strict control of the level of sex hormones in the blood.

Women should conduct a study to exclude a possible pregnancy. During the use of the drug, it is unacceptable to use hormonal contraceptives, as well as preparations containing estrogens.

The patient should be warned that during the course of treatment with the drug in question, menstruation will be absent.

The use of this tool in men can lead to a temporary deterioration in their condition. If you have negative symptoms, you should immediately contact a doctor.

Similar drugs

What can I replace the drug solution "Decapeptil"? Analogues to this drug are difficult to pick up, so this procedure should only be done by an experienced doctor.

According to some experts, the medicine in question can be replaced by the following means: Zoladex, Buserelin-Depot, Diferelin, Triptorelin.

Feedback on injection solution

At present, for the therapy of endometriosis and other diseases of the reproductive system, gonadotropin-releasing hormone agonists are most effective and effective. They include such drugs as "Decapeptil", "Diferelin", "Zoladex" and others. However, it should be noted that the high cost of such funds does not allow them to be widely used in medical practice. In this regard, there is not much feedback on their application.

According to reports of specialists, the drug "Decapeptil" is especially often prescribed for the treatment of uterine fibroids (duration 5-6 months). This use of the drug led to a decrease in the volume of the uterus and the size of the nodes. Further operative intervention was carried out. Thus, treatment with "Decapeptil" was prescribed as preoperative preparation.

Many patients claim that after the administration of the solution they often had pain at the injection site, itching and redness. Also there were headaches, hot flashes, insomnia and fatigue.

Positive reports about this drug are often left by women who used Decapeptil according to the IVF protocol. Due to this preparation in most cases the procedure of embryo introduction into the uterus was successful. Of the side effects of the fairer sex noted hot flashes and sweating.