"Ukrliv" preparation: instructions for use, description, composition and reviews

Quite often, modern doctors for certain diseases to their patients prescribe the drug "Ukrliv." The instruction for this tool includes a sufficiently large amount of useful data and for many is the most important source of information. But at the same time, not all correctly understand the written there, and what is provided in it is not a complete list of information about this drug.

Act

Ursodeoxycholic acid in the predominant majority of cases is always in a small amount contained in the bile of a person. If taken orally, it begins to significantly reduce the overall degree of bile enrichment with cholesterol by slowing its absorption inside the small intestine, as well as reducing the secretion of this element in the bile. It is quite obvious that due to dispersion of this organic compound and the formation of liquid crystals, cholelithiasis cholesterol begins to partially dissolve, which positively affects the general state of the human body.

In accordance with current scientific evidence, it is believed that ursodeoxycholic acid in the case of various liver diseases or cholestatic diseases allows to achieve the effect due to the relative replacement of lipophilic toxic bile acids similar to detergents to hydrophilic nontoxic cytoprotective ursodeoxycholic acid, and subsequently a noticeable improvement in the secretory function Hepatocytes and various immunoregulatory processes.

When is it used?

To the drug "Ukrliv" the instruction indicates that most often doctors prescribe it if the patient has cholesteric gallstones, whose diameter is no more than 15 mm. In most cases, this remedy is prescribed to patients with a functioning gall bladder, which works regardless of the presence of one or several gallstones in it. In particular, to the preparation "Ukrliv" the instruction says that this product allows to completely dissolve X-ray cholesteric gallstones.

Among other things, the use of this drug is often prescribed if necessary symptomatic treatment of primary biliary cirrhosis in the absence of decompensated cirrhosis of the liver.

Pharmacokinetics

After taking the drug, ursodeoxycholic acid begins to be absorbed quickly enough in the small intestine, as well as in the upper region of the ileum through passive transfer, and in the terminal ileal compartment by active transfer. In the majority of cases, the degree of absorption is from 60% to 80%, as indicated in the instruction "Ukrliv". After complete absorption, bile acid gets under the influence of almost complete hepatic conjugation with amino acids taurine and glycine, as a result of which it is completely eliminated together with bile. It is worth noting the fact that the clearance of the primary passage through the liver reaches a rate of 60%.

Under the influence of various intestinal bacteria, partial degradation occurs to lithocholic and 7-ketolithocholic acid. In this case, lithocholic acid acts as a hepatotoxic substance and causes all possible damages of the hepatic parenchyma in certain species of animals. A person only absorbs a certain part of the substance, which is completely sulphated in the liver and detoxified even before it is excreted with feces and bile.

How is this drug used in pregnancy?

Women of reproductive age can use this drug only if they use sufficiently reliable contraceptives. Before the beginning of treatment it is extremely important to completely eliminate the possibility of pregnancy. In order to ensure maximum safety, treatment should in no case be carried out during the first trimester of pregnancy. To the preparation "Ukrliv" (tablets) the instruction indicates that an exception is provided in the cases when the doctor believes that the benefits of using this tool exceed possible risks.

There is no accurate clinical data on the use of ursodeoxycholic acid by women during breastfeeding, and therefore the use of this drug in this category of patients is not recommended.

Contraindications

To the preparation "Ukrliv" (tablets), the instruction notes several main contraindications to the use of this drug:

• Presence of acute inflammation of the bile duct or gall bladder;
• Presence of excessive sensitivity to certain substances in the drug;
• Clogging of the bile duct (this includes both clogging of the common duct and individual blockages of the bladder);
• Cirrhosis of the liver, which is in decompensation stage.

Among other things, it should be noted that this remedy should not be given to a patient with a gallbladder who is not visualized by X-ray methods, as well as to patients with impaired gallbladder contractility, calcified stones or those with frequent biliary colic , As evidenced by the instruction "Ukrliv" (suspension) instruction. The doctors' comments also confirm this fact, since the specialists do not prescribe this remedy in the above situations.

Side effects

In the process of taking this medication, the following side effects may occur:

• All kinds of disorders in the work of the gastrointestinal tract;
• In extremely rare cases in the treatment of primary biliary cirrhosis in patients there was a fairly strong abdominal pain in the right hypochondrium;
• In clinical trials it was determined that a certain group of patients had a loose stool or diarrhea during treatment with ursodeoxycholic acid;
• All kinds of disorders in the gallbladder and liver;
• Again, in extremely rare cases, calcification of gallstones occurred during treatment with this drug;
• In the process of therapy of the advanced stages of biliary primary cirrhosis in extremely rare situations, patients had decompensated liver cirrhosis, which partly regressed after the treatment was discontinued.

Among other things, doctors often point out in their reviews that side effects from taking this medication can be expressed by all sorts of hypersensitivity reactions or by rashes. Prone to allergies, people appoint it with caution.

How is it used?

There are no age restrictions with regard to taking this medication, as indicated in the instruction "Ukrliv" (tablets). The price of this drug, respectively, is the same regardless of which particular group of patients requires treatment.

For patients who have a body weight of less than 47 kg or who have difficulty in swallowing tablets, it is possible to use this drug in the form of a suspension, which is often noted by doctors. Depending on the specific indications of the attending physician, it is possible to use this drug in the following doses.

Dissolution of biliary cholesterol stones

• Weight: from 47 to 60 kg. Two tablets per day.
• Weight: from 61 to 80 kg. Three tablets a day.
• Weight: from 81 to 100 kg. Four tablets a day.
• Weight: more than 100 kg. Five pills a day.

Tablets should be used once a day, they should be swallowed whole and washed down with a small amount of liquid. To the preparation "Ukrliv" (tablets) the instruction for use says that it is best to use this remedy in the evening before bedtime, and the reception should be regular to achieve the desired effect.

Features

The time, which is required for the complete dissolution of gallstones, in the majority of cases is from 6 to 24 months. In the event that a decrease in the total size of gallstones is not observed after 12 months of active intake of this drug, continued therapy is not recommended.

To the drug "Ukrliv" (syrup) the instruction says that the success of treatment should be checked every 6 months by means of X-ray or ultrasound. Further research should be done on whether the patient does not calcify stones during treatment. If this happens, then the treatment procedure should be completely discontinued.

Symptomatic treatment of PBC

In the case of the patient's primary biliary cirrhosis, the mass of the patient directly affects the amount in which the drug "Ukrliv" should be used. The instruction says that depending on the mass, the daily dose can vary from 3 to 7 tablets.

During the first three months of therapy, tablets should be used throughout the day, with the daily dose to be divided into several doses. In the event that the liver values during this period have been improved, it will be possible to take a daily dose only once in the evening.

Tablets should be swallowed whole, they need to be washed down with liquid, and in this case it is also important to observe regularity. It is worth noting the fact that the instruction for use with the preparation "Ukrliv" (suspension) indicates that its use in case of the patient's primary biliary cirrhosis is provided for a long period, if this is required during the treatment.

Features

It should be noted that in patients with this diagnosis, in the first instance, in rare cases, clinical symptoms may worsen, and, in particular, some people experience an increase in itching. As the "Ukrliv" preparation testifies, the instruction, suspension or tablets in this case should be used later, but the daily dose should be reduced, and then gradually increase it to the required value over time. Thus, every week you need to increase the daily dose until the necessary dosage regimen is achieved.

Overdose

The extremely low risk of overdose provoking any serious side effects. In particular, there is a possibility of diarrhea, therefore it is highly recommended to periodically monitor the main indicators of liver function. In case of diarrhea it will be necessary to reduce the dosage, and if this does not help, completely stop using this medication, as indicated in the instruction manual for the drug "Ukrliv". The price of this product (from 460 rubles., Depending on the type of drug) allows almost everyone to use it in the right dosage.

No specific countermeasures are required in this case, and any consequences of diarrhea should be treated exclusively symptomatically, with careful compliance with the balance of electrolytes and fluids. This is important enough to achieve the maximum effect with the maximum degree of safety.