Tranexan. Instructions

Tranexan has a local and systemic hemostatic effect in conditions accompanied by increased amounts of fibrinolysin (platelet pathology, menorrhagia). The medication is able to suppress the formation of kinins and other active peptides involved in inflammatory and allergic processes. Thus, Tranexan has antitumor, anti-infective, anti-allergic and anti-inflammatory properties.

Excretion is carried out by the kidneys. If their function is impaired, cumulation (accumulation) of tranexamic acid can be noted . The drug penetrates through the blood-brain and placental barrier, evenly distributed in the tissues. Concentration lasts for seventeen hours. The maximum level of the drug in the plasma is noted after three hours after oral administration.

Tranexan. Description of indications

As a haemostatic agent for bleeding or the likelihood of their development as a result of increased fibrinolysin during operations, during the postoperative period, with manual separation of the afterbirth, postpartum hemorrhage, chorion detachment, malignant tumors of the prostate and pancreas, liver diseases, leukemia, bleeding during gestation.

With bleeding or the likelihood of their development against the background of local strengthening of fibrinolysin in uterine, nasal bleeding, as well as in the gastrointestinal tract. These states include hematuria, tooth extraction in patients with hemorrhagic diathesis.

The drug "Tranexan" instruction allows to use as an antiallergic agent for allergic dermatitis, urticaria, eczema, skin rash provoked by toxins and drugs.

The medication is prescribed for stomatitis, laryngitis, pharyngitis, tonsillitis as an anti-inflammatory therapy.

The drug is also used for angioedema edema of a hereditary nature.

Tranexan. Instructions for use

When strengthening fibrinolysin local character, from 1 to 1.5 g, three or four doses per day are recommended. With repeated bleeding from the nose - during the week for three doses of 1 g. After extraction (extraction) of the tooth for six to eight days for three or four admission of 25 mg / kg of weight. With profuse bleeding (uterine) - for twelve to fourteen days, three doses of 1.5 grams each. Therapy with an angioedema edema of a hereditary nature for 2-3 doses of 1-1.5 g continuously or under the supervision of a specialist.

Tranexan. Instructions for intravenous administration

The solution for injections is applied drip, jet.

When the local fibrinolysin is increased, 2-3 injections of 250-500 mg are administered, with a general increase every six to eight hours with a single dose of 15 mg / kg at a rate of 1ml / minute.

In cases of bladder surgery and prostatectomy, 1 g is injected during the intervention, followed by a gram every eight hours for three days. After this, they switch to taking the tablet form of the drug.

Patients with a clotting disorder before the extraction of the tooth are administered 10 mg / kg. After the extraction, tablets are prescribed.

In the presence of violations in the functions of the kidneys, it is necessary to recalculate the dosage in accordance with the level of creatinine.

Tranexan. Instructions. Side effects

Diarrhea, nausea, anorexia, vomiting, heartburn are noted on the part of the gastrointestinal tract. Dizziness, drowsiness, visual impairment, color perception, weakness are manifested by the central nervous system. There are pains in the chest, tachycardia, development of thromboembolism, thrombosis and other reactions of the cardiovascular system. With rapid administration, hypotension is likely to occur. The use of the drug also causes urticaria, skin rash, itching.

Tranexan. Instructions. Contraindications

The drug is not prescribed for hypersensitivity to components, with subarachnoid hemorrhage.