The drug "Tsedeks" for children (suspension): reviews. Instructions for use, contraindications

Babies are more likely to suffer respiratory diseases (both upper and lower), ENT organs. Pediatricians in this case prescribe antibiotic "Tsedeks" (for children a suspension). Reviews of mothers confirm that this medicine helps to recover with minimal consequences (while taking medications to restore intestinal microflora and, if necessary, antiallergic medicines).

Among the advantages of the parents mention a one-time intake of the drug (both in suspension and capsules), an effective fight against protracted bronchitis, sore throat, sinusitis, otitis, chronic rhinitis. But among the main disadvantages are the high cost of the drug. We will study in more detail the composition, instruction, side effects of this medication.

general characteristics

The drug belongs to the pharmacological group to the third generation cephalosporins. This means that the negative effects on health compared with the antibiotics of the first or second generation will be less for the medication "Tsedeks." The drug is also called "Ceftibuten", which is associated with the same name of the active substance in its composition. This antibiotic is produced by Italy, Switzerland, the USA (in Russia for the production of this product is responsible for Schering-Plow LLC).

The drug "Tsedeks" approved by the Russian Ministry of Health, is released on prescription. For children from 10 years old, the doctor prescribes this antibiotic in capsules, and for babies with half a year to ten years - in powder. Capsules are available in a blister pack of five or in separate bags. A measuring cup and a measuring spoon are attached to the packing of the suspension. Capsules and powder of medicament light yellow or white (rather milk) color.

Please note that the figures in the name of the medicine imply a dosage. That is, if "Tsedeks 400" is written, then this preparation is available in capsules, each of which contains four hundred grams of ceftibutene (more than this dose for a day can not be taken by children or adults). To prepare the suspension, the powder is released in 30 ml bottles (the dosage of the main substance is 36 milligrams per milliliter).

You can store antibiotic at a temperature of two to 25 degrees above zero. Unpackaged drug can last two years. However, the diluted suspension should be stored in the refrigerator at a temperature of 2-8 degrees for only two weeks.

The drug "Tsedeks": instruction, price

The antibiotic powder can be from light yellow to dark in dry form. In a dilute state, it acquires a milky tone and a cherry smell. The preparation contains ceftibutene dihydrate (36 milligrams per milliliter of diluted suspension and 144 milligrams per gram of dry powder), sucrose, xanthan gum (gum), titanium dioxide and silicon, simethicone, sodium benzoate, polysorbate 80, flavor additive (cherry). Diluted medicine should be stored only in the refrigerator. For more than ten days, do not use the Zedex suspension. The price of powder is on average 475 rubles.

Capsules have a slightly different composition. There is included ceftibutene (400 milligrams per capsule), magnesium stearate, microcrystalline cellulose, sodium starch glycollate. The sheath itself consists of gelatin, titanium dioxide and sodium lauryl sulfate.

The preparation in capsules is powder of white, milky or light yellow color, the shell has the name of the preparation (the composition of pharmaceutical ink includes a special glaze, simethicone, lecithin, black iron oxide (E 172), ethylene glycol monoethylate). Medication "Tzedex" (the price in capsules will be higher), like other tablets, is stored on the door of the refrigerator or in a cabinet where the temperature does not exceed 25 degrees above zero.

Action medication

This drug is called antimicrobial and antibacterial. It destroys the membrane of all bacteria that are resistant to other drugs belonging to the group of cephalosporins. This drug is resistant to the effects of most penicillinases and cephalosporinases. But the antibiotic is useless in controlling strains resistant to beta-lactam antibiotics (for example, penicillin-resistant streptococci).

Medication "Tzedex 400" and suspension destroy bacteria such as streptococcus, pneumococcus, moraxell catarrils, indolpositive protheus, hemophilic and intestinal sticks, klebsiella, providencia, salmonella. This is due to the inhibition of transpeptidase and the disruption of biological synthesis of the mucopeptide of the cell wall. Anaerobic microorganisms, staphylococci, group B Streptococcus, enterococci do not apply to this antibiotic.

Quickly absorbed from the intestinal tract, however, eating slows the rate of this process with the use of suspension (the drug in capsules is not covered). The peak of antibiotic accumulation in plasma is achieved two hours after its administration. The active substance of the antibiotic penetrates into the tissues and liquids in a short time (46-81% of the concentration of the drug in the plasma). The drug is excreted from the body in an unchanged state with urine.

Indications for use

The drug "Tzedex" (suspension, capsules) is used for the following diseases:

• Pharyngitis;
• Scarlet fever;
• Tonsillitis;
• Pneumonia;
• Chronic and acute bronchitis;
• Average otitis media;
• Sinusitis;
• Urethritis;
• Cystitis;
• Enteritis;
• Gastroenteritis caused by Escherichia coli, shigella, salmonella.

The medication is prescribed by the doctor and in the treatment of other infections that are destroyed by the action of ceftibutene. According to the instructions, children with half a year and adults can be prescribed treatment with the drug "Tsedeks." The use of this antibiotic is possible with side effects in individuals with renal insufficiency, gastrointestinal diseases, chronic colitis, penicillin allergy.

The effect of this drug on the fetus in prenatal development in the treatment of pregnant women has not been studied. There have also been no studies to determine the proportion of ceftibutene in breast milk, so breastfeeding mothers are also not recommended to take this antibiotic. But, judging by the reviews of women, many took this drug during pregnancy, during lactation in the treatment of protracted sinusitis and did not notice any negative consequences for the health of children. However, self-treatment in this case is unacceptable!

Contraindications

Infants up to six months, regardless of the severity of the disease of the ENT organs, upper or lower respiratory tract, categorically prohibited taking medication "Tsedeks" (for children a suspension). Experts' comments explain that this drug in infancy has a negative impact on the unformed central nervous system, causes a predisposition to allergies, digestive and circulatory system problems.

Also, you should not take an antibiotic to children who are sensitive to any component of the drug or have congenital pathologies of carbohydrate metabolism. If children have fructose intolerance, isomaltosis insufficiency, sucrose, there are problems with absorption of galactose or glucose, then the drug "Cedex" (suspension) is contraindicated in these cases.

Please note that children under 10 years of age are categorically prohibited from taking antibiotics in capsules. And from the adolescent period, the suspension does not contribute to recovery due to an insufficient amount of ceftibutene. Children weighing over forty-five kilograms are recommended a daily antibiotic norm, as for an adult, namely one capsule (four hundred milligrams). Therefore, follow strictly medical advice on the use of the drug.

Side effects

Any antibiotic has negative consequences for the body, including the "Tzedex" remedy. The instruction to the drug says that if the antibiotic is overdosed, the child may have a headache, nausea, diarrhea (diarrhea). These symptoms are common and appear when taking any other antibiotics.

Proceeding from the data of pharmacological observations, patients rarely experience such side effects as vomiting, abdominal pain, gastritis, dyspepsia, drowsiness, rash, nasal congestion, taste change, hemoglobin decrease in blood, thrombocytosis, eosinophilia, leukopenia, increased activity in Serum AST, ALT and LDH, convulsions.

In young children, other signs of an overdose may appear: agitation, insomnia, dehydration, chills, rigidity of the muscles, melena, fever, toxic skin necrosis, hyperkinesia, aphasia, hematuria, jaundice. These are rare negative phenomena that can occur after the appointment of the drug "Tsedeks" to children. Instructions for the use of any other antibiotic belonging to the cephalosporin group also describe a number of similar side effects.

• Immune disorders are characterized by the appearance of allergic reactions, bronchospasm, rash, dyspnea, anaphylaxis, toxic epidermal necrolysis, urticaria, pruritus, erythema multiforme, Stevens-Johnson syndrome, sensitivity to light, angioneurotic edema.
• At laboratory research parameters of a prothrombin time and INR change.
• On the part of the gastrointestinal tract, colitis and diarrhea are possible with the admission of the drug "Tsedeks" (the dosage in this case does not matter, since this is a general consequence of taking antibiotics of any pharmacological group).
• From the urinary and hematopoietic systems, renal dysfunction, anemia (aplastic, hemolytic), toxic nephropathy, internal bleeding, Coombs' positive reaction, hyperbilirubinemia, agranulocytosis, glucosuria, neutropenia, pancytopenia can be observed.

Despite the long list of side effects, no accidental overdose of intoxication symptoms was revealed. In addition, a detailed list of side effects indicates the degree of study of this drug in the field of medicine. The absence of undesirable effects in a medicinal product may indicate a lack of study of the effects of its components on the human body.

The drug "Tsedeks" (suspension): instruction

For children under 10 years of age, powder is prescribed for the preparation of the suspension. To do this, in a measuring cup (attached to the package) pour twenty five milliliters of boiled water at room temperature and poured into a vial of powder. Shake until the antibiotic is completely dissolved. Add another five milliliters of water and shake well.

Give the medicine as directed by a doctor using a measuring spoon or syringe. Note that the measuring spoon is two-sided: a round and oval measure. On each side there are two divisions with different values. Look at the division and pour the indicated amount of suspension. That is, if 90 ml is written on one side and 135 ml on the other, then turn the spoon with the desired division and measure the necessary amount of antibiotic.

Despite the fact that the bottle is designed for thirty milliliters of suspension, the doctor can change the amount of water and powder, based on the nature of the disease, the age and weight of the child. Then the drug "Tsedeks" (suspension for children under 10 years and capsules for older children) is given on the recommendation of the doctor.

If you are confused by a large number of side effects of the drug, then ask to replace the medicine with a more sparing. If you do not trust the competence of your attending physician, you will consult about treatment with other specialists.

Based on the severity of the disease, the drug is given one to three times a day for five days. For example, with acute bacterial enteritis, the drug is given twice a day, with pharyngitis or purulent otitis given once with the drug "Tsedeks." Instructions for dosage should be agreed with the attending physician.

In any case, the antibiotic of any pharmacological group is prescribed for five to ten days (no more than three times a day before meals or after) with parallel intake of prebiotics and live microorganisms that improve the intestinal microflora and antiallergic drugs (since many children have an allergic rash on medicine).

Be sure to adhere to medical recommendations when taking medication "Tsedeks" (for children suspension), reviews of some moms indicate their incompetence. Many of them determine the dosage "by eye", dilute the prepared suspension with warm water to obtain the optimum temperature.

Because of this, either an overdose occurs or the effectiveness of the drug on the body is reduced due to an insufficient amount of active substance. Remember, if you do not cure the infection, then it will adapt to the action of the antibiotic, then next time you need to apply a stronger medicine (and frequent antibiotic treatment by doctors is not welcome).

Application of the drug in adolescence

Standard treatment is prescribed for a period of five to ten days. Children under 10 and weighing less than 45 kilograms are given a suspension at a rate of nine milligrams per kilogram. Teenagers, whose weight is more than forty-five kilograms, is prescribed capsules with the drug "Tsedeks". Instructions for use emphasize the dependence on the severity of the disease. For example, in the treatment of chronic bronchitis, bacterial sinusitis or urinary tract infections, it is sufficient to take one capsule (400 mg) per day, and with pneumonia it is allowed to take two capsules with a dosage of 200 mg (ie, the dose is divided into 2 divided doses).

The intake of the drug of this form of release from food intake does not depend. It is also prescribed with the simultaneous administration of drugs aimed at restoring intestinal microflora. Some schoolchildren swallow tablets and capsules cause vomiting, so many mothers advise mixing with the water the contents of the drug "Tsedeks" for children (the instruction is silent on this method of use, so check with the pediatrician).

Children who have kidney disorders, the doctor determines his scheme of taking the medicine. In any case, when making a diagnosis, it is necessary to tell the doctor about allergic reactions to medicinal components, congenital diseases and taking any medications at the time of the disease.

Analogs and interaction with other drugs

Despite the long list of side effects of the drug "Tsedeks", the instruction does not give a detailed description of the interaction of the drug with other medicines. Thus, with simultaneous administration of an antibiotic with antacids, ranitidine and theophylline, there are no signs of mutual influence until now.

Sometimes cephalosporins can alter prothrombin activity, so patients in this category need to measure MNO and prothrombin time, and also administer vitamin K before taking Zedex. The dosage (40 μg / ml) of this drug in pharmacological studies did not give any information about any violations in the chemical and laboratory parameters of the blood.

However, people with penicillin allergy often cross-react to cephalosporins, resulting in anaphylaxis. Persistent diarrhea can also indicate severe violations, which requires immediate medical intervention.

Most mothers ask you to replace the antibiotic "Tsedeks" for children (suspension), the reviews do not indicate a negative effect on health, but the high price of this medication. The analogues of this drug in terms of the spectrum of action are Azran, Axon, Bestum, Vicef, Iksim Lupine, Kefotex, Lendacin, Medaxon, Ortax, Sulmover, Supraks, Chizon, Cetax, Cefaxon, and Cefodox. However, without consulting a doctor, do not replace the drug.

Summarizing

Thanks to the active substance ceftibuten this antibiotic of the third generation has antibacterial and antimicrobial effect. Despite the long list of side effects, an accidental overdose does not lead to intoxication. If this happens, it is necessary to urgently wash the stomach and help the doctor.

If the child has at least some disposition to an allergy, then be careful when taking the antibiotic "Tzedeks." Instruction (suspension, capsules are taken, is not important) warns that this drug can not be used by people who have an allergy to penicillin or antibiotic components, metabolic disorders of carbohydrates. With caution appoint this drug to people who have violations of the kidneys and digestive system.

The antibiotic is produced in powder for the preparation of a suspension for children from half a year to 10 years (weighing up to 45 kilograms) and in capsules for adolescents and adults. This is an expensive but effective remedy for the treatment of diseases of the respiratory tract, urinary system, ENT organs. Therefore, the doctor can ask for an analogue of an antibiotic, which has the same pharmacological action as the "Tsedeks" (suspension).

The instruction (for children of all ages, the treatment regimen is given in milligrams) for the use of an antibiotic for various diseases is difficult for an average person to understand. Therefore, it is necessary to carefully listen to the recommendation of the attending physician. Together with the antibiotic, it is also necessary to take medications to restore the intestinal microflora (preparations "Normobakt", "Linex", "Hilak", "Bifidumbacterin", "Lactobacterin" - to choose from) and preventive antiallergic medicines (such drugs as "Fenistil" Suprastin "," Zodak ").