The drug "Doxycycline", analogues and their action.

"Doxycycline" refers to antimicrobials for systemic use. Just like Doxycycline itself, the analogs of this drug are part of the tetracycline group. They have a spectrum of a fairly broad action aimed at fighting microbes.

The most famous analogues of the drug "Doxycycline" are "Unidox solute", "Doxycycline gidlochloride", "Doxibene", "Doxycycline-darnitsa" and some others. Quite often you can observe how a person doubts what to buy, "Doxycycline" or "Unidox", for example. It should be noted that the pharmacodynamics of these drugs is the same. Thus, they are all active against Gram-positive (Stamphylococcus spp., Streptococcus spp., Actinomyces Israeli, Clostridium spp., Listeria monocytogens, Bacillus anthracis) and Gram-negative (Neisseria gonorrhoeae, Vibrio cholerae, Bordetella pertussis, Yersinia spp., Enterobacter spp. Klebsiella spp., Escherichia coli, Salmonella spp., Shigella spp.) Of microorganisms. Sensitive to Doxycycline and its analogues Mycoplasma spp., Rickettsia spp., Treponema spp., Borrelia burgdorferi, Chlamydia spp., Some protozoa (including Entamoeba histolytica, Plasmodium falciparum). The most sensitive to the analogues of "Doxycycline" Haemophilus influenza (91-96%) and intracellular pathogens.

The only significant detail, which differs from the drug "Doxycycline" analogs - is that it is less than other tetracycline agents worsen intestinal flora, and also has a longer duration of action and more complete absorption. Antibiotics from a number of tetracyclines penetrate into the cell and suppress the reproduction of pathogens located there. According to the degree of bacterial activity, the drug "Doxycycline hydrochloride" surpasses all other tetracyclines, including natural ones.

Like the drug "Doxycycline," its analogs have the following indications for use:

- infectious ENT organs;

- an infection of the respiratory tract;

- infection of the genitourinary system;

- infection of soft tissues and skin;

- infection of biliary tract and gastrointestinal tract;

- osteomyelitis, brucellosis, whooping cough;

-syphilis, yersiniosis, malaria, yaws, ky fever, legionellosis, typhus, rickettsiosis, Lyme disease, chlamydia of different localization, bacillary and amoebic dysentery, cholera, tularemia, actinomycosis;

- in the general therapy - granulocyte erlichiosis, leptospirosis, psittacosis, trachoma, ornithosis;

- subacute septic endocarditis, sepsis, peritonitis.

Prohibited the use of "Doxycycline" with a strong sensitivity to tetracyclines, severe liver failure, porphyria, during pregnancy, lactation (for the period of taking the drug from breastfeeding should be abandoned), at the age of children under 12 years. With caution should take this drug to people who have a violation of the liver, leukopenia.

The drug "Doxycycline" can have side effects on:

- the nervous system (toxic effect on the central nervous system, intracranial pressure above the norm);

- Hearing organs (noise appears in the ears);

- digestive system (enterocolitis, vomiting and nausea, diarrhea or constipation, gastritis, dysphagia, glossitis, esophagitis, expression of the stomach and duodenum);

- from the side of the cardiovascular system (edema, tachycardia);

- hematopoiesis (thrombocytopenia, eosinophilia, hemolytic anemia, neutropenia, porphyria);

- reactions indicating allergies (skin flushing, itching, anaphylactoid reactions, maculopapular rash, Stevens-Johnson syndrome, anti-neuropathy edema);

- Other (hepatitis, jaundice, myalgia, arthralgia, photosensitization, strong discoloration of tooth enamel, inflammation in the area of the anogenital zone, candidiasis, dysbiosis).

In case of an overdose of Doxycycline, you may notice the following symptoms: hepatotoxicity, more pronounced side effects. In this case, you should immediately resort to medical care, cancel the drug and conduct symptomatic therapy (since there is no specific antidote), it is also necessary to maintain and control how vital functions proceed.