The drug 'Clarithromycin'. Analogues, indications and contraindications

The drug "Clarithromycin" is an antibiotic from the group of semisynthetic macrolides of the 3rd generation. Is able to suppress protein synthesis. In this article you will learn useful information about the drug "Clarithromycin" - analogues, indications and contraindications, possible side effects from the application.

The form of the drug "Clarithromycin" - 500 mg, 250 mg - in a tablet form. 10 tablets are produced in a plastic container or a plastic bag.

With respect to which microorganisms is the drug "Clarithromycin" active?

• Intracellular: Chlamydia pneumoniae, Legionella pneumophila, Mycoplasma pneumoniae, Chlamydia trachomatis, Ureplasm urealyticum;
• Gram-positive bacteria: Streptococcus spp. (Including Streptococcus pneumoniae and pyogenes), Staphylococcus spp, Corynebacterium spp, Listeria monocytogenes;
• Gram-negative bacteria: Haemophilus influenzae and parainfluenzae, Moraxella catarrhalis, as well as Vordetella pertussis, Neisseria meningitidis, Haemophilus ducreyi, Borrelia burgdorferi, Campylobacter spp., Helicobacter pylori;
• Anaerobes: Bacteroides melaninogenicus, Peptococcus spp., And also Clostridium perfringens, Eubacterium spp. Propionibacterium spp;

The drug "Clarithromycin", its analogs. Indications for use

• Diseases of the respiratory system: laryngitis, sinusitis, tonsillitis, tracheitis, pharyngitis, bronchitis, pneumonia bacterial.
• Diseases of the skin and soft tissue: wound infection, impetigo, furunculosis, folliculitis.
• Diseases of the digestive system: gastric ulcer and duodenal ulcers.

The drug "Clarithromycin", its analogs. Contraindications for use

Hypersensitivity to the active substance; Simultaneous administration of preparations "Cisapride", "Pimozide", "Terfenadine" and "Astemizol"; Porphyrin disease. The drug "Clarithromycin" and its analogs should be used with caution in the treatment of elderly people and children under six months (since the safety of the use of the medication is not established), as well as in the presence of the patient's deficiency - renal or hepatic.

During pregnancy, the drug "Clarithromycin" can be used in the absence of an alternative only if the expected benefit will exceed the risk of unwanted effects in the future child. Studies that would confirm the safety of the use of this antibiotic in the period of gestation were not carried out. When lactation during treatment, it is necessary to stop breastfeeding the baby.

Side effects of the drug "Clarithromycin" and its analogues

Possible side effects from the following systems:

• Nervous: headache, anxiety, dizziness, fear, insomnia, tinnitus, nightmares, changes in taste: less often - hallucinations, disorientation, psychosis, confusion, hearing loss after withdrawal, paresthesia;
• Digestive: a feeling of nausea, vomiting, discomfort in the abdomen, diarrhea; Glossitis, stomatitis, jaundice cholestatic: less often - pseudomembranous enterocolitis, hepatitis, hepatic insufficiency;
• Cardiac and vascular: thrombocytopenia, leukopenia; Rarely - increased QT-interval, ventricular arrhythmia, paroxysmal ventricular tachycardia, ventricular fibrillation;
• Urogenital: renal failure , interstitial nephritis .

It is also possible to develop allergic reactions: skin rash, itching, erythema malignant, exudative, anaphylactic shock. In rare cases, the resistance of microorganisms to the drug "Clarithromycin" and its analogues develops.

The drug "Clarithromycin" - analogs.

Each analog contains the same active substance - clarithromycin.

Excipients can be: magnesium stearate, starch, purified talc, aerosil, microcrystalline cellulose, polyvinylpyrrolidone, sodium starch glycolate, hydroxypropylmethylcellulose, titanium dioxide, various dyes.

To date, there are the following analogues of the drug "Clarithromycin": medicines Klabaks, Klacid, Clerimed, Clarithromycin Verte, Arvitsin Retard, Crixane, Binoklar, Claricit, Clarbact, , "Clasina", "Frimilid", "Clarexid", "Claritrosin", "Clacid SR", "Ecositrin", "Clarithromycin-Protech", "Seydon-Sanovel", "Arvitsin".

When choosing an analogue, you should consult your doctor. When buying a patient should be wary of a too low price and an unknown producer.