"Siofor 500"

"Siofor 500" - a drug that is used to reduce blood glucose levels in patients with diabetes mellitus. The drug is produced only in tablet form, it is covered with a special coating and is intended for internal reception.

The active substance that is used in the preparation "Siofor 500" is metformin hydrochloride. The auxiliary components include magnesium stearate, povidone, hypromellose, titanium dioxide, macrogol 6000.

Pharmacological action of this drug is due to belonging to the biguanide group. When directly entering the bloodstream, it manifests a hypoglycemic effect (decrease in glucose concentration). "Siofor 500" does not affect the secretory function of the pancreas, so when it acts, the level of insulin does not change. The active substance metformin inhibits glycogenolysis and gluconeogenesis, so the production of glucose in the liver cells is reduced. It also increases muscle sensitivity to insulin, inhibits the absorption of this substance in the intestine. Similar effects sometimes allow using "Siofor 500" for weight loss. The drug has a number of other useful properties, which include stimulation of intracellular synthesis of glycogen, increase of transport capacity of membrane proteins of glucose, reduces the level of cholesterol, triglycerides.

The maximum concentration of the drug after taking it is observed after two hours. Food intake reduces this indicator. The bioavailability index is fifty percent. The drug is excreted in the urine. Half-life of all components is six and a half hours. With a decrease in the functional activity of the kidneys, this indicator increases. In addition, the plasma content of the active substance increases the drug.

The dose of the drug is determined individually. It is determined by the level of blood glucose concentration. Treatment is carried out according to the principle of a gradual increase in the dose. The drug should be taken during eating, washed down with large amounts of liquid, and not chewed. Two-time administration is possible only at a dose that is more than one tablet a day. The duration of the course of treatment is determined by the doctor. The missed drug intake can not be compensated for by the use of significant amounts of tablets. The dose of the drug should be immediately reduced when metabolic disorders occur.

"Siofor 500" is a drug that should be used under the supervision of a doctor. In adverse cases, complications develop, including lactacidosis, respiratory disorders, weakness, vomiting, nausea, drowsiness, diarrhea, hypothermia, abdominal pain, reflex reduction in heart rate, confusion, loss of consciousness. In addition, the typical occurrence of megaloblastic anemia, allergic reactions.

During a doctor's consultation, it is necessary to clarify the contraindications to the use of the drug. The main ones are diabetic ketoacidosis, to whom, violation of renal, hepatic function, myocardial infarction, cardiovascular insufficiency, infectious diseases, traumas, surgeries, hypersensitivity to individual components. It is forbidden to use the drug a few days before the radioisotope studies.

An important contraindication to the use of the drug is the period of pregnancy, lactation. "Siofor" and alcohol are also incompatible, this combination may be the cause of the development of severe metabolic complications, the elimination of which will require the elimination of provoking factors and the use of symptomatic therapy.