Resistant ovarian syndrome: symptoms, treatment, prevention

Resistance ovarian syndrome is the least studied form of female pathology. Most often this disease appears in 25-35 years. Characterized by the temporary absence of menstruation with an elevated level of gonadotropic hormones of the pituitary gland.

Definition

The essence of the ailment lies in the fact that the ovaries cease to fulfill their immediate function. Most often the disease progresses and ends with menopause. The peculiarity of pathology is manifested in infertility and the absence of the menstrual cycle. At the time of the disease, various forms of amenorrhea often develop. In this period there is an overestimated level of gonadotropic hormones in the pituitary gland, since the body still tries to start the ovaries. However, they do not begin to work, as insufficient amount of progesterone and estrogen are allocated. The first time the problem started talking in 1959, then the scientists described the signs of a syndrome of resistant ovaries. But still this topic is still poorly understood, and the reasons for the occurrence are still not completely defined.

Kinds

In medical reference books there is no clear classification of this pathology. Although some experts identify three options for the development of the disease:

1. Genetic predisposition of defects in the follicular apparatus.
2. The autonomic nature of appearance - at the time of antibody production, the sensitivity of follicle-stimulating hormone receptors is blocked.
3. When using cytotoxic drugs and immunosuppressants.

Symptoms

The syndrome of resistant ovaries can most often be determined from the listed ailments:

• High figures of LH (luteinizing hormone) and FSH (follicle-stimulating hormone) and low estradiols;
• Amenorrhea - absence of menstruation;
• Depletion of the vaginal mucosa and vulva;
• Ovaries with a large number of follicles with normal size and a thin endometrium of the uterus;
• Transfer of severe viral infections and stress;
• The menstruation begins to become irregular, and then completely disappears.

The development of the disease most often occurs after 5-10 years from the first cycle. All examinees note that hot flashes to the head are observed at night and daytime. Painful feelings in the abdomen appear spontaneously, without any reasons for this. Most often, women who have a syndrome of resistant ovaries have painful menstruation and postpartum complications.

When a patient comes to see a doctor with complaints of soreness at the bottom and absence of menstruation after viral infections, examination and tests performed most often show that she took sulfanilamides in large quantities, which could provoke the appearance of a diagnosis.

Causes

Nowadays the factors that influence the formation of pathology have not been fully studied. But there is a theory that the most likely source of the disease is genetic changes in the receptor node of the follicle. Most scientists argue that the syndrome of resistant ovaries, the symptoms of which are different and ambiguous, most often affect such ailments:

• baldness;
• Autoimmune thyroiditis (inflammation of the thyroid gland);
• Myasthenia gravis (muscle weakness and fatigue);
• diabetes;
• Thrombocytopenic purpura;
• Viral infections (most often mumps);
• Autoimmune anemia.

The main reasons for development include the following factors:

• Irradiation with oncology;
• Use of immunosuppressants and cytostatics;
• Operative intervention in the ovaries.

In addition to all this, pulmonary tuberculosis and sarcoidosis cause ovarian tissue damage, which often leads to the development of pathology. The ailment can also carry a genetic character and appear after severe stress and constant nervous overloads.

Diagnostics

The symptomatology of this disease is closely related to such ailments as gonadal dyscrasia and ovarian malnutrition. Therefore, only with a comprehensive study of complaints and data from the laboratory of clinical studies is determined by the presence of ailment. Most often, at the time of the initial examination, one can notice a weakly positive "pupil" phenomenon, mastopathy in the fibrocystic type, depletion of the anterior part of the mucosa of the vulva and vagina and its pronounced hyperemia. With echography, laparoscopy and gynecological examinations, a minimal decrease in the size of the uterus is observed. In order to confirm the syndrome of resistant ovaries, doctors prescribe a biopsy of the epididymis. A histological examination is performed to detect parenteral and pyramidal cells. If you undergo a hormonal examination, you can set the level of LH and FSH in blood plasma, which is often high and does not coincide with the norm. A low concentration of estradiol is found. Special attention is paid to hormonal tests, it is noted that the first test shows the most frequently positive gestogen, and in subsequent - negative.

Therapy

Medical practice very often deals with such a problem as the syndrome of resistant ovaries. Treatment is always ambiguous, since the nature of the onset of the disease has not been fully understood. Usually HRT is prescribed (hormone replacement therapy) and correction of estrogen deficiency. The basis of the procedures is the restoration of the menstrual cycle and a decrease in the level of gonadotropic hormones.

Often, doctors prescribe drugs such as "Trieskvens", "Feston", "Klimen", "Premella-cycle", "Klimonorm", "Divina", "Klimodien", "Livial" and "Cliogest". Due to the nature of the course, the patient must undergo ultrasound of the pelvis every year. Controlling the analysis of blood, lipoproteins and cholesterol helps to form and know the beginning of a new stage of therapy. Due to densitometric studies, osteoporosis can be excluded.

As well as drug treatment is effectively combined with non-traditional:

• Carrying intravaginal and celiac ultraphoonophoresis;
• Resort rest;
• Acupuncture of ovarian region receptors;
• Reception of vitamin E.

Data on the results of such therapy are very ambiguous. But the doctors still state an increase in the number of menstrual secretions and follicles, LH and FSH are activated. The estrogens start to rise in the blood. After the restoration of menstruation, normal ovulation often does not occur, and the patient can often give birth to a child by IVF (in vitro fertilization).

To date, gynecology has not very well studied why there is a syndrome of resistant ovaries. Hypergonadotropic amenorrhea is a serious disease, and at the moment there is no main list of recommendations for its prevention and treatment. The most correct is considered to exclude adverse factors and every year to undergo examinations, especially if there is a violation of the menstrual cycle.

ethnoscience

It is often used as preventive therapy. It is recommended to constantly take vitamin E, which is found in products such as hazelnuts, peanuts, sprouted wheat and walnuts. Return the menstrual cycle will help the component of lecithin, which is found in legumes, caviar and cauliflower, and as is known, it is his lack indicates the syndrome of resistant ovaries. Treatment with folk remedies, as well as phytopreparations perfectly complement the therapeutic effect.

Most often these are herbal collections, which have analgesic properties and regulate the cycle well:

1. To prepare the composition, you need to mix 30 grams of peppermint leaves, valerian root and 40 grams of chamomile. The prepared mass is poured with boiling water and one glass is used in the evening and in the morning.
2. Infusion of berries of viburnum and blackberry helps the ovaries, for this they need to take a few glasses a day.
3. To improve the menstrual cycle is eaten by a pair of cloves of garlic.

Infertility

The first stage of treatment includes the normalization of the endocrine system, namely, the correction of the thyroid gland, adrenal gland function and the treatment of diabetes mellitus.

Then it is required to conduct:

• Spermogram of the spouse (3 times for 7 weeks), in order to exclude the factor of male infertility;
• Echosalpigography (determination of patency of the fallopian tubes);
• Postcoital test - to confirm absence of immunological infertility;
• Hysteroscopy (check for intrauterine pathology).

Next, drugs are used that begin to stimulate the follicles, and then continues to receive for the appearance of ovulation. Syndrome of resistant ovaries and pregnancy are quite compatible, as in 60-70% of cases, infertility can be won with the help of drugs.

Prevention

Since to date, modern medicine has not completely studied the process of the appearance of the disease, it is very difficult to identify certain measures that could contribute to its prevention. Although many experts suggest, if possible, not to use drug intoxication and not to resort to exposure to radiation. It is recommended to lead a healthy lifestyle and to treat gynecological diseases in time, so that there is no syndrome of resistant ovaries.

Prevention is also in the fact that with the most minor disruptions in the menstrual cycle, you need to visit a doctor and undergo all the required examinations. This will help prevent the development of a variety of pathologies and preserve women's health.

Consequences and Forecast

The main complication is the violation of the cycle and infertility, which are difficult enough to treat. And also the risk of early formation of age-related diseases is increased, as there is a shortage of estrogens and there is a chance of developing malignant tumors of the uterus.

The prognosis is quite favorable, and the menstrual function most often returns.