"Omeprazole" or "Ultop" - which is better? Description of drugs, indications and contraindications, prices

Treatment of ulcerative lesions of the gastric mucosa or digestive tract as a whole is a complex and lengthy process. This is due not only to the fact that hydrochloric acid, which is part of the gastric juice, slowly increases the mucosal defect, digesting its own tissues, but also by the association of the disease with the presence of the microorganism Helicobacter pylori. In order to prevent the expansion of the defect and to facilitate the speedy recovery of the patient, doctors prescribe "Omeprazole" or "Ultop". Which is better, we will discuss in this article.

Mechanism of action

Despite the fact that the drugs have a different name, the active substance in them is the same - omeprazole. What does this medicine treat and represent?

According to the chemical characteristics, this substance is practically insoluble in water, but very soluble in ethyl alcohol or methanol.

In clinical practice, omeprazole is used in a variety of drugs, including combined, as a means to treat ulcerative defects. "Omeprazole" or "Ultop" - which is better? Very often this question is asked by patients and doctors.

The mechanism of action is based on the suppression of the so-called proton pump - a specific transport protein, located in the cell membrane of the secretory cells of the stomach. By reducing the intake of hydrogen ions into the cytoplasm of such a secretory cell, the amount of hydrochloric acid produced by it decreases, and the acidity of the gastric juice decreases, which leads to a decrease in tissue destruction and favors the accelerated healing of the ulcer.

Pharmacokinetics

Omeprazole effectively inhibits both stimulated and basal production of hydrochloric acid, while providing a dose-dependent effect. With a single oral intake of 20 mg of "omeprazole" or taking a dose of "Ultop" - 20 mg, a decrease in acidity is observed already during the first hour, as the drug is quickly and well absorbed in the lumen of the intestine and enters the systemic circulation.

Despite the fact that the half-life of the active substance of the drugs is about two hours, the inhibition of production of hydrochloric acid is observed within a day after a single dose.

Omeprazole tropene, distributed through the mucous membrane of the stomach, liver and bile ducts, practically does not penetrate the blood-brain barrier and is completely associated with plasma proteins. The degree of binding to the latter can reach up to 90-95%.

Omeprazole is excreted mainly in the urine, with about 60-77% excreted as metabolites, such as hydroxyomeprazole and carboxylic acid. Most of the conjugates formed exhibit practically no antisecretory activity, except for sulfonomeprazole. Remaining in the body part of the drug is derived through the gastrointestinal tract with bile and fecal masses.

Of particular note is the pharmacokinetics of omeprazole in patients with hepatic insufficiency. By reducing the metabolism of the drug, its bioavailability reaches a maximum, and the half-life is extended to three hours. In patients with chronic renal failure, the excretion of metabolites of omeprazole is slowed down in accordance with the purification of plasma from creatinine.

Indications for use

Medicinal products "Omeprazol" and "Ultop" are indicated for use in the treatment of peptic ulcers of the digestive tract, hyperacid conditions (including gastritis), Zollinger-Ellison syndrome, postoperative conditions, reflux disease. These drugs can be recommended for the therapy of non-ulcerative dyspepsia, in the treatment of complications caused by non-steroidal anti-inflammatory drugs (analgesics, antipyretic drugs), as well as for treatment of uncomplicated heartburn that occurs no more than 2 times a week.

Despite the evidence in the instructions for the use of the drug "Omeprazole", which treats this drug, only a qualified specialist knows it well. Therefore, if the state of health worsens from the gastrointestinal tract, it is necessary to go to the polyclinic and not engage in self-medication.

Contraindications

All forms of the drug, including pills "Omeprazole", are contraindicated in the presence of patients with hypersensitivity to the drug, as well as children. Reduction of the secretory function of the stomach with hypoacidic conditions and atrophic gastritis is also a contraindication to the appointment of omeprazole.

Side effects

About the preparations "Omeprazol" and "Ultop" reviews say that, due to the decrease in the acid-forming function of the stomach, from the gastrointestinal tract, the occurrence of constipation, flatulence, constipation, vomiting and pain in the epigastric region is likely. Less frequent is candidiasis, dry mouth, development of atrophic or hypoacid gastritis, intestinal polyposis.

From the side of the nervous system (afferent impulses) there may be a headache, feelings of malaise, feelings of anxiety and anxiety, depression and mental disorders. It is not excluded the appearance of visual function disorders, which can become permanent.

Allergic reactions to taking omeprazole are rare. Situationally, there may be urticaria, itching of the skin. With a low frequency there is a spasm of glandular cells of the bronchi, development of Quincke's edema with further progression in the type of anaphylactic reaction and development of shock state. Casuistically noted the development of gynecomastia, the appearance of pain in the chest.

Mode of application

"Omeprazole" is taken on an empty stomach, washed down with water. In a special category of patients, it may be difficult to swallow the capsules of the drug. In this case, the capsule is recommended to be opened, and from its contents prepare a suspension on a water basis. Take this suspension should be no later than half an hour after preparation. The daily dosage, single dose, as well as the course of therapy with the drug is prescribed by the attending physician.

Features of use during pregnancy and breastfeeding

There are no data on the safety of omeprazole in pregnant women. The medicinal substance can be shown by the vital indications. The effect category on the fetus is not defined.

If there is a need to prescribe omeprazole during breastfeeding, then for the period of treatment the latter should be abandoned, since the drug is able to penetrate into breast milk.

Drug Interactions

Both "Omeprazole" and "Ultop" reduce the bioavailability of all drugs, the absorption of which depends on the acidity of the gastric juice. Also, the release of drugs, the metabolism of which is carried out in the liver, is slowed down.
A prepared sterile injectable solution of omeprazole can be used for 12 hours under the condition that a physiological solution of sodium chloride is used as a solvent and for several hours after preparation, if a solution of dextrose is used as a solvent. With other solutions, omeprazole is not compatible.

With concomitant treatment with the drug "Warfarin", one should monitor the level of anticoagulant in the blood plasma daily or monitor prothrombin time in a timely manner .

Treatment of poisoning and overdose

Symptoms of an overdose of omeprazole are manifested in the form of dry mouth, dizziness, headache and visual impairment. When poisoning is possible confusion, the appearance of drowsiness, palpitations, sensations of tides to the face.

The treatment of poisoning is symptomatic, aimed at removing the drug as quickly as possible from the body. The specific antidote is unknown. Due to the high degree of binding to blood plasma proteins, the use of dialysis methods of detoxification is irrational.

special instructions

Since drugs are used to treat ulcerative lesions of the stomach and duodenum, the etiologic factor of which is Helicobacter pylori infection, it is recommended that antibiotic medicines be used for the eradication of microorganisms.

Before starting the use of the drug, the patient must refute the malignant tumor diseases of the gastrointestinal tract, since the appointment of "omeprazole" can mask the symptoms of these diseases and make it difficult to diagnose early. It is necessary to exclude infectious parasitic diseases, as well as assess the functional capacity of the liver and kidneys.

"Omeprazole" or "Ultop" - which is better?

It is difficult to answer this question unequivocally, because the active substance in both cases is omeprazole. Let's consider the forms of the release of the drug "Ultop". Capsules are available in dosage of 10, 20 and 40 mg, and also in the form of lyophilized powder (40 mg in one bottle) for the preparation of an injection solution.

"Omeprazole" is presented in the pharmaceutical market in the form of capsules of 10, 20 and 40 mg of omeprazole in one capsule, and also in the form of lyophilized powder (40 mg in one bottle) for the preparation of injection solutions. A lyophilized powder with a solvent in one package is also available. In addition, the preparation can be purchased in the form of a sachet (bags of powder) for the preparation of an oral suspension. It is rare to find tablets "Omeprazole" (pellets) with a similar content of drug substance.

With regard to reviews of these drugs, they are positive, since omeprazole is an effective drug that reduces the secretory activity of the stomach. The drug is so effective that even doctors ask the question: "What is better than omeprazole?" However, the opinions vary among patients. Quite often, the remarks about Ultop give evidence of constipation after taking, headache and nausea.

Cost of drugs

Undoubtedly, the cost of medicines will depend not only on the pharmacy network in which they are sold, but also on the remoteness of the pharmacy from the medical institution and, of course, on the drug manufacturer itself. On the drug "Ultop" the price ranges from 212 to 360 rubles per package. The final cost depends on the dose and the number of capsules in the package. On the drug "Omeprazole" the average price is from 80 to 140 rubles. The price also depends on the dose and the number of capsules in the package.

Conclusion

Only the attending physician should prescribe "Omeprazole" or "Ultop". What is best of these medicines, the competent specialist knows, and his decision should be based on the indications for the appointment and the condition of the patient. It should be borne in mind that often the decisive factor in the choice of a drug is its cost.

Patients should pay attention to "Omeprazole", the price of which is much lower than the analogue of "Ultop". Those who are willing to pay more can look at the analogues of this drug. Despite the somewhat high cost of Ultop, the price can justify the degree of purification of the drug, as well as possible additional modulating additives in the drug itself.

Whatever it was, it is always worth remembering the golden rule: do not engage in self-medication. Early diagnosis is the key to successful treatment!