"Nolycin" - an antibiotic or not? Tablets "Nolitsin" from what?

Is the preparation Nolitsin an antibiotic or not? The answer to this difficult question will be given in the article presented. Also, we will tell you about the diseases in which the agent is prescribed, whether it has side effects and contraindications, and also discuss how much it costs and what substances it includes.

Packaging, form, composition of the medicine

Tablets "Nolitsin" (from which they help, we'll explain later) contain an active substance such as norfloxacin. As for the auxiliary components, magnesium stearate, anhydrous colloidal silicon dioxide, microcrystalline cellulose, purified water and povidone are used as such.

It should also be noted that the shells of the tablets under consideration include hypromisole, propylene glycol, talc, dispersed yellow dye (E 110) and titanium dioxide.

The drug "Nolitsin", the price of which is indicated below, is produced in blisters of 20 or 10 tablets, which are placed in cardboard packs.

Pharmacological properties of the medicinal product

"Nolitsin" medication is an antibiotic or not? Many patients ask this question to their doctors. As is known, the active substance of the drug in question is norfloxacin. It has an antimicrobial effect on strains of staphylococci, as well as Neisseria, Klebsiella, Enterobacterium, Escherichia coli, Legionella, Chlamydia, Salmonella, Shigella and other pathogens of infectious diseases.

The mechanism of action of the drug is based on the interaction of the active substance with the DNA-gyrase (i.e., the enzyme of microorganisms). Such influence leads to destabilization of the DNA chain, as well as subsequent death of bacteria.

So the drug "Nolitsin" - an antibiotic or not? From all of the above, we can safely conclude that this medication is an antibiotic, as it has a negative effect on harmful microorganisms.

The antimicrobial effect of tablets can last about 12 hours. As a rule, such a drug is prescribed for diseases that were caused by enterococci and other mycobacteria.

Pharmacokinetics of the drug

Now you know what Nolitsin is. Antibiotic or not this medication, we also found out. Now I want to tell you about whether the drug in question is absorbed into the systemic bloodstream.

According to the statements of pharmacists, the active ingredient of this preparation is absorbed fairly quickly in the digestive system. Its peak concentrations are observed already after 1-2 hours after taking the tablets. The bioavailability of the drug is 30-40%. Approximately 15% of the active substance binds to plasma proteins.

Medication in unchanged form is excreted through the renal system. And only a small part of it goes through the digestive tract.

In people with renal pathology, the pharmacokinetic properties of the drug may appear differently.

Indications for use of the drug

In what cases are Nolicin tablets prescribed? From what do they help? According to the attached instructions, the medication is prescribed for the treatment of diseases of the genitourinary system, which are of an infectious or inflammatory nature:

• urethritis;
• Chronic prostatitis of bacterial origin;
• Endometritis;
• cystitis;
• Cervicitis;
• Uncomplicated form of gonorrhea;
• Pyelonephritis.

What other purposes do you use Nolitsin? Indications for taking this medication can be as follows:

• Shigellosis;
• Bacterial gastroenteritis;
• Prevention of diarrhea;
• Salmonellosis;
• Prevention of septic complications in patients with neutropenia.

Contraindications for use

The reception of "Nolycin" should be prohibited under the following conditions:

• Impaired cerebral blood supply;
• Intolerance to fluoroquinolones;
• Epileptic syndrome;
• Fruit bearing;
• Changes (atherosclerotic) in the vessels of the brain;
• Congenital deficiency of the G6PD enzyme;
• Allergic reactions to acetylsalicylic acid.

It should also be noted that the drug in question is prohibited in pediatric practice.

How to take Nolycin?

Take the tablets "Nolitsin" should be inside, washed down with plain water.

With infectious diseases of the genitourinary system, the drug is prescribed twice a day for 400 mg. The duration of such therapy is 7-10 days.

Therapy of uncomplicated cystitis is carried out for 4-7 days.

Recurrent infectious diseases of the urinary tract (chronic) should be treated 12 weeks. As for acute gastroenteritis of bacterial origin, with this diagnosis, the drug is prescribed twice a day for 400 mg for five days.

With proctitis, cervicitis, pharyngitis and urethritis, the tablets are taken once in 400 mg.

Signs of an overdose

After taking higher doses of the drug, the patient exhibits the following symptoms: intense vomiting, dizziness, nausea, drowsiness, cold sweat. Therapy of such conditions includes gastric lavage and forced diuresis.

Side effects after taking pills

Are there adverse reactions after taking Nolicin? Instruction, doctors' reviews indicate the following undesirable phenomena:

• nausea;
• Hypercreatininaemia;
• Vomiting;
• Glomerulonephritis;
• Bitter taste in the mouth;
• Polyuria;
• Epigastric pain;
• Urethral bleeding;
• Impaired appetite;
• Crystalluria;
• Diarrheal syndrome;
• Dysuria;
• Pseudomembranous enterocolitis;
• albuminuria;
• Increase in ALT and AST.

Also, patients may have headaches, hallucinations, pruritus, arrhythmia, vasculitis, insomnia, tachycardia, swelling, syncope, exudative erythema and urticaria

Very rarely, people taking the drug "Nolitsin", recorded changes in blood counts, candidiasis, arthralgia, lowering of hematocrit, fear of light and chemosis.

Drug Interactions

This drug reduces the effectiveness of a drug such as Nitrofuran, and increases the concentration of indirect anticoagulants and Cyclosporine. It should also be noted that norfloxacin reduces the overall clearance (about ¼) of theophylline.

With the joint use of Nolicin tablets with drugs that reduce the epileptic threshold, epileptic seizures may worsen in patients .

With the simultaneous administration of antihypertensive drugs, there is a sharp drop in pressure.

Antacids reduce the absorption of "Nolitsin".

The use of medicines intended for general anesthesia requires special control of heart rate, blood pressure and heart function.

Special instructions on the use of medicament

Before the appointment of the antibiotic "Nolitsin" should determine the sensitivity of the flora to the active substance of the drug.

With this diagnosis, like pyelonephritis, the medication in question should be prescribed together with herbal preparations (for example, with Kanefron).

During treatment, patients should receive a large amount of water (under the control of diuresis).

During therapy with Nolicin, it is advisable to avoid prolonged exposure to direct sunlight.

If the patient has pain in the tendons or signs of tendovaginitis appear, the drug should be immediately discontinued.

During treatment with norfloxacin it is desirable to avoid intense physical exertion.

The preparation "Nolitsin": price and analogy

Analogues of the drug under consideration are the following drugs: Loxon-400, Norfacin, Norbaktin, Sofazin, Norilet and Renor.

The price for Nolicin tablets depends on their quantity in the package: 10 pieces - 150 rubles, 20 pieces - 305 rubles.

Reviews about the drug

Reviews about the drug "Nolitsin" are mostly positive. It is especially effective in cystitis. According to the patients, the taken preparation quite quickly eliminates all unpleasant signs of the mentioned disease (pain syndrome, rezi, frequent urination).

Thus, it can be safely concluded that the drug "Nolitsin" is an effective and inexpensive antibiotic, intended for the treatment of diseases of the genitourinary system. However, it should be mentioned that some patients claim that this drug can cause a rather large number of adverse reactions. In connection with this, the medicine must be taken only as prescribed by the doctor and after a detailed study of the instructions.