"Nitroglycerin" from what? Side effect of "Nitroglycerin"

At present, the shelves in the pharmacies are simply bursting with the amount of medicines that are stored on them. Many drugs you can buy, only having on hand a prescription written by a doctor, but most of the goods from the available range will be sold without having one. "Nitroglycerin" refers to free-selling medicines. From what he helps, you can learn from this article. Despite the fame, treat his reception with extreme caution.

Information about the preparation

Nitroglycerin (a group of nitrates) quickly found application. Use it began in the late 19 th century, after the discovery of the Italian Ascanio Sobrero. At first it was the production of explosives.

After lengthy observations of workers in the workshops for the production of explosives, Dr. Merrill concluded that nitroglycerin vapor has an impact on human health.

A little later it was established that this substance can be used and for medical purposes to treat certain diseases. For example, after taking it, you can remove the spasm of the heart vessels. At attacks of a stenocardia there were enough few drops of a preparation to stop it.

So gradually nitroglycerin began to be used in medical practice.

Today, if you ask any person about "Nitroglycerin": "What should it be used for?", Almost everyone will say that it is indispensable for heart attacks. Have not yet come up with another drug that would so quickly relieve pain with angina pectoris.

Forms of the preparation

"Nitroglycerin" can be attributed to those grandiose discoveries in the world of pharmacology, which happen infrequently. During its use, and this is more than 100 years, have not invented a more effective medication for "angina pectoris".

Manufacturers produce various forms and packages, but the active substance remains the same. Now in pharmacies you can find quite a large assortment. "Nitroglycerin" is released in the form of tablets, which must be placed under the tongue. This is the very first form of the drug.

Now the nitroglycerin plaster has become fashionable, which is enough to stick to the skin or mucous membrane, so that the active substance starts its healing work. Even more advanced is Nitroglycerin Aerosol. Despite the fact that all these preparations contain the same substance, their cost can vary within fairly wide limits.

"Nitroglycerin" - mechanism of action

Many, probably, are wondering about the secret of this instantaneous action of this medication in heart attacks. The whole answer lies in the principle of the drug. Pain in angina occurs as a result of acute oxygen deficiency in the heart muscle. You can remove it only in several ways:

1. Increase the flow of oxygen to the heart.
2. Reduce the frequency and strength of the heart rate to reduce oxygen consumption.

All this is quite capable of carrying out "Nitroglycerin". After its administration, the production of nitric oxide increases, which expands the vessels, especially the veins. This leads to a decrease in the flow of venous blood to the heart muscle, and the frequency of contractions and their strength decrease. If less work, then oxygen is required less.

But the drug "Nitroglycerin" also increases the flow of oxygen to the heart by expanding the coronary vessels, and this is stronger precisely in the place of ischemia, which leads to a rapid arrest of the attack of angina.

The effect of taking the medicine can be observed in a few minutes. As soon as the drug is expelled from the blood. After 40-45 minutes, there will be no trace of it.

Indications for use

There are a number of diseases in which "Nitroglycerin" is recommended. The application may need a one-time or a prolonged one. Among the indications are the following:

• Any manifestations of angina pectoris.
• Spasm of the coronary vessels, which can obstruct intravascular studies.
• Myocardial infarction, especially on a background of hypertension.
• Heart failure.

• Before neurosurgical operations can use "Nitroglycerin". Applying it artificially will lower the pressure.
• Spasm of the arteries in the retina of the eyeball.
• Dyskinesia of some parts of the digestive system.

The doctor can recommend the use of any form. You can choose the one that is more convenient for you.

When else can I take Nitroglycerin?

It turns out that this medicine can be used not only in times of cardiac pain, but also in some other cases. For example, to prevent an attack, if you have physical work or emotional stress is foreseen.

Often it is taken by patients with a diagnosis of "angina" when they climb the stairs to the upper floor of a multi-storey building. It is recommended to take it before going uphill, especially in winter, frosty and windy weather.

You can not be surprised if the doctor will write out "Nitroglycerin" for pancreatitis or biliary colic attacks. The recipe is in Latin, but the pharmacists in pharmacies are well versed in such records. This appointment can be explained by the fact that this drug perfectly removes the spasm of smooth muscles of the digestive tract.

Proper medication

Despite the great popularity of this drug, it must be remembered: it is still a cure, so it must be taken according to certain rules. Only in this case can guarantee security.

The most effective and fastest way to help is the "Nitroglycerin" pill put under the tongue. Since there are many blood vessels in the oral cavity , the medicine is almost instantly absorbed into the blood, and relief comes.

If you decide to take the tablet "Nitroglycerin", then before it is better to sit down. Some may become dizzy, and in exceptional cases, there may be fainting.

In old age, it is better to take a reception in a supine position. At the time of attack, the pill should act after a couple of minutes. If the pain does not let go, then you can take one more. If after 15 minutes the pain does not pass, then you'll have to call a doctor, otherwise it's not far until the myocardial infarction.

If in your medicine chest "Nitroglycerin" in the form of drops, then during a heartache, you can drop 2-4 drops on a piece of sugar and keep it under the tongue until it dissolves. Some manage to drip directly into the tongue or even lick off the bubble plug.

Do not engage in self-medication, even if you are familiar with "Nitroglycerin." From what it is recommended to use - you know something, but the wrong dosage is fraught with serious consequences.

Varieties of "Nitroglycerin"

Everyone knows that this drug acts quickly, but not for long. At the present time, forms have been created that are capable of exerting their curative effect within a few hours. Such drugs include nitroglycerin prolonged, for example, "Sustak", "Nitrogen", "Trinitrolong".

They are recommended to be used in advance, they are able to prevent the appearance of an attack within a few hours. The active substance - nitroglycerin - begins to gradually enter the bloodstream, thus these drugs are much longer than their original "colleague" by the duration of the action.

Along with such an advantage, they are still inferior in speed of action, and this is very important at the time of the attack. This is due to the fact that they are not placed under the tongue, and are washed down with water, respectively, it takes a certain amount of time for the medicine to dissolve and be absorbed into the blood.

Therefore, if the attack has overtaken you suddenly, you can not do without the usual "Nitroglycerin" in the form of sublingual tablets.

Side effects

Any drug can always find side effects. They are indicated in the annotation to the medicine. This, of course, does not mean that this or that effect will manifest itself in you, but it is necessary to know about them.

The side effect of "Nitroglycerin" can be explained by the fact that it dilates the blood vessels. The following frequently occurring undesirable manifestations can be named:

1. Redness of the face and a feeling of heat.
2. Headache, because the cerebral vessels sharply expand and pulsate, which sometimes provokes strong pain.
3. Falling blood pressure.
4. Noise in ears.
5. With a severe overdose, there may be a collapse, even to fainting.
6. Nausea and vomiting, maybe even upset of the stool.
7. Dermatitis.

Prolonged forms of this drug can cause the same side effects. It is worth noting that when they are taken for a long time, habituation begins to develop, so the side effect of Nitroglycerin and its forms is significantly reduced or completely disappears.

Frequency of drug intake

Those patients who suffer from heart attacks often try to endure the pain and do not take "Nitroglycerin". But this does not help in this situation. If the attack does not stop, the pain can increase, then it will be much more difficult to eliminate it.

In severe situations, some patients during the day can take more than 50 tablets. Doctors consider this dose in certain situations quite reasonable.

Most scientists who are researching this drug believe that its continued use can lead to the opposite effect - increasing the frequency of seizures and their strength.

Therefore, the question about whether it is possible to take "Nitroglycerin", the answer suggests only positive, but still it is not necessary to do this without the recommendation of a doctor and in large doses.

Contraindications for admission

Each drug always has its own list of contraindications, so do not rush to go to a pharmacy and buy medicine without a doctor's prescription.

"Nitroglycerin" in any form is categorically contraindicated in the following diseases:

• Low pressure.
• Anemia.
• Acute myocardial infarction.
• Problems with blood circulation.
• Pulmonary edema.
• Glaucoma.
• Alcoholic intoxication.
• Stroke.
• Heart defects.
• Pregnancy.
• Problems with the thyroid gland.
• Renal and hepatic insufficiency.

Do not take "Nitroglycerin" in the event that you are treated with the drug "Sildenafil".

If you have heart attacks, and if you have an anamnesis, the intake of "Nitroglycerin" is contraindicated, then it is advisable to discuss with your doctor what preparations you can take in this case.

Poorly tolerated "Nitroglycerin"

Some after taking the medication feel a sharp headache, dizziness and begin to believe that they just do not fit this drug. But this is due to its vasodilating action. At repeated reception of such can and not occur, or these signs will be shown more softly.

If at each reception you feel bad, experiencing severe pain in your head, then it is worth discussing with the doctor the appropriateness of using this tool.

With frequent angina attacks, this drug alone can save you at a critical time, so do not immediately abandon it at the first manifestations of side effects. Try to lower the dosage and discuss the situation with your doctor.

Storage conditions

After buying any medicine, it must not only be taken in accordance with the instructions or recommendations of the doctor, but also stored under certain conditions. "Nitroglycerin" can not be left in the light. Under its action, it quickly begins to break down, the same happens in a warm place.

To prevent this, the medicine must be stored in the refrigerator. If you have a doctor prescribed "Nitroglycerin" (a recipe in Latin), you will have enough of the instruction that is attached to it. There you can read about all the requirements for storage.

In the manual, you can see an item that recommends storing "Nitroglycerin" in the package in which it was sold. This can be explained by the fact that the vial and cotton wool are treated with a special composition that promotes the preservation of the properties of the preparation.

After you have uncorked the package, "Nitroglycerin" and under all the conditions of storage can not maintain its medicinal qualities for a long time. After a couple of months its effectiveness will drop by 30%. In this respect, capsules are more stable.

If you use this medication quite often, then pills will be fine, and if it is rare, it is better to buy a spray that has a long shelf life.

If you do not want to take a whole vial or a packing of tablets with you on the road, and you decide to wrap a few pieces in a napkin and put it in your purse, you can not even try, after such transportation the drug will not help you.

Tips and advice on the admission

Despite the fact that most of us know what "Nitroglycerin" is, from which it helps, it does not hurt to remind once again the peculiarities of its use:

1. Do not be afraid of a sharp headache after taking the drug, it indicates that the medicine started its work. After a few tricks, these feelings will stop bothering you.
2. If you suffer from angina pectoris, then "Nitroglycerin" should always be at your fingertips.
3. In heart attacks, it is advisable not to use capsules, they contain an oily solution that is absorbed longer.
4. If you take the medicine for a long time, then the effect of it drastically decreases, so you need to take a break.
5. In the presence of eye diseases, take "Nitroglycerin" with extreme caution.
6. At a lowered pressure, taking this medicine is better to postpone, otherwise it may fall even more, and the person will lose consciousness.

In the miraculous influence of "Nitroglycerin" no one doubts, it's not for nothing that more than 100 years, scientists have not been able to invent a more effective drug for angina pectoris. But in spite of all this, the reception is necessary strictly on the recommendation of the doctor with observance of all dosages, so as not to cause harm to one's health.