"Mesipol": instruction manual, reviews, analogs

What is Mesipol? Instructions on the use of this tool, its contraindications and testimony will be discussed in this article. Also, you will find out whether this medication has side effects, what will happen in case of an overdose, in what form it goes on sale and what substances it contains.

Forms of the preparation and its composition

The drug "Mesipol" goes on sale in two different forms: tablets and solution for intramuscular injection. The principle of their action is the same. When oral administration is not possible, injections are used.

The Mesipol solution has such an active element as meloxicam. It also contains the following auxiliary components: glycofurol, meglumine, sodium chloride, poloxamer 188, sodium hydroxide, glycine and water for injection.

The solution has a yellow or greenish-yellow color. It is transparent. It also has a characteristic odor. In a carton box there are 3 ampoules (1.5 ml).

By the way, in addition to tablets and solutions for intramuscular injection, pharmaceutical companies began to produce "Mesipol" suppositories and suspensions, which are intended for oral administration.

Pharmacological characteristics of the drug

Medication "Mesipol" is a non-steroidal anti-inflammatory drug. The drug is able to have an analgesic and antipyretic effect. The anti-inflammatory effect of this agent is associated with a slowing down of the enzyme activity of cyclooxygenase-2, which participates in the biosynthesis of prostaglandins in the inflamed area.

The least active element meloxicam affects cyclooxygenase-1, which takes a direct part in the synthesis of prostaglandin, which protects the mucosa of the digestive tract and affects the regulation of blood flow in the kidneys.

Pharmacokinetics of the drug

The drug "Mesipol" (injections and pills) is absorbed completely. Bioavailability of the drug is 100%. After intramuscular injection (about 15 mg meloxicam), maximum absorption is achieved after 65 minutes.

The preparation we are considering binds to plasma proteins, including albumin (99%). It easily passes through the gistogematicheskie barriers, as well as penetrates into the fluid synovial. The concentration in it is 50% of the concentration of the drug in the plasma.

The active substance of the drug is almost completely metabolized in the liver. At the same time, four inactive pharmacological metabolites are formed.

After application, the medication is equally excreted by the intestines and kidneys (in the form of metabolites). The average half-life of the active substance is 20 hours.

Indications for use of medicament

In what cases is the "Mesipol" appointed? The instruction for use states that most often NSAIDs are recommended for use in the symptomatic treatment of diseases such as:

• Osteoarthritis;
• Arthritis rheumatoid;
• Spondylitis ankylosing (or Bechterew's disease).

Among other things, the drug "Mesipol" (injections and pills) is often prescribed for other degenerative and inflammatory diseases of the joints, which are accompanied by a strong pain syndrome.

Contraindications to the use of non-steroidal agents

In what cases is it impossible to use the medication "Mesipol"? Instruction for use contains a huge list of contraindications. They include the following:

• Hypersensitivity to the active ingredient of the drug or its auxiliaries;
• Incomplete or complete combination of bronchial asthma, acid intolerance to acetylsalicylic, polyposis (recurrent) of the paranasal sinuses and nasal cavity, as well as other NSAIDs, including in the anamnesis;
• Children's age (up to 16-18 years);

• Ulcerative or erosive lesions of the mucosa of the 12-типерстной gut or stomach;
• The period of breastfeeding;
• Bleeding cerebrovascular or bleeding of another origin;
• Active bleeding in the intestine or stomach;
• Period of gestation (pregnancy);
• Intestinal inflammatory diseases (eg, Crohn's disease or ulcerative colitis);
• Kidney disease progressing, including hyperkalemia (confirmed);
• Period after coronary artery bypass grafting;
• Renal failure (severe) in people who have not undergone dialysis (CC less than 30 mL / min);
• Heart failure decompensated;
• Active progression of liver disease or liver failure (pronounced).

Use with extreme caution!

Now you know in what cases you can use the drug "Mesipol" (pills, injections), and in which it is contraindicated. However, there are also situations when the medication we are considering should be administered with extreme caution. Let's consider the list of such cases:

• Elderly age (from 60 years);
• Heart disease ischemic;
• Chronic heart failure;
• Cerebrovascular diseases;
• diabetes;
• Dyslipidemia or hyperlipidemia;
• Diseases of peripheral arteries;
• Creatinine clearance less than 60 ml / min;
• Smoking;
• Ulcerative lesions of the digestive organs in the anamnesis;
• Long-term use of nonsteroidal drugs, as well as their uncontrolled use in large doses;
• The presence of an infection called Helicobacter pylori;
• Regular use of alcoholic beverages (even with low alcohol content);
• One-time intake of oral glucocorticosteroids, including the drug "Prednisolone";
• Severe somatic abnormalities;
• Simultaneous administration of anticoagulants (for example, the drug "Warfarin"), antiplatelet agents (eg, acetylsalicylic acid and "Klopidogrel" medication), as well as inhibitors (selective) reuptake of serotonin (including preparations "Tsitmedialopram", "Fluoxetine", "Paroxetine" And "Sertralin").

Non-steroidal anti-inflammatory drug "Mesipol": instructions for use

Intramuscular introduction of the drug we are considering is indicated only during the first 3 days of treatment. In the future, therapy is continued with the use of oral forms of medicine, that is, tablets.

The recommended dosage of this drug is 7.5 mg or 15 mg once a day. This or that volume of the drug depends on the intensity of the pain syndrome, as well as the severity of the inflammatory process. The medication is administered via a deep intramuscular injection.

Is it possible to combine the drug "Mesipol" (injections) with other drugs? The instruction of this medication states that the contents of the ampoules must in no case be mixed in one syringe with other solutions. This is due to the fact that there is a high probability of incompatibility of the active substance meloxicam with other medicinal elements.

It should be particularly noted that in patients who have an increased risk of adverse reactions, as well as with renal insufficiency (severe) on hemodialysis, the dosage of the nonsteroid drug should not be above 7.5 mg per day.

It is also necessary to remember that the medication "Mesipol", analogues of which we will consider below, in no case can not be administered intravenously.

The maximum daily dosage of the active ingredient meloxicam should be 15 mg. This same amount of medication should be followed and combined use of tablets, suspension for oral administration, suppositories and intramuscular injections.

Cases of overdose

Have you ever experienced an overdose of Mesipol? The injections (reviews about them will be presented at the very end of the article), tablets, suppositories and suspensions can cause bad health of a person if they are used uncontrolled and in large volumes.

Symptoms of overdose may include the following conditions: nausea, impaired consciousness, pain in the epigastric region, acute renal failure, vomiting, bleeding in the stomach or intestines, hepatic insufficiency, asystole, and respiratory arrest.

What to do in case of an overdose? Experts recommend washing the stomach, as well as conduct symptomatic therapy.

By the way, during clinical trials it was proved that colestramine promotes accelerated excretion of meloxicam. Hemodialysis with an overdose is ineffective, since there is a high connection with blood proteins.

Adverse events

Can the drug "Mesipol" (injections) cause side effects? Instructions for the use of this non-steroidal drug state that it can cause a large number of negative consequences. Let's consider them in more detail:

• Alimentary tract: dyspepsia, diarrhea, nausea, perforation of the gastrointestinal tract, abdominal pain, vomiting, flatulence, constipation, transient increase in the activity of transaminases (hepatic), belching, hyperbilirubinemia, ulcerative or erosive lesions of the digestive system, esophagitis, stomatitis, obvious or latent bleeding From the intestine, colitis, gastritis and hepatitis.
• Skin covers: urticaria, itching, bullous eruptions, skin rashes, photosensitivity, Stevens-Johnson syndrome, erythema multiforme, epidermal toxic necrolysis.
• The system of hematopoiesis: anemia, thrombocytopenia, a change in the blood formula and leukopenia.
• Allergy: angioedema and anaphylactic reactions.
• Nervous system: vertigo, dizziness, confusion, headache, emotional lability, tinnitus, disorientation and drowsiness.
• Respiratory system: bronchospasm.
• Cardiovascular system: flushes of blood to the skin of the face, peripheral edema, palpitation and increased blood pressure.
• Organs of vision: blurred vision or blurred vision, conjunctivitis.
• Urinary system: acute renal failure, hypercreatininaemia or increased urea blood, interstitial nephritis, hematuria and albuminuria.
• Local reactions: pain and burning in the place of intramuscular injection.

Interaction with other drugs

• With a single use with other non-steroidal agents and with acetylsalicylic acid, the risk of ulcerative and erosive lesions of the digestive tract, as well as bleeding in them, increases.
• With the simultaneous use of medication with antihypertensive drugs, there is a possibility of a decrease in the effectiveness of the latter.
• Simultaneous reception of Mesipol with lithium preparations promotes the development of cumulation of the latter and an increase in its toxic effect.
• With a single use with the drug "Methotrexate", its side effect on the hematopoietic system is enhanced.
• The simultaneous use of the drug "Mesipol" with diuretics causes the risk of renal failure.
• One-time use with cyclosporine increases the nephrotoxic effect of the active substance meloxicam.
• With simultaneous use with intrauterine contraceptives, the effectiveness of the latter decreases.
• At a one-time use with anticoagulants and thrombolytic agents, the risk of bleeding increases.
• Simultaneous use of the non-steroidal preparation "Mesipol" with colestyramine increases its excretion through the gastrointestinal tract. This is due to the binding of meloxicam.
• A single-dose medication with inhibitors (selective) re-uptake of serotonin significantly increases the risk of bleeding from the digestive tract.
• Myelotoxic drugs increase the manifestation of hematotoxicity of the active substance to meloxicam.

Special instructions for use of the medicine

• The drug "Mesipol" should be used with extreme caution in patients with ulcerative bowel and stomach disease, as well as people who are on anticoagulant therapy.
• During treatment with this medication, it is necessary to monitor the performance of the kidneys, especially in the elderly and patients with chronic heart failure.
• Patients taking both diuretics and Mesipol should drink a lot of fluids.
• If during the therapy the patient has an allergy, the medication should be stopped.

Analogues and the price of a medicinal product

How much is the drug we are considering? In the pharmacy, the injection form of the medicine can be purchased for 400 Russian rubles. As for tablets, suspensions and candles, their price is slightly lower.

What should I do if you could not get Mesipol? Analogs of this drug are sold in almost all pharmacies. Among them are the following drugs: Amelotex, Exen-Sanovel, Arthrosan, Mataren, M-Kam, Libermum, Medsikam, Melbek, Meloks, Bi- "Meloksam", "Meloksam", "Meloflam", "Mixol-Od", "Mirlox", "Movalis", "Movasin", "Movix", "Lem", "Oksikamox" and so on.

"Mesipol": reviews about the drug

Now you know what the drug we are considering is. It's time to find out what the patients are saying about the Mesipol preparation. Reviews about this anti-inflammatory nonsteroidal drug are mixed. On the one hand, patients claim that it alleviates the pain syndromes that are inherent in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and other degenerative and inflammatory joint diseases. On the other hand, patients very often complain that this drug causes quite a large number of side effects, as a result of which they had to stop taking it.

In general, the medicine "Mesipol" that we are considering is completely coping with its task.