Instructions for use "Mannitol". Description of the drug, analogues, reviews

Diuretics have different structures, but have one common property. They increase the volume of excreted fluid from the body. Otherwise they are called osmotic diuretics. These medications are used in the complex therapy of hypertension, pathologies of the cardiovascular system. In addition, their use is justified in any other disorders, accompanied by edema of organs and tissues. Among all osmotic diuretics, Mannitol is the most popular. It is about him that will be discussed in this article.

"Mannitol" - what is it?

"Mannitol" is a medicinal product with a pronounced diuretic effect. Also, the composition significantly increases the amount of blood circulating in the body. The main indications for its use are epileptic status, high intracranial pressure, renal failure.

In the role of the active component of the drug is the same substance - mannitol. Among the auxiliary ingredients, the instruction notes sodium chloride, sodium sulfacil, flavacridine hydrochloride. Pharmaceutical companies produce medication in the form of a solution for intravenous injections. It goes on sale in glass bottles of different volume.

Pharmacological properties

Instructions for use "Mannitol" characterizes as a drug with a diuretic effect. The diuretic effect is due to an increase in the osmotic pressure of the plasma and a decrease in the reabsorption of water. The use of the drug for therapeutic purposes facilitates the passage of fluid from the tissues into the vessels. This is the result expected by patients with high blood pressure in these organs.

The diuretic effect is dose-dependent. The increase in the volume of the drug directly affects the amount of osmotically free liquid, chlorine and sodium withdrawn. When azotemia in patients with cirrhosis of the liver or ascites, the use of medication is impractical. Its use can provoke hyponatremia, therefore independent treatment is unacceptable. During therapy, the doctor must constantly monitor the sodium / potassium content in the blood serum, as well as diuresis and blood pressure.

Indications for use

Instructions for use "Mannitol" recommends the use of the following disorders and diseases:

• Kidney failure;
• An attack of glaucoma;
• Acute hepatic impairment;
• Increased intraocular pressure ;
• Poisoning with chemicals.

Also, the solution of "Mannitol" is used during surgery with extracorporeal circulation, for the prevention of hemoglobinemia.

Mode of application

Diuretic is administered intravenously by drip or jet. Preliminarily it is recommended to heat up to body temperature. The dosage regimen is determined by the doctor taking into account the condition of the patient and his disease. For preventive purposes, the drug is prescribed at the rate of 500 mg per kilogram of weight, in therapeutic - 1.5 g per kilogram of weight. The daily dosage should not exceed 180 g.

In surgical intervention using extracorporeal circulation, the patient is administered 20-40 g of the solution immediately before the operation. Patients with oliguria are first slowly drip the medication for five minutes. The dosage regimen is determined by the doctor. If within three hours after the injection an increase in diuresis to 45 ml / g is not observed, the drug is canceled.

Contraindications and side effects

What does the instruction for use tell us about contraindications? "Mannitol" is not recommended for taking the following pathologies:

• Hemorrhagic stroke;
• Dehydration of the body;
• Failure of the left ventricle;
• pulmonary edema;
• Acute tubular necrosis;
• Subarachnoidal hemorrhage.

With special care, the drug is prescribed for pregnant and lactating women. The use of medication is permissible only under the supervision of a doctor. The specialist must weigh the risk ratio for the baby and benefit for the mother.

Information on side effects

Before the start of therapy, it is necessary to familiarize yourself with the annotation to the drug. What are the side effects of the instructions for use? Mannitol, in case of exceeding the permissible dosage, can cause dehydration of the body. Therefore, the use of a medicine is permissible only under the supervision of a doctor. Dyspepsia, thirst, low blood pressure, convulsions - these symptoms indicate a change in the water-electrolyte balance in the body. The drug should be discontinued and consult a doctor. The specialist should adjust the treatment plan or designate a synonym for the medication.

Available analogues

Considering the description of the drug "Mannitol" (what it is, as well as for the purpose of what it is assigned), it is important to pay attention to its analogues. Despite the good tolerability of the drug, it does not suit everyone. If, during the treatment period, the patient has a headache and vision problems, stop taking it. In especially serious cases, the doctor prescribes a checkup to exclude complications such as subdural bleeding.

Close to the mechanism of action and pharmacological properties of "Mannitol" is lyophilizate for the preparation of infusion solution "Urea". Among other analogues of the drug, "Mannit" earned positive reviews. This drug is used to increase the volume of urine. Pharmaceutical companies release it in the form of a solution for injection. "Mannitol" and "Mannitol" are identical drugs. Their use is justified with increased intracranial pressure, brain edema, glaucoma and other disorders. The only difference is side reactions. The intake of "Mannitol" is sometimes accompanied by a violation of water-electrolyte equilibrium and the appearance of symptoms characteristic of this state. Exceeding the recommended dosage of "Mannit" during treatment can lead to the development of thrombophlebitis and tachycardia. From a medical point of view, "Mannitol" is safer.

Price, testimonials about the medicine

Opinions of consumers about the drug are found with both positive and negative color. An important advantage of a diuretic is its low price. For example, a bottle (200 ml) will have to pay only 100 rubles. The patients' testimonies confirm that the drug fully fulfills the functions assigned to it. Side effects are extremely rare.

Negative reviews are most often due to the use of the drug Mannitol. Tablets for many are the preferred treatment option. This diuretic is made only in the form of a solution for injection. Therefore, patients are forced to abandon it, replacing the analogues.

In conclusion, it should be noted that "Mannitol" is an effective osmotic diuretic. Yet it is a medicinal product. Therefore, before using it, it is necessary to read the instructions. Be healthy!