How much does "Monural" help? Features of application, instructions, contraindications and reviews about the drug

How much does "Monural" help? Few women know the answer to the question. In this regard, in this article, we decided to tell you about what the medicament is used for, how and how much it works, whether it has contraindications and so on.

Packaging, composition, form

About how much "Monural" helps, you can find out from the instructions that are attached to the drug. It is placed in a cardboard box, where laminated multi-layer bags with a drug substance are contained.

The drug under consideration goes on sale in the form of white granules with a mandarin flavor. They are designed to prepare a solution for oral administration.

The answer to the question about how much "Monural" helps is closely related to its composition. The active substance of this drug is phosphomycin trometamol. It also contains additional ingredients in the form of saccharin, tangerine and orange flavoring, as well as sucrose.

Pharmacological characteristics

Many patients who were assigned this drug are interested not only in the question of how much the "Monural" is operating, but also about whether it is an antibacterial agent.

According to the attached instructions, the medicine in question is a modern broad-spectrum antibiotic. It is used in the therapy of a variety of inflammatory diseases of the urinary system.

Before answering the question about how much "Monural" helps, it should be said that it is a derivative of phosphonic acid. This drug is able to have a bactericidal effect, which is due to the suppression of bacterial cell wall synthesis.

Being an analogue of phosphoenolpyruvate, the active substance interacts with the enzyme N-acetyl-glucosamine-3-o-enolpyruvyl transferase. As a result, its irreversible, selective and specific inhibition occurs, which ensures the absence of cross-resistance with other antibiotics, as well as the possibility of synergism with them.

"Monural" is active against many gram-positive bacteria and most gram-negative microorganisms. Its active substance reduces the adhesion of bacteria to the epithelial layer of the urinary tract.

Pharmacokinetics

How much does "Monural" work? The active substance of the preparation is absorbed from the digestive tract almost immediately after administration. At the same time, it quickly accumulates in the urine.

With a single application of the drug solution, its bioavailability is 35-65%. The active substance of the drug does not bind to plasma proteins, but in the human body dissociates into trometamol and phosphomycin and is no longer metabolized.

When taking a single dose of "Monural" in the amount of 3 g, its concentration in the urine reaches a high level (99%) of bactericidal activity against many pathogens of urinary tract infections.

So how many hours does the "Monural" help? According to the enclosed instructions, its maximum concentration is reached in approximately 120-160 minutes. After this period of time, the drug begins its active action.

The medicine is given in unchanged form (about 95%) by means of kidneys. At the same time, its highest concentrations are noted in the urine. Also, 5% of the active substance is excreted together with bile.

The half-life of the antibiotic is four hours.

Pharmacokinetic parameters in special cases

How long will "Monural" help patients with a moderate decrease in renal function? In this category of people, the effect of the drug is also noted after two hours. It is during this period of time that the drug reaches high concentrations in the blood. However, in these patients, the half-life of phosphomycin from the plasma is slightly increased.

How much does Monural help with cystitis? Two days is enough for the patient to develop a persistent therapeutic effect.

Indications for use

As mentioned above, this medication is used to treat various diseases of the urinary system. In particular, this drug helps with:

• Acute attacks of recurrent bacterial cystitis;
• Acute bacterial cystitis;
• Asymptomatic massive bacteriuria in pregnant women;
• Postoperative urinary tract infections;
• Bacterial nonspecific urethritis.

It should also be noted that the solution for oral administration is often used as a prophylactic against urinary tract infections during diagnostic transurethral studies and in surgical intervention.

Contraindications for use

As evidenced by the available information about the product of the pharmaceutical industry we are considering (the drug "Monural"), it is quite effective in cystitis. However, do not forget that any medicine has contraindications. According to the instructions, this drug is not recommended to be prescribed when:

• Severe degree of kidney failure;
• Hypersensitivity to additional and basic substances of the drug;
• And also for the treatment of children under five years of age.

The drug "Monural": how correctly to take?

In cystitis, as well as other diseases of the urinary system, the contents of one sachet must be dissolved in 1/3 cup of plain water. The resulting solution should be taken 2 hours before meals or 120 minutes after. Use of the drug in the process of eating is not recommended, since this will noticeably slow down its absorption in the body.

According to the instructions, it is desirable to take the drug at night. This should be done after the bladder is empty.

One packet of medication is sufficient for one course of treatment. It should be noted that it is forbidden to combine "Monural" with a drug such as "Metoclopramide." This is due to the fact that a combination of these drugs can significantly reduce the concentration of phosphomycin in the blood and urine. As a result of the effect of therapy, you will not achieve it.

People who suffer from diabetes, it is necessary to take into account that the composition of the drug "Monural" is sucrose. Also it should be noted that during its reception it is forbidden to drink any alcoholic beverages.

Dosage of the drug for adults

"Monural" with cystitis (contraindications and use of the drug were described above), as well as in other diseases, adults should be taken in a dosage equal to 3 g (once a day). The solution is used once.

If necessary, the attending physician may prescribe to his patient a second dose, but only after a day.

Typically, such therapy is required for a recurrent bacterial infection, a severe course of the disease (for example, if there is no proper result after a single dose), as well as in old age.

To prevent various infections of the urinary tract with urological intervention or diagnosis, this medication is also prescribed twice. The solution is taken three hours before the planned manipulation or any medical research. The interval after the first intake should be 24 hours.

People with renal insufficiency should be prescribed the preparation "Monural" with extreme caution. Such patients need to increase the time interval between doses of the drug or reduce the dose.

Can I give it to children?

This medicine can be given to children, but only to those who have reached the age of 5. To children it is recommended to take the drug only once in an amount of 2 g. To the child up to the specified age "Monural" is not appointed because of the unformed renal-pelvis system (that is, the kid has not yet developed a filtration system in the kidneys).

Pregnancy and breastfeeding

During pregnancy, representatives of the weaker sex are often concerned about cystitis. The solution "Monural" effectively treats this disease and thus does not cause pathologies in the fetus.

The biggest advantage of this drug is its single dose, while most antibiotics are required to take at least 5-7 days. It should also be noted that this medicine has virtually no side effects and contraindications. As a rule, it is well tolerated by patients. However, only an experienced doctor can prescribe this remedy to pregnant women after a thorough examination. After all, many experts know that the active substance "Monural" easily overcomes the placental barrier. Therefore, in the first trimester of pregnancy, its reception is highly undesirable.

As for lactation, during this period the drug in question is not allowed to be used at all. When acute need for it, breastfeeding should be discontinued, as phosphomycin enters the milk.

"Monural" with cystitis: effectiveness and reviews of the drug

The drug "Monural" for the treatment of cystitis fits best. Specialists have been shown that this medication is effective against many bacteria that cause this disease.

In addition, that the agent has bactericidal properties, it still significantly reduces the ability of microorganisms to become attached to the walls of the bladder.

Therapy of acute cystitis should be started immediately. This is necessary in order to prevent the transition of the disease into a chronic form.

As for the exacerbation of chronic cystitis, it is necessary to take an antibiotic on the first day. The solution is used once in the dose indicated above.

There are many reviews of such a preparation as "Monural". Most patients leave extremely positive comments about it, although occasionally negative feedback can also be found.

So, according to reviews, the positive side of this drug is its high efficiency - the result is observed after a single intake of the solution. In this case, it almost never causes any side effects.

The process of treatment by this means many patients call convenient, and its cost is quite acceptable.

In negative responses, it is reported that this medication is ineffective. But the patients do not say at what indications and when the "Monural" was taken, whether its dosage was respected, whether the doctor appointed him or the patient was engaged in self-medication.