"Fenilin": instructions for use, analogues, reviews

What do they say about such a preparation as "Fenilin"? Reviews of doctors and patients will be considered at the very end of the article. Also we will tell you about the purpose for which this remedy is prescribed, how to correctly take it, whether it has side effects, analogues and contraindications.

Composition and form

In what form is the medicine "Fenilin" made? Instruction for use reports that this drug is available in tablets, the active ingredient of which is fenindion. As auxiliary components use milk sugar, starch, citric acid and talc.

Pharmacodynamics

What are the pharmacological features of the drug "Fenilin"? Instructions for use say that this drug has a direct effect on blood coagulability. It is an anticoagulant of indirect action.

The medication intake promotes the appearance of hypoprothrombinemia, which is caused by the violation of the formation of prothrombin in the liver. Also, this agent significantly reduces the formation of factors 7, 9 and 10. Moreover, it has a large cumulative effect in comparison with neodicoumarin.

After oral administration of the tablets, the concentration of clotting factors decreases within 8-10 hours. The maximum effect of the drug is observed after 25-30 hours.

Pharmacokinetics

Is the drug "Fenilin" absorbed into the systemic bloodstream? Experts say that this drug is characterized by a full and fairly rapid absorption. Its active ingredient penetrates through the histohematic barriers and accumulates in the tissues.

The drug is metabolized in the liver, and is excreted by the kidneys (in the form of metabolites and unchanged).

Indications for use

What is the purpose of the Fenilin tablets? Experts say that this drug is used for both treatment and prevention. The main indications for admission are thromboses, thrombophlebitis, thromboembolic complications caused by embolic stroke and myocardial infarction, as well as similar disorders.

In addition, this medication is often prescribed to prevent thrombosis after surgery.

Contraindications for use

Under what conditions is the patient forbidden to take the drug "Fenilin"? Instruction for use reports the following contraindications:

• Disorders in the work of the kidneys and liver;
• Initial level of prothrombin up to 70%;
• Increased vascular permeability;
• Hemorrhagic diathesis and other diseases associated with reduced blood clotting;
• Ulcerative diseases of the digestive tract;
• Malignant neoplasms;
• Pericarditis.

One can not help saying that the medicine in question is not recommended for use at the very beginning of pregnancy, for several days after delivery and during menstruation.

The preparation "Fenilin": instructions for use

The medicament in question is used only for oral administration. Its therapeutic regimen has certain peculiarities, in connection with this, it is necessary to use this medicine only for the doctor's prescription.

The initial daily dose of the drug is usually 0.11-0.17 g (4-time intake). The next day the amount of the drug is reduced to 0.08-0.14 g, and then to 0.02-0.05 g. After that, the dosage of tablets depends on the level of prothrombin in the blood.

The maximum amount of the drug at one time should be 0.05 g, and the daily amount - about 0.2 g.

To prevent thromboembolic complications, it is necessary to take 0,03 g of a drug per day, dividing this dose by two times.

Therapy of acute thrombosis requires additional administration of heparin. This requires strict monitoring by the doctor, as well as mandatory systematic study of the amount of prothrombin in the blood and other factors of its coagulability.

Treatment with the drug "Fenilin", analogues of which we will list below, are phased out gradually.

Side effects

Does the drug "Fenilin" cause side effects? The way of application and dosage of this medicine should be strictly observed. This is due primarily to the fact that during therapy, the patient may experience various allergic reactions in the form of diarrhea, nausea and hepatitis. Also, according to reviews of doctors and patients, in rare cases, headaches, fever, changes in color of urine and skin, problems with hematopoiesis are observed.

Signs of an overdose

Overdose in patients may exacerbate symptoms that are related to side effects. As a treatment for such conditions, it is necessary to cancel the drug, as well as immediate intramuscular injection of "Vikasol", administration of routine, or vitamin P, calcium chloride, ascorbic acid and general symptomatic therapy.

Drug interaction of the drug "Fenilin"

What is the purpose of this remedy, we described above. Let's pass to the additional information.

When the drug under consideration is combined with "Heparin", salicylates, "Ci-methidine" and sulfonamides, their anticoagulant effect may be enhanced. At the same time, anabolics, "Allopurinol", "Azathioprine", narcotic analgesics, "Amiodarone", tricyclic antidepressants, antibiotics, glucocorticosteroids, androgens, "Diazoxide", "Dizopiramid", "Izoniazid", " Butadion, Metronidazole, Clofib-rat, Alfa-tocopherol, Reserpine, Quinidine, Paracetamol, Disulfiram, Cyclophosphane, and thyroid hormones.

The vitamin K, propranolol, ascorbic acid, urine alkaline, rifampicin, antacids, phenazone, haloperidol, barbiturates, oral contraceptives, diuretics, Meprothan, carbamazepine and " Kolestyramin. "

Special Recommendations

With special care this drug is prescribed for elderly patients, as well as for people with pulmonary embolism, hepatic and renal insufficiency, erosive and ulcerative diseases of the digestive tract, in the postpartum period and with pericarditis.

Treatment of "Fenilin" should be done under the special control of a doctor with mandatory systematic blood testing for the amount of prothrombin and other clotting factors. Also, general urine tests are performed to detect early hematuria.

At some patients on a background of reception of a preparation color of urine in pink color, and palms - in orange can be observed. This is due to the metabolism of fenindione.

The drug "Phenylin": analogues and cost

The main analogues of the drug under consideration are such drugs as Warfapex, Marevan, Neodicumarin, and others.

You can buy a medicine "Fenilin" in the amount of 20 tablets for 120-140 rubles.

Reviews about the drug

Is the medicine "Fenilin" effective? The patients' comments on this drug are very diverse. According to their reports, this remedy is one of the most effective drugs that help improve the blood condition.

Thanks to therapy, blood coagulation rates in many patients come back to normal. It should also be noted that, literally a week after starting treatment, the patient's general condition is improving. In this case, the numbness of the legs disappears, the person stops worrying with convulsions.

As practice shows, in some patients against the background of taking "Fenilin" tablets, bleeding from the nose becomes frequent. However, according to doctors, such changes are the norm. After the course of therapy, everything is normalized.

In addition to discussing the effectiveness of the drug, one can also find stories from patients that this drug is often falsified. Therefore at its purchase always there is a risk to get a false medication. In order to avoid such an incident, you should buy medicines only in well-tried pharmacies that have good recommendations.