Eye drops "Nevanak": reviews and instructions for use, analogues

What are the eye drops for Nevanak? Contraindications to the use of this tool, its instructions for use, side effects and indications will be discussed in the materials of this article. In addition, we will tell you about how much this drug costs, what composition it has and what specialists think of it.

Composition of the drug, its form of release and packaging

Eye drops "Nevanak" go on sale as a 0.1% suspension, which can have either a light yellow or light orange color.

1 ml of this drug contains 1 mg of napafenac. As for the excipients, the preparation includes the following components: a 50% solution of benzalkonium chloride, sodium hydroxide, tyloxapol, mannitol, carbomer, disodium edetate, sodium chloride and purified water.

Eye drops "Nevanak" can be bought in a bottle-dropper made of low-density polyethylene. As a rule, such a medicine is placed in a cardboard box.

Pharmacological characteristics of the drug

Drops "Nevanak" for the eyes are an active form of a non-steroidal anti-inflammatory drug with analgesic and anti-inflammatory action.

After topical application, the active element of the medication penetrates the cornea of the visual organ. There, with the help of hydrolases, its transformation into amphenac occurs. This element inhibits the action of cyclooxygenase, that is, the enzyme that is necessary for the production of prostaglandins.

During the use of this medication, the edema of the eye tissues is noticeably reduced, and all pain syndromes disappear. It should be noted that this drug has no particular effect on blood pressure (intraocular).

Pharmacokinetics of the drug

How long is the drug "Nevanak" (eye drops) absorbed? The responses of specialists say that this medication is absorbed rather quickly through the cornea of the visual organ.

With a daily three-fold instillation of the drug after 2 hours in the blood plasma, low concentrations of the active substance are detected.

With topical application of the drug under the influence of intraocular hydrolases, the active element undergoes immediate hydrolysis to amfenac. After that, its metabolism proceeds through hydroxylation of the aromatic ring. Subsequently, this leads to the appearance of conjugates with glucuronic acid.

One can not help saying that the eye drops "Nevanak", to be more precise, their active substance, are excreted only through the kidneys. However, the concentrations of amfenac and napafenac in urine are not quantifiable.

The drug "Nevanak" (eye drops): instructions for use

The agent we are considering should only be used topically. Before use, the dropper is shaken vigorously. Then it is opened and one drop drips into the conjunctival sac. Do this three times a day.

As a rule, treatment with this drug begins exactly the day before the surgical intervention, which should be carried out for the cataracts. In addition, the therapy is continued for the first two weeks of the postoperative period, including the day of the operation itself. By the way, for 60-120 minutes before surgery, it is recommended to drip an additional drop of medical product.

Indications for the use of drops

What is the purpose of the Nevanak drops? With farsightedness and shortsightedness, they are prescribed only if the patient has inflammatory conditions that have appeared against the background of surgical interventions for the removal of cataracts. Also, this drug is used to prevent and treat postoperative pain syndromes.

Contraindications to the use of drops

In what cases can not I use eye drops "Nevanak"? Analogues of this drug and the drug itself have the following contraindications:

• Age of the patient under 18 years of age (efficacy and safety of the drug in children have not been studied);
• Acute rhinitis, urticaria and bronchial asthma caused by the intake of NSAIDs or acetylsalicylic acid;
• High sensitivity to the elements of the drug and to other NSAIDs.

An overdose of a drug

To date, cases of drug overdose "Nevanak" have not been identified. In case of contact with eyes in excess, the preparation should be rinsed with warm water.

Side effects

What are the side effects of eye drops "Nevanak"? According to the instruction that is attached to this drug, this medication has a rather large number of negative effects. Therefore, before using it, the patient should always consult a doctor.

So what are the side effects of Nevan eye drops? Analogues and the self-presented remedy sometimes cause the following reactions:

• Local reactions . In some cases, patients who use this medication have pain and itching in the eye, as well as pinpoint keratitis, dry conjunctiva, blurred vision, crust formation on the edges of the eyelids, and foreign body sensation. It can also contribute to the appearance of iritis, keratitis, corneal deposits, discharge from the eyes, choroidal effusion, photophobia, eye irritations, allergic conjunctivitis, eyelid disorders, discomfort in the eyes, increased tear and congestion hyperemia.
• Systemic side effects . Sometimes patients who use this drug have headaches, and blood pressure rises, nausea, sinusitis, vomiting, dry mouth, hypersensitivity and stretchiness of the skin (i.e., dermatochalasis).

What other side effects can the drug "Nevanak" (eye drops) cause? Experts say that such medication sometimes becomes the cause of ulcerative keratitis, a defect or epithelial disease of the cornea, damage to the cornea, the formation of an inflammatory infiltrate that occurs on the anterior chamber of the eye. In addition, this agent can worsen the healing process of the cornea, reduce visual acuity and contribute to the opacity of the cornea.

What to do in case of side effects?

If after applying the eye drops we are considering, you experience side effects, then it is recommended to immediately stop using the drug. In addition, the drug should never be used in patients who have signs of corneal damage.

One can not help saying that the experience of using local non-steroidal anti-inflammatory drugs suggests that patients with complications after ophthalmic surgery, corneal epithelial defects, corneal denervation, diabetes mellitus, rheumatoid arthritis, as well as superficial eye diseases or repeated surgical operations that were Spent for a short period of time, have an increased risk of side effects from the cornea. By the way, this fact can create a real threat of loss of sight.

Interaction with other drugs

According to the research, with the simultaneous use of eye drops "Nevanak" with other drugs, negative consequences are unlikely.

In addition, there is currently no information on the simultaneous use of the drug and prostaglandin analogues in question. But, given the mechanisms of action of these drugs, their one-stage application is highly undesirable.

In case of acute need, eye drops "Nevanak" can be used in combination with other preparations (ophthalmic), which are intended for topical application. In this case, the interval between their instillation should be at least five minutes.

The period of breastfeeding and pregnancy

Can I use Nevanak drops during pregnancy (with myopia or farsightedness)? Experts give a specific answer to this question. During pregnancy, this medication is prohibited. Moreover, if drops were prescribed to a young mother during lactation, then breastfeeding should be stopped immediately.

Tests on experimental animals revealed reproductive toxicity of the agent under consideration. With careful study of the effect of the active substance on the reproductive organs of mice, the administration of toxic doses (more than 10 mg / kg) each time led to dystocia, as well as an increase in the number of spontaneous abortions, a decrease in the growth and weight of embryos and a decrease in their survival.

One can not but say that in pregnant rabbits, taking this medication in low-toxic doses (30 mg / kg) all the time led to an increase in malformations of rabbits.

Special instructions on the use of eye drops

Where can I get eye drops "Nevanak"? In Grodno and other Belarusian cities, as well as in our country, this drug is sold in almost every pharmacy.

Those patients who have been prescribed this medicine should avoid prolonged exposure to the sun.

The use of nonsteroidal agents (local) can easily lead to the formation of keratitis. In some susceptible patients, prolonged use of such medications causes thinning of the cornea, rupture of the epithelial cells, as well as erosion of the cornea, perforation and ulceration. Such side effects can contribute to loss of vision. Patients with signs of ruptured epithelial cells should immediately stop using the medication. They also need to be under strict medical supervision.

The use of nonsteroidal drugs (local) in combination with an ophthalmic operation can cause intense bleeding, including hyphema. Therefore, such eye drops should be used with particular caution by those patients who are prone to bleeding. The same is true for patients who take medications that increase blood coagulation time.

The medicine we are considering contains a preservative such as benzalkonium chloride. According to specialists, it can cause eye irritation, as well as discoloration of contact lenses. By the way, wearing the latter is highly not recommended during the postoperative period (after removal of cataracts). Also, contact lenses can not be used during the treatment with Nevanac.

One can not but note the fact that benzalkonium chloride, which is a part of the drug, can cause toxic ulcerative keratitis and spot keratitis in the patient. In this regard, with prolonged and frequent use of the drug requires special medical supervision of the condition of patients.

The use of a local non-steroidal drug may prevent timely detection of signs of acute eye infection, since they do not possess antimicrobial properties. In the case of the development of such a disease, a single application of NSAIDs with antibacterial agents should be carried out in compliance with all precautions.

With the use of nepafenac, there is a possibility of developing cross-sensitivity to phenylacetic acid derivatives, acetylsalicylic acid, and other non-steroidal agents.

During the use of this drug is extremely not recommended to touch the tip of the bottle with a medicine to any surface, in order to avoid its contamination. After use, the bottle should be well closed.

Analogues and cost of medication

How much do eye drops "Nevanak" (Belgium) cost? In pharmacies in Moscow and other cities of our country, this drug in the amount of 5 ml can be purchased for 500-600 Russian rubles. If for any reason you could not find this medication, then it should be replaced with an analog. As such a drug may act eye drops "Nepafenac."

Drops "Nevanak": opinion of experts and patients' opinions

Most experts hold the opinion that without eye drops "Nevanak" to perform a surgical procedure for the removal of cataracts is unsafe. Therefore, this drug is often prescribed to patients with this diagnosis, especially if an operation is planned in the near future.

As for those people who were prescribed these drops, they do not observe a visible effect from them. Moreover, with long-term use this drug causes a rather large number of side effects. For example, some patients complain of the appearance of haze in the eyes, while others complain of a burning sensation.

According to the instructions, with these side effects, the use of drops should be stopped immediately, which is very distressing to many patients. After all, one bottle of this medicine is quite expensive.

Terms and conditions for storage of medicinal product

Keep eye drops "Nevanak" preferably at a temperature of 5-8 degrees in a place inaccessible to small children. Shelf life of this drug is 2 years. Fully apply this tool should be within four weeks after opening the bottle-dropper. After the expiry date indicated on the package, the medicinal product should not be used.