"Diaphlex": instructions for use. Analog "Diaflex"

The non-steroidal anti-inflammatory drug, produced in Romania, is one of the leading medicines used in the treatment of diseases of the musculoskeletal system. It also has a pronounced antirheumatic effect. The medical drug "Diaflex", about which reviews are both positive and negative, is prescribed, in particular, for osteoarthritis. This disease affects the joints, as a result of which the cartilaginous tissue is especially strongly deformed and changes , which leads to painful consequences.

Tablets "Diaphlex" are made in the form of capsules with a dosage of active agent diacerein of 50 mg. In pharmacies, the medicine is dispensed exclusively by prescription, as it has a specific effect on the human body and interacts with other medications.

The price policy of the drug is available to the average statistical population. It is included in the State Register, certified, has parameters that meet the standards, and the official trade name "Diaflex". Analogues, the price of which varies widely, have the same active substances and composition.

Qualitative and quantitative characteristics

Capsule "Diaphlex Rompharm" has a shell of hard gelatin of light brown color, inside of which there is a loose substance. Chemical composition and weight content:

• Iron (III) oxide 2.2 mg;
• Titanium dioxide 750 mcg;
• Gelatin ~ 75 mg.

Active and auxiliary compounds of the preparation:

• Diacerein in an amount of 50 mg;
• Magnesium stearate - 12.5 mg;
• Lactose monohydrate ~ 250 mg.

Pharmacological effects

The drug itself, like the analogue of "Diaflex" - injection solution "Vipraxin" - has anti-hypodermic and anti-inflammatory effect on the human musculoskeletal system.

The basic compound is reduced to an active metabolizing form, which is able to suppress the action of inflammatory mediators, in particular interleukin-1 and -6, tumor necrosis factor-alpha. Influence on the body begins to manifest after taking the drug for 2-4 weeks. When administered orally, "Diaphlex" patients' reviews of which fully confirm the therapeutic effect declared by the manufacturer, an anti-inflammatory and analgesic effect occurs on the foci of the disease.

Chemical kinetics of processes

The drug, as well as the analogue of "Diaflex" - the tablet "Artra Chondroitin" - is relatively quickly absorbed by the gastrointestinal tract, entering the blood. It is recommended to take the medicine along with the main food intake, in this case, the absorption of the substance is significantly increased by about 25%. With a single use of the drug, the maximum concentration of the active substance in the human body is 3.15 mg / l. At constant reception there is an accumulation, hence, the content of diacerein slightly increases. The highest concentration is reached after 144 minutes.

The active substance is completely reduced to rhein, which almost completely binds to proteins. In addition, the drug has the ability to pass through the placental barrier and get from the circulatory system into the central nervous. The half-life of rhein is 255 minutes. From the body, the substance is excreted in the urine in the form of sulfates, glucuranide and slightly unchanged.

Indications for use

The drug is prescribed for osteoarthrosis of primary and secondary. These are diseases that affect joint tissues mainly in women during menopause, as well as in people older than sixty years. In some cases, the drug also has a positive effect in the complex of preparations for osteoporosis.

The strategy for the application of a medical device must necessarily be developed by a doctor. Self-medication is strictly prohibited. It is recommended that you carefully read all the information on the preparation "Diaflex" instructions for use. Analogues can have other side effects, specific effects on the human body and the different efficacy of the active substance in the fight against the disease.

Prohibition to use

Contraindicated treatment with this drug during pregnancy and lactation, as the active substance, overcoming the placental barrier, has a detrimental effect on the fetus and in the composition of maternal milk adversely affects the health and development of the child. All analogues of such a drug are also prohibited for this category of patients. The active substances included in their composition are harmful to the infant organism and may accompany the development of pathologies during the period of fetal formation.

Limitations and contraindications

Analogue "Diaflex" - "Actasulide" - in tablets is not prescribed for the treatment of adolescents under the age of eighteen. It is also not recommended to use the drug in the presence of individual intolerance to some of its components. If you have a syndrome of low absorption of glucose and galactose, as well as lactose deficiency - the drug is strictly contraindicated to you.

The drug should be administered under strict supervision and only according to the prescription of the doctor in the presence of inflammatory processes in the gastrointestinal tract, renal or hepatic insufficiency or intestinal obstruction.

Dosage and treatment period

The reception of the drug "Diaphlex Rhompharm", reviews of which say that during the first two weeks of the drug application acceleration of intestinal motility occurs, it is recommended to start with one capsule per day after the main meal, without destroying the capsule shells and washing with a lot of water. After four weeks, it is necessary to increase the dosage twice - in the morning and in the evening, therefore, a day should take 2 capsules, which makes the total amount of active ingredient 100 mg.

The result of the medication appears on average after a period of two to four weeks. The general course, which includes other analogues of drugs of this spectrum, should be at least four months. Based on the degree of effectiveness of the fight against the disease, the attending physician may prescribe a longer period of admission.

Side effects on the body

When using the drug, the following reactions from the gastrointestinal tract were noted: pain in the abdomen, nausea, vomiting, upset of the stool. Allergic manifestations: urticaria, bronchial spasms, anaphylactic shock, symptoms of fever, mucosal edema. In addition, there may be general malaise, as well as a change in the normal color of urine to brown due to a violation of the acid-base balance. Here is all the information that is given to us about the preparation "Diaphlex" instruction. Analogues of the drug may have similar and other side effects.

Cases of overdose

Data on the excess of the recommended concentrations of the drug were recorded. Patients experienced general deterioration of health, lethargy, indigestion. If you cancel the reception or restore the correct dosage, the symptoms are usually removed. There were no more serious consequences, unlike other preparations for osteoporosis. The drug, even in case of an overdose, does not have a negative effect on the body, which could not be restored.

Interaction with other medical devices

Antacids and any remedy for diarrhea and poisoning, having absorptive properties, significantly reduce the absorption of the drug, as it absorbs it. Any other analogue of "Diaflex", which includes an excellent active substance, may not depend on the reception of such funds. Also, the combination of the drug with a laxative or substances that increase the volume of the stomach, for example, with a dietary supplement that has a lot of fiber in its composition, is contraindicated.

Taking antibiotics, combining treatment with a course of chemotherapy, as well as other manipulations or drugs that disrupt the normal intestinal microflora, can lead to significant problems in the digestive system.

Other tips for use

The duration of admission, the change in the standardized dose and the repetition of the course can be prescribed only by a specialist doctor. The use of analgesic drugs is recommended to cease after the appearance of a pronounced therapeutic effect of diacerein treatment.

The doctor during the reception of the drug "Diaflex Rompharm" is obliged to periodically monitor certain parameters, directing the patient to the delivery of blood, urine and liver tests. It is important that these characteristics are normal, as the results are concluded on the effectiveness of treatment, the necessary dosage, the duration of therapy, the repetition of the course or the replacement of the drug with an analog. When you pass the tests, you need to inform the laboratory assistant about diacerein treatment, since urine has a specific color, and in certain studies, deliberately false conclusions are possible.

For patients with chronic kidney disease, the standardized dose of the active ingredient is half that stated in the instructions. In the further picture of the treatment, it is possible to increase it under the strict control of the doctor.

Reception "Diaflex" does not affect the ability of the patient to drive a car, as well as work with potentially dangerous mechanisms and structures.

Keep the drug recommended at a temperature not exceeding 25 degrees Celsius, in a dry place inaccessible to sunlight and children. Use the medication for the intended use for 3 years.

Reviews about the drug "Diaflex"

The majority of Internet forums devoted to questions of medicine and treatment with these or those preparations, contain set of responses and about a preparation "Diaflex Rompharm". Often patients complain about the duration of the admission and the late effect, as well as the fact that you have to take additional painkillers. Although the instructions to the drug indicate that the drug acts this way.

At times, more can be found positive comments, which are evidence of the effectiveness and effectiveness of the tool in the fight against severe joint disease - osteoarthritis. Users note that, on average, a positive effect appears around the second week of admission, and the results are fixed for a long time. Many go on repeated courses with the drug "Diaflex", as the effectiveness of such treatment is justified by high efficiency.

Price policy of analog series

The cost of "Diaphlex Rompharm" and its analogues ranges from 800 rubles to 2500 thousand per package. The price of the same drug may vary depending on the pharmacy where it is sold. There is no guarantee that a more expensive tool will work better than a budget one. In this case, the individual parameters of the organism and the severity of the disease play a role.