"Clarotadine": instructions for use. Where to buy Clarotadine? From what tablets "Clarotadine"? Analogues of "Clarotadine"

Allergic reactions - a topic quite relevant, especially for parents. After all, every year the number of so-called "allergies" is constantly increasing. Therefore today we will consider in detail the drug "Clarotadine". Instructions for use will begin our review of this drug. We recommend that you read it before using it. You can buy Clarotadine in any pharmacy in your city and without a prescription.

When to apply

This drug can be used for allergic conjunctivitis, edema Quincke, with urticaria (acute chronic, and also idiopathic). The drug "Clarotadine" is also effective in the period of year-round or seasonal rhinitis; At pseudoallergic reactions, which are caused by releasing histamine; Reactions to the bites of various insects; As well as with itching dermatoses. The list can be supplemented.

What is produced

Consider first the drug "Clarotadine" -syrup. Instructions for using it will be given below. Dosage - 5 mg / 5 ml. Loratodina (active ingredient) is one milligram per milliliter of syrup. Excipients: propylene glycol, sugar, benzoic acid, ethyl alcohol, citric acid, tropeoline, purified water, food flavors.

It is released in a bottle of dark glass, whose capacity is one hundred milliliters. This vial is in a cardboard box. The kit also includes a special measuring spoon.

Now consider the tablet "Clarotadine". One tablet contains ten milligrams of loratodine. Of the auxiliary substances - MCC, milk sugar, calcium stearate, glycolate, sodium starch. They are placed in contour squares, each with seven or ten pieces. In cardboard boxes there can be from one to three packages-plates.

Pharmacodynamics

This drug belongs to H1-antihistamine drugs, which do not possess anticholinergic and central action. Begins to work already half an hour after use and is valid for 24 hours. It is important that with prolonged use of this drug does not develop resistance to it. It should be noted that the substance loratodine, as well as its metabolites are not able to penetrate the BBB.

Pharmacokinetics

With regard to absorption, during oral administration at those doses that are recommended by the manufacturer, the main component of loratodine is quickly and fully absorbed into the circulatory system through the gastrointestinal tract. Concentrations, which can already be determined, appear in the blood plasma after fifteen minutes after ingestion. As for the time to reach Cmax in loratodine plasma, it ranges from one hour forty minutes to two hours thirty minutes.

But the time to achieve Cmax of its active metabolite is almost three hours. Just remember that the simultaneous consumption of food along with the drug can slow the achievement of Cmax loratodina, as well as its active metabolite in plasma for one hour. At the same time, Cmax of these substances will be unchanged, and the food is incapable of influencing the result in any way.

Now about the elderly. "Clarotadine" (instructions for use notes), they can take without any special reservations about the age. Just keep in mind that the time to reach Cmax increases by an hour and a half, unlike young people. As for alcoholic liver damage, depending on the severity of the disease, the time to reach Cmax also increases.

In the blood plasma, the content of loratodine with its active metabolite reaches the steady-state level in most patients on the fifth day after administration. And the connection with plasma proteins is 97%.

Metabolism

In the liver, the active substance loratodin is metabolized, forming an active metabolite of descarbotoxyloratadine. This is due to the action of cytochrome P450 isoenzyme CYP3A4. The effect of the cytochrome P450 isoenzyme CYP2D6 also has an effect, although to a lesser extent. The present cectonazole, which is an inhibitor of CYP3A4, allows loratodine to be converted to descarbonethoxyloratadine. This is due to the effects of CYP2D6.

Excretion

The preparation "Klarotadin" (the instruction on application also about it or this mentions) through a kidney, and also together with bile is deduced. The average T1 / 2 of loratadine is eight hours and twenty minutes (the range can range from three to twenty hours). As for the active metabolite, its average value is twenty-eight hours (the range can be from six hours forty minutes to thirty seven hours).

The average rate of descaboethoxyloratadine is seventeen hours and thirty minutes (range from eleven to thirty-eight hours). If it is a case of liver damage by alcohol, then T1 / 2 will increase along with an increase in the severity of the disease. But in patients who have renal insufficiency, and also who undergo hemodialysis, the pharmacokinetics does not change much.

Pregnancy

Pregnant women should not take this drug, because "Clarotadine" to children who are in the womb, can cause harm. If the need arises for the use of this medication by a nursing mother, then it is necessary to suspend breastfeeding until the treatment is completed.

Contraindications

Like other drugs, there are contraindications and "Clarotadine". Instructions for use indicate that this drug can not be used if the patient has a hypersensitivity to any of the components of this drug. Pregnancy and lactation are also circumstances in which this remedy is not prescribed and not accepted. Patients who have hepatic impairment should take the drug Clarotadine with caution.

Side effects

Now we should talk about how this drug can affect the human body. Disorders of the nervous system are possible, namely anxiety, asthenia, hyperkinesia, agitation in the child, drowsiness, tremor, parasthesia, depression and amnesia. Subcutaneous fat, as well as skin can react to the components of the drug with dermatitis.

If we talk about the genitourinary system, then it can change the color of urine, the patient can feel urge to urinate, which will be accompanied by pain. Vaginitis, dysmenorrhea and menorrhagia may also develop.

From the endocrine system is also possible violations. Weight may increase, the patient will feel thirsty, and also he may have sweating. The musculoskeletal system can also undergo some irregularities in its work. This is the spasm of the calf muscle, and myalgia, and arthralgia.

The digestive system can also suffer. Distortion of taste, diarrhea or constipation, anorexia, gastritis, dyspepsia, increased appetite, flatulence and stomatitis - all this with some probability can arise when using Clarotadine.

The respiratory system is also affected. Infringements will be shown in the form of a bronchospasm, a cough, a sinusitis, and also dryness of a mucous membrane in a nose. Also, conjunctivitis may develop, eyesight may be disturbed, pain in the ears and eyes may appear. The cardiovascular system is also susceptible to side effects, which can manifest itself in the form of rapid heart rate, blood pressure increase, as well as its decrease.

There are often cases of allergic reactions, manifested in the form of angioedema, itching, hives and photosensitization. There may also be back pain, fever, dysphonia, chest pain, chills, blepharospasm, and pain in the mammary glands.

As you can see, the side effects can be quite serious, so do not forget about it. Consultation of a doctor is mandatory both before the first intake of the drug, and in case of finding the above mentioned problems.

Application and dosage

Syrup and tablets "Clarotadine" from which - figured out. Now let's talk about how to take it. These medications are intended for internal use. Children who are older than twelve years, as well as adults, the recommended daily dose is ten milligrams. These are two measuring spoons of liquid syrup or one tablet. But for children from two to twelve years, whose body weight is less than thirty kilograms, it is recommended to take five milligrams. This is one measuring spoon or half a tablet. The daily dose should not exceed this figure. If the mass is more than thirty kilograms, the dosage will be the same as for adults.

Overdose

If you do not listen to the recommendations and take the drug in large quantities, you may experience symptoms in adults, which will now be listed. This is tachycardia, headaches and drowsiness. And in children, whose body weight is less than thirty kilograms, with an overdose, there may be an increased heart rate, as well as extrapyramidal symptoms.

If the patient is admitted an overdose, you should immediately contact the doctor. It is also necessary to take measures to ensure that the drug has been removed from the gastrointestinal tract and absorption has been reduced. This is done by inducing vomiting, washing the stomach, and using activated carbon. In case of necessity, symptomatic therapy may be performed. It should be remembered that the active substance loratadine can not be excreted from the body by hemodialysis. There are also no data on excretion of this element during peritoneal dialysis.

Interaction with other drugs

If you apply "Clarotadin" in a therapeutic dose, potentiating effects with alcoholic beverages are not detected. And when using this drug with antibiotics such as "Cimetidine", "Erythromycin" and "Ketoconazole", the concentration in the blood plasma of loratodin will increase. This phenomenon is not clinically apparent, and also has no effect on the electrocardiogram.

There is evidence that inducers of microsomal oxidations, which include ethanol, phenytoin, barbiturates, rifampicin, zixorin, tricyclic antidepressants, phenylbutazone, can reduce the effectiveness of this drug.

special instructions

Patients who suffer from impaired hepatic function and who have renal failure (glomerular filtration has a rate of less than thirty mL / min) the recommended initial dose of Clarotadine should not exceed ten milligrams (one tablet or two measuring syrups) in two Day. You can not also give this drug to children, whose age is less than two years.

Everyone who started taking this medicine should refuse for the entire period of treatment from employment any kinds of potentially dangerous activities that require an increased concentration of attention, as well as the speed of psychomotor reactions.

Analogues

It will be fair to say that the drug "Clarotadine" is not the only one of its kind. There are analogues both among domestic and imported medicines. A fairly common foreign "colleague" is the drug "Claritin". Its properties are almost the same as in the above-mentioned drug "Clarotadine". Price is the main difference. Overseas drug is much more expensive. Domestic has the price, depending on the equipment. So, the package of 7 pcs. Will cost about 100 rubles., Cellular outline packaging 10 x 3 - about 270 rubles. And syrup 100 ml - about 135 rubles.

We will not discuss here on the topic that it is better to use - Clarotadine or Claritin. This is a private matter for everyone, and you must decide for yourself, buy a cheap domestic drug, or give preference to a more expensive foreign one. But it is worth noting that for all these years, the drug "Clarotadine" proved very good. Analogues in this case appear every day.

In any case, before you start taking these drugs and all the more prescribe them to children, be sure to consult your doctor. This will protect you from possible negative consequences that may result from the intolerance of the drug, its misuse or overdose. It should always be remembered that such consequences can pose a significant threat to your health, the health of your children, and your lives.