"Bisoprolol-Prana": indications for use, analogs, reviews, instructions for use. "Bisoprolol-Prana" and "Bisoprolol": the difference

There are many medications based on bisoprolol that are successfully used to treat high blood pressure and heart muscle failure. Among them, the domestic preparation "Bisoprolol-Prana" is distinguished.

Characteristic

This selective beta-blockade agent is produced by the Russian company Pranafarm.

Available in the form of round, biconvex tablets, which have a separation and coating in the form of a film shell.

When using the "Bisoprolol-Prana" tool, the instructions for use are the first thing that you need to pay attention to. The drug is available in the following dosages: 5 and 10 mg. The color of the shell of smaller tablets is light yellow, and large ones - light orange. The contents of the drug is almost white.

Composition

In one tablet of the medicine "Bisoprolol-Prana" as active substance contains 5 and 10 mg of bisoprolol hemifumarate. The presence of magnesium stearate, maize starch, cellulose with a microcrystalline structure, crospovidone, silicon colloidal oxide, calcium dehydrated hydrophosphate allows to form a drug and provide the necessary solubility and bioavailability.

In the film coating of a dosage of 5 mg, iron oxide of yellow color, polyethylene glycol (grade 400), titanium dioxide, silicone is present. In a coating that envelops a large pill, there is another colorant in the form of red iron oxide.

Mechanism of action

To selective beta-blockers, which do not have their own activity of sympathomimetic type, include "Bisoprolol-Prana." Instructions for use describe its pharmacodynamic features. Tablets have the effect of reducing blood pressure, normalizing the rhythm and eliminating the ischemia of the muscles of the myocardium. When the dose of the heart receptor beta-1-adrenoreceptor is blocked by small doses, the production of cyclic adenosine monophosphate and the current of calcium ions inside the cells decrease. There is also a decrease in the reduction of the heart rate and its frequency, inhibiting the processes associated with conductivity and excitability.

Hypotensive effect is manifested when the value determining the minute volume of circulation is underestimated, and the effect on the peripheral vascular channel is reduced. Reduction of high pressure occurs after several days, and for stabilization of action, a two-month treatment is necessary.

Antiarrhythmic effect is manifested when eliminating the causes that violate the heartbeat. These include the state of tachycardia, increased activity of the nervous system in the sympathetic department, increased content of cyclic adenosine monophosphate, hypertension arterial.

Indications for use

Before use it is necessary to study for which groups of patients "Bisoprolol-Prana" is intended. Indications for use are associated with antianginal effects. It is caused by a lower requirement of cardiac myocardium in oxygen molecules due to lowering the frequency of contractions, increasing blood supply and time for diastole.

What is the effect of such a drug as tablets "Bisoprolol-Prana", from which they are taken? Given the pharmacotherapeutic characteristics, they are used for:

• The treatment of arterial hypertension;
• Ischemic heart disease;
• Angina pectoris with tension;
• For prevention of secondary myocardial infarction:
• Insufficiency of chronic type.

Here are the main groups for which the use of the drug "Bisoprolol-Prana" is desirable. Indications for use are associated with impaired cardiac function. This includes sinus rhythm increase, supraventricular and ventricular extrasystole, changes in heart rate when protruding the mitral valve and hyperthyroidism.

Specificity of drug use

Instructions for use "Bisoprolol-Prana" recommends taking the medication in the morning before breakfast, entirely without chewing.

For the therapy of hypertension, cardiac ischemia and prevention of the state of angina pectoris , a single dose of a smaller dose of tablets, including 5 mg of bisoprolol, is used. If necessary, the dosage is doubled, but it is also consumed once. The maximum amount of bisoprolol should not exceed the daily norm of 20 mg.

Only the attending physician can prescribe the dosing and timing of the Bisoprolol-Prana medication. The indications must comply with the drug's instructions. Before appointment check the frequency of contractions of the heart muscle. It is possible to adjust the number of tablets after studying the therapeutic response.

Many patients wonder whether Bisoprolol-Prana can be divided in half. The presence of a separator makes it possible to reduce the tablet if a different dosage is required.

To eliminate heart failure of a chronic type, 1.25 mg of bisoprolol was used the first week. This dose can be obtained by dividing the tablet with an active substance content of 2.5 mg. However, it is necessary to start therapy with a drug of another manufacturer, since the "Bisoprolol-Prana" agent is only available for 5 and 10 mg. During the second week, appoint 2.5 mg. From the 14th day of treatment, 3.75 mg of the drug is taken. In the fourth week, the dosage is increased to 5 mg, and after two months of therapy, 7.5 mg of bisoprolol is used. The twelfth week begins with a dose of 10 mg.

If the patient has various disorders in the work of the kidney or liver, and the values of creatinine clearance less than 20 ml per minute, then the maximum can be prescribed not more than 10 mg of the drug.

During a routine operation, bisoprolol is canceled in two days so that it does not affect anesthesia. If a pill was drunk, then such an agent for anesthesia is selected, which manifests an inotropic effect, negative in the minimum size.

When an elderly patient develops a bradycardia attack with a heart rate of less than 52 beats per minute, hypotension of the arterial hypertension with a systolic pressure less than 100 millimeters of mercury, bronchospasm, ventricular arrhythmia, hepatic and renal function is disrupted, then the dosage is reduced, until the therapy is completely withdrawn. Exclusion of bisoprolol can cause the development of a depressive state, which is caused by this beta-blocker.

Elderly people do not adjust the dosage.

Do not sharply interrupt the treatment, which can cause the development of severe arrhythmia or myocardial infarction. The drug is canceled by a smooth dose reduction for 14 days. For three days, a dosage reduction of 25% is allowed.

Features of treatment

For the use of "Bisoprolol-Prana", the instructions for use include a list of activities that monitor the condition of a sick person. They include the daily early detection of heart rate and pressure measurement, which are then checked after three months. Other important indicators are the electrocardiogram and the sugar level in diabetics, which are measured no more often than after 5 months.

Elderly patients need periodic monitoring of kidney function, which is carried out after 4 months.

Therapy of chronic heart failure at the initial stage of taking a small dose requires a four-hour examination of the patient, which verifies the frequency of myocardial contraction, arterial pressure and an electrocardiogram is made.

Before the appointment of treatment with bisoprolol, the patient is taught how to calculate the heart rate. In the case of low values of this indicator (up to 50 beats per minute), medical consultation is required.

Also, describing the action of the drug "Bisoprolol-Prana", the instruction includes information on the need for studies that determine external respiration for patients with bronchopulmonary diseases.

Not all patients with beta-adrenoblocker drugs help treat angina. Their inefficiency is due to the presence of severe coronary atherosclerosis, which has a low ischemic threshold. In this state, the heart rate will be less than 100 beats per minute, and an increase in the end-diastolic volume in the left ventricle with violation of subendocardial blood flow is observed. Bisoprolol also helps people who are smokers.

People with bronchospastic disorders are prescribed such a cardioselective agent if there is intolerance and low effectiveness of drugs that reduce blood pressure. In overdose, there is a high probability of bronchial spasm.

If you treat patients with thyrotoxicosis beta-adrenoblocker, then it is possible to mask certain clinical signs of excessive thyroid function, primarily tachycardia. Such patients can not be abruptly canceled the drug, in order to avoid the amplification of symptoms.

If patients wear contact lenses, taking bisoprolol can cause a decrease in the production of tear fluid, which requires additional instillation of the eye with special drops.

When the drug is used by patients with pheochromocytoma, then paradoxical arterial hypertension is possible. In this case, a preliminary alpha-adrenoblockade action is necessary.

The presence of diabetes masks the attacks of tachycardia caused by a decrease in the level of glucose in the blood plasma. Being a selective beta-adrenoblocker, the drug is not able to enhance insulin hypoglycemic status and inhibit the normalization of the glucose level to the desired values.

Catecholamines, normetanephrine, antinuclear antibodies and vanillylmandelic acid in blood and urine are determined only when Bisoprolol-Prana is excluded.

For pregnant and lactating women, prescribing is done taking into account the benefits to the maternal organism, but there is a possibility of undesirable consequences in the embryo.

Who is contraindicated in treatment?

Tablets "Bisoprolol-Prana" instructions for use do not recommend use with increased susceptibility, acute or chronic form of decompensated cardiac insufficiency, cardiogenic shock, blockade of sinoauric and atrioventricular second and third type, with a syndrome associated with weakness in the sinus node, slow heartbeat With an intensity of less than 60 beats.

Contraindication is the presence of:

• Cardiomegaly with an increase in the size and mass of the heart muscle;
• Low blood pressure in arteries with a systolic value less than 90 millimeters of mercury;
• Chronic obstructive pulmonary disease;
• Bronchial asthma;
• Disturbances of blood circulation in peripheral vessels in the late stages.

Unwanted consequences

The medicine "Bisoprolol-Prana" can provoke various side effects that affect the central and peripheral zones of the nervous system. They show headache, fatigue, sleep disturbance, depressive condition and hallucinations.

Undesirable processes in the heart and blood vessels are caused by orthostatic hypotension, hot flashes, sweating, slow heart rate and myocardial insufficiency.

Other manifestations of side effects are decreased secretion of the lacrimal gland, development of conjunctivitis, diarrhea, itching on the skin, constipation, nausea, muscle weakness and seizures. Obstructive symptoms may appear in the bronchi.

Similar tools

The original means based on bisoprolol are the tablets "Concor". They are produced by the German company "Merck".

On the basis of this medication, similar preparations were prepared containing, as an active ingredient, the substance of bisoprolol fumarate.

Russian drug manufacturers produce beta-blockers with different trade names. An example is the "Bisoprolol-Prana" remedy: its analogs have a dosage of 2.5 mg, 5 mg and 10 mg. Such medicines include tablets:

• Bisogamma;
• "Niperten";
• "Cordinorm";
• Biprol.

Similar funds are also made by foreign companies. On the pharmaceutical market, there are products with the name of the enterprise in the name, for example, "Bisoprolol-Teva", "Bisoprolol-Ratiofarm", "Bisoprolol-Sandoz", "Bisoprolol-Lugal".

There are analogues, called simply "Bisoprolol". Such medicines are produced by Russian plants: Vertex CJSC, Severnaya Zvezda CJSC, Ozon Pharmaceuticals LLC, Biokom CJSC.

If you compare tablets "Bisoprolol" and "Bisoprolol-Prana", the difference will be in the qualitative and quantitative composition of the auxiliary components. Such discrepancies do not affect the bioavailability and permeability of the active substance in the body, which means that the therapeutic effect of the drug will be the same.

Reviews

Many patients note the convenience of using medicines containing bisoprolol, because they are taken only once a day. One tablet is enough for the whole day to normalize blood pressure.

About the tool "Bisoprolol-Prana" reviews are good. They indicate its high selectivity, which is why taking tablets is accompanied by fewer undesirable consequences compared to other beta-blockers.

Patients note the ease of use and rare side effects that contribute to the transition of some patients to treatment with this drug.

Men say that taking the drug does not cause a violation of potency. In addition, this fact has been proved with the help of numerous studies.

The drug "Bisoprolol-Prana" shows metabolic neutrality with respect to cholesterol, triglyceride and glucose metabolism. This property allows you to prescribe it to patients who have a second type of diabetes mellitus or a predisposition to increase the glucose level in the blood. Accordingly, such patients also leave positive reviews about the drug.

Due to the small number of unwanted reactions, tablets are prescribed to patients in old age. Patients argue that the drug is more effective and safer than other antihypertensive agents of the beta-blocker series.

The advantage of the medicine "Bisoprolol-Prana" is its low price, which is quite affordable for low-income people, which is also reflected in grateful reviews.

But despite all the advantages of tablets, only a doctor can prescribe them on the basis of the results of the examination.