"Amoxil": instructions, description of the drug, indications, contraindications, analogues

Among a large number of antibiotics, few are distinguished by such properties as a wide range of effects. The drug "Amoxil", which is testified about its effectiveness against most pathogens, is attributed to such drugs. It is about him that will be discussed in this article.

Description of the drug: formulation, composition

The agent "Amoxil" is available in the form of tablets for oral administration with an active ingredient (semisynthetic amoxicillin) content of 250 and 500 mg. Tablets have a round, flat-cylindrical shape with a risk on one side and chamfers. Their color varies from white to slightly yellowish. Tablets with a dosage of 250 and 500 mg are packed in 10 pieces in contour cell packs (blisters), which are placed in cardboard boxes. Each box contains two contour packs with tablets, as well as instructions for using the drug. Tablets with a dosage of 625 mg are packed in blisters of 7 cells, which are also placed in cardboard boxes.

Storage and dispensing from pharmacies

According to the instructions for use, "Amoxil" tablets are dispensed from pharmacies only on the prescription of a doctor. The permissible period of use of the medicinal product is limited to two years from the date of manufacture. In this case, it is necessary to pay attention to the conditions under which tablets were stored. The drug "Amoxil" instruction is advised to keep in a cool room, the temperature in which does not exceed 25 degrees. It should also be ensured that direct sunlight does not fall on the package with tablets, as this can cause a number of undesirable reactions that will lead to loss of medicinal properties. Do not use tablets that have been stored in inappropriate conditions. The drug with the expired shelf life should be disposed of.

Pharmacological properties of the preparation

As mentioned above, the drug "Amoxil" is an antibiotic with a wide spectrum of action. According to its group membership, it refers to aminopenicillins. What is the peculiarity of the effect on this organism of microorganisms? The fact is that amoxicillin under the influence of several factors breaks down, resulting in a compound that is able to inactivate certain enzymes and structures in pathogens, and also to inhibit the process of regeneration and the formation of cell walls in them.

The drug "Amoxil" is active against such pathogens as gram-positive and gram-negative cocci and rods, anaerobic and microaerophilic streptococci, spirochetes and chlamydia. According to laboratory data, the drug is not effective against fungi, plasmodia, amoeba, mycobacteria, viruses and mycoplasmas.

The drug "Amoxil" is absorbed by the body quickly enough. The concentration of the active substance in the blood reaches a maximum already within 2 hours after taking the drug. Amoxicillin is found in the tissues of the liver and gallbladder, skin, subcutaneous adipose tissue, muscle fibers, synovial and perinatal fluids, and also into pus. It was found that the drug has a low degree of connection with proteins (about 18%).

The half-life of the drug is about 2-4 hours. The major part of the drug (not less than 60%) is excreted through the urinary organs unchanged.

When to take Amoxyl tablets

The drug is recommended for use in infections caused by the activity of microorganisms that have a sensitivity to amoxicillin. The drug "Amoxil" (500 or 250 mg) helps to cope with the following diseases:

• Sinusitis, tonsillitis and otitis media of bacterial origin;
• Bacterial infections of the organs of the gastrointestinal tract, including those caused by the microorganism Helicobacter pylori;
• Pneumonia and bronchitis of bacterial origin;
• Infections of the urino-genital organs, including gonorrhea, pyelonephritis, cystitis;
• Infection of soft tissues and skin due to injuries, surgical intervention.

In addition, the drug is widely used in the postoperative period to reduce the likelihood of infection.

It is worth recalling to readers that the "Amoxil" tablet is recommended for use after consultation with the attending physician, since the disparity between the preparation and the pathogenic microorganisms can lead to an aggravation of the patient's condition.

Contraindications for use

The list of contraindications to the use of the drug "Amoxil" is primarily hypersensitivity to amoxicillin and other components of tablets. Also, do not use this medication for persons diagnosed with "lymphocytic leukemia" and "infectious mononucleosis". It is considered unsafe to take the drug "Amoxil" for children under the age of three. It is also not recommended to take the drug to women during lactation.

Dosage and methods of treatment with the drug "Amoxil"

Rules for the dosage of antibiotics are regulated exclusively by medical indications, which include, in addition to the condition of the patient, the type and form of the disease, such indicators as the degree of damage to the body and the patient's individual response to taking the drug, its age and body weight. This applies to the drug "Amoxil". How should I take this medicine? There is a standard scheme for taking and dispensing a drug depending on the age and body weight of the patient. So, let's consider the rules of taking the drug.

Children aged 3 to 10 years, according to the instructions, tablets should be taken twice a day for 375 mg of the drug "Amoxil". According to the indications, the drug can be taken three times a day for 250 mg. Thus, the daily dose for this age group is 750 mg amoxicillin.

For children aged 10 years, the recommended daily dose is 1000-1500 mg of the drug "Amoxil" (500-750 mg twice a day or 375-500 mg three times a day). This dosage is also suitable for adult patients with mild or moderate disease.

In the chronic form of the disease (in the period of relapse), the drug is administered to adult patients in a dosage of 2250-3000 mg per day (divided into three doses). For children with chronic forms of disease, the dosage is calculated based on the body weight: the daily dose is 60 mg of the drug per kilogram of the child's weight (the total is divided into three meals per day).

In a number of diseases, dosage adjustment of the drug "Amoxil" is required. The instruction in this regard contains the following observations:

1. In case of violations of kidney function (QC 15-40 ml / min), an interval between receptions of at least 12 hours is required. In more severe cases, when the QC does not reach 30 ml / min, the daily dose of the drug should not exceed 1500 mg. The time interval of 12 hours between receptions should also be observed.
2. Anuria is a weighty reason to reduce the daily dose of the drug to 2000 mg. It is recommended that you take the pill three times a day.

Before prescribing this medication, it is recommended that all necessary studies be performed to identify factors that may play a role in determining the dosage.

Adverse reactions, overdose

During the reception of the drug "Amoxil" may with varying probability develop side reactions from some organs. Most often patients suffer from dysbiosis and candidiasis of the intestines, which are expressed in violation of the process of digestion of food, excessive gas generation, diarrhea and nausea. From the side of the nervous system, such conditions as hyperactivity and dizziness may also develop. Often, patients are prone to skin itching and other manifestations of an allergic nature (hives, angioedema, edema).

The following violations of the body during the reception of the drug "Amoxil" Mentioned very rarely:

• From the digestive system: hemorrhagic or pseudomembranous colitis ;
• From the skin: vasculitis of allergic origin;
• From the side of urinary organs: nephritis (interstitial), crystalluria;
• Hemopoiesis: hemolytic anemia, leukopenia and thrombocytopenia.

Sometimes patients with the drug may develop diseases such as Stevens-Johnson syndrome, candidiasis of the mucous membranes of the mouth or genitals, hepatitis and erythema multiforme.

When symptoms appear that indicate adverse reactions, it is necessary to temporarily stop taking the medication and consult a doctor.

Interaction with other drugs

Often, the drug "Amoxil" should be combined with the intake of other medicines. What can this lead to? You can find out about this from the table below.

When appointing any medicine during the period of treatment with the drug "Amoxil" it is recommended to inform the attending physician about it. This will help to avoid a number of complications.

special instructions

During the treatment of diseases with the drug "Amoxil" the instruction recommends maintaining a diuresis in the norm, since there is a probability of the appearance of crystalluria. In order to avoid this phenomenon, the patient should use an increased amount of fluid throughout the course of therapy.

Amoxicillin in case of contact with tooth enamel can cause a change in its color. To avoid negative consequences, it is recommended to observe oral hygiene during taking the drug. First of all, this applies to children, as they often chew on tablets.

Long-term treatment with the drug "Amoxil" can provoke the development of pathogens of resistance to its active substance. The same effect can occur and with a second course of treatment of the disease with this drug. The most serious consequence of this phenomenon is the development of superinfection.

During pregnancy, the drug "Amoxil" (analogues for the main active substance also fall under these recommendations) is prescribed only if the benefit for the expectant mother significantly exceeds the risk for the fetus.

During treatment with a drug, it is not recommended to manage complex mechanisms and motor vehicles, since unwanted reactions from the nervous system in the form of dizziness or blocking occur quite often.

Reviews about the drug

Reviews about the drug "Amoxil", received from doctors, almost have no negative connotation. The only thing that specialists pay attention to is a lot of additional factors that can affect the development of side effects when treating this drug. In addition, doctors noted a high level of effectiveness of the drug, even if there are several pathogens in the body of patients.

Patients also respond about the pill positively. What do they like most or do not like in the drug "Amoxil"? The price of the medicinal product by consumers is regarded as affordable (from 120 rubles per package). In addition to the excellent cost of the drug, consumers note that when treating the drug, dysbiosis often develops. Especially often with this disease, those patients who took the drug for a long time and in large doses were encountered.

Analogues of "Amoxil" tablets

To date, the pharmaceutical market offers several analogues of the drug "Amoxil". The price of these drugs in most cases is the same as the drug, which is discussed in this article. However, quite often on the drugstore shelves there are identical tablets that are several times more expensive. In some cases, such medicines can be replaced with "Amoxil" prescribed by the attending physician. The analogs should contain the same active substance - amoxicillin. This is worth paying special attention, because when prescribing a medicine, the attending physician took into account the type and type of infection the patient has. Analogues of tablets "Amoxil" for active substance are considered preparations "Amoxiclav", "Bactoklav", "Flemoxin Solutab" and "Amoxicillin".