Thiamin hydrochloride - instructions for use, composition, reviews and contraindications

The importance of vitamin B1 (thiamine) for the human body can not be overestimated. Unfortunately, in modern medicine quite often there are cases when additional administration of this substance is simply necessary. It was then that the use of the drug "Thiamine hydrochloride" was shown. What are the properties of the medicine? When is it necessary? These questions are of interest to many patients.

The drug "Thiamin hydrochloride": a brief description

This agent is released as a solution for intramuscular injection. It is usually colorless (sometimes there may be a faint hue), with a characteristic mild odor. It is placed in ampoules of neutral glass. It is released in boxes of 5 or 10 ampoules.

The main active substance in this case is thiamine hydrochloride. In 1 ml of the solution contains 50 mg of the main component. As excipients used purified water for injection, as well as unitiol. By the way, today more and more often used analogue of the drug called "Benevron".

The main properties of the drug

Thiamine is a medicament that helps to normalize the work of the whole organism. After all, this vitamin is an indispensable participant in many metabolic reactions. Once injected into the muscle, the solution is rapidly absorbed and distributed throughout the body. Increased its content in the tissues of the liver, the nervous system, as well as in the myocardium and skeletal muscles, since this is where its consumption is increased.

In the tissues of the body by phosphorylation, thiamine hydrochloride is converted into an active coenzyme of certain metabolic reactions. This substance takes part in the metabolism of lipids, carbohydrates and proteins. In addition, some forms of thiamine affect the process of nerve impulse transmission in synapses. Neutralizuetsya drug in the tissues of the liver, and then excreted by the kidney along with urine.

Indications for use

In fact, there are a large number of conditions in which the introduction of additional amounts of vitamin is advisable.

• The main indication in this case is hypovitaminosis or vitamin B1 vitamin deficiency. A similar condition is often observed in people on hemodialysis or probe nutrition.
• The drug is also prescribed in the presence of various dystrophic processes that are observed in fasting, atony, myocardial dystrophy, severe liver diseases.
• As prevention of vitamin deficiency, additional thiamine is prescribed to people with increased needs, for example, during intensive and rapid growth, during pregnancy and breastfeeding.
• The drug is also indicated for severe intoxication of the body, including thyrotoxicosis and chronic alcoholism.
• Thiamin helps to cope with certain diseases of the nervous system, including various neuralgia, neuritis, paresis and paralysis, radiculitis.
• Some skin lesions, in particular psoriasis, dermatoses, eczema and lichen, are also considered indications for the administration of thiamine solution.

The drug "Thiamine hydrochloride": instructions for use

Of course, to begin with, you need to consult a specialist - it is the doctor who determines the daily dose and duration of treatment. Thiamine is a solution for intramuscular injection. As a rule, therapy starts with small doses of medication. To begin with, inject no more than 0.5 ml of a 5% solution (this corresponds to 25 mg of the active ingredient). In the event that the drug is well tolerated, the dose is gradually increased.

The recommended amount of thiamine hydrochloride for adult patients is 25-50 mg - they inject 0.5-1.0 ml of the solution once a day. If it is a question of treatment of children, the daily dose, naturally, is less and makes 0,25 ml of a solution (12,5 mg of thiamine). The course of treatment, as a rule, lasts from ten to thirty days.

It should be noted that oral administration of the vitamin is more preferable. The solution for injections is used only in the event that the administration of tablets is impossible, which is observed, for example, in the pre- and postoperative period, as well as in the syndrome of malabsorption, severe nausea, accompanied by vomiting.

Are there any contraindications?

In fact, contraindications to the use of the drug "Thiamine hydrochloride" is not so much. Naturally, first of all it is worth noting that it is forbidden to take medicine for people with hypersensitivity to any of the components of the remedy. In addition, it is not prescribed for patients with hypervitaminosis thiamine. Symptoms of an excess of vitamin B1 include increased sweating, tremors, dyspnea, spasms of the pharynx. By the way, hypervitaminosis is extremely rare, since thiamine is a non-toxic substance. Most often, the cause of hypovitaminosis is an overdose of drugs.

Possible side effects

Fortunately, the drug "Thiamine hydrochloride" is almost completely safe. Only occasionally can there be side effects, which are reduced to an allergic reaction. In particular, such include hives, the occurrence of itching and redness. Quincke can sometimes be swollen. In the most severe cases, anaphylactic shock can develop. If you have these symptoms, stop using the medication and contact your doctor as soon as possible.

By the way, redness can occur at the injection site, small swelling, as well as soreness - these are completely normal phenomena. It is worth noting that most often side effects occur in women in menopause, as well as in people with chronic alcoholism.

Overdose and its symptoms

When using too large doses of the drug "Thiamine hydrochloride", an overdose is possible. What are its symptoms? In most cases, there is an increase in side effects. Nevertheless, other symptoms are possible. People who for a long time take too large doses of the solution, often complain of severe headaches. In some cases, there is tremor, as well as an increase in heart rate. Sometimes there is insomnia and increased excitability. In case of fear, it is best to consult a doctor immediately. There is no effective antidote to the drug, therefore, for therapeutic purposes, the administration of the Thiamin Hydrochloride solution is stopped and symptomatic treatment is performed.

Interaction with other drugs

Before starting the use of the medicine, you must tell the doctor about the drugs that you are taking, as some products with thiamine do not combine. For example, the solution should not be used simultaneously with medicines containing sulphides, since they completely neutralize the substance. In turn, pyridoxine slows down the process of converting the thiamine solution into a biologically active form. It is forbidden to simultaneously use thiamine hydrochloride and cyanocobalamin, as the probability of developing an allergic reaction increases.

It is also worth noting that vitamin B1 is not stable in alkaline and neutral solutions, so mixing it with citrates, barbiturates and carbonates is not recommended. It is impossible to mix in one syringe the rasters of the vitamin and some antibiotics, because under the influence of the first antibacterial substances are destroyed. Solution for injection "Thiamine hydrochloride" can weaken the effect of depolarizing muscle relaxants. It is also worth noting that during therapy, you should not drink alcohol at all, since ethyl alcohol slows down the rate of vitamin absorption.