The drug 'Siofor 1000'

The preparation "Siofor 1000" - white coated biconvex oblong tablets with a notch for division on one side and a wedge-shaped depression on the other. The blister contains 15 tablets. In the boxes there can be 2, 4 and 8 blisters. Country of production - Germany. Pharmacological group - biguanins (antidiabetic drugs). The non-proprietary international name is metformin. It is released by prescription. Storage temperature should not be more than 30 degrees. Shelf life is 3 years.

The preparation "Siofor 1000". Instructions

It is used for non-insulin dependent diabetes mellitus. The medicine "Siofor 1000" for weight loss is prescribed for people suffering from obesity. Metforminum after intake is absorbed in part (not completely). Bioavailability varies from 40 to 60%. Metformin is distributed rapidly in the body. In blood plasma, its maximum concentration is reached for an hour for 2. Removal of the drug occurs through the kidneys. The half-life period from plasma can be from one and a half to four and a half hours. In healthy individuals, the clearance of metformin is 40 ml / min. The half-life of metformin from plasma increases in persons suffering from renal insufficiency.

pharmachologic effect

Metformin contained in the preparation "Siofor 1000" helps increase blood circulation in the liver and accelerate the process of converting glucose into glycogen, reducing the content of triglycerides. When it is used, the cholesterol content decreases, the fibrinolytic properties of the blood improve. It also stimulates the absorption of glucose by muscle cells, reduces its concentration in the blood, stabilizes body weight.

Dosage

The doctor sets the dosage individually for everyone, taking into account the level of glucose. Therapy is recommended to be carried out gradually, gradually increasing the dose, starting from 500 mg once or twice a day during meals.

The required daily dose is 2 tablets, the maximum is 3. The tablets are taken with water when eating.

Side effects

Abdominal pain, nausea, vomiting, diarrhea, loss of appetite, weakness, drowsiness, flatulence, metallic aftertaste, hypoglycemia, dermatitis, megaloblastic anemia. When they occur, you need to either reduce the dose or temporarily stop taking the drug.

Drug Interactions

The use of the preparation "Siofor 1000" at the same time with hypoglycemic agents, salicylates, oxytetracycline, MAO and ACE inhibitors, cyclophosphamide, clofibrate can lead to an increase in the hypoglycemic action of metformin.

When used with glucocorticosteroids, adrenaline, contraceptives, glucagon, phenothiazine derivatives, thyroid hormones, as well as nicotinic acid derivatives, a decrease in the hypoclikemizing effect of metformin can occur.

Contraindications

The medicine "Siofor 1000" is not recommended for use in exacerbation of chronic infectious diseases, with acute infections, injuries, the danger of dehydration, acute surgical diseases, before surgery, radiology.

Also, it is not recommended to use the drug for severe violations of liver and kidney function, cardiovascular, respiratory failure, myocardial infarction, diabetic ketoacosis, diabetic retinopathy, alcoholism, anemia, pregnancy, children under 12 years.

special instructions

When passing the course of treatment, it is necessary to monitor the functioning of the kidneys, at least twice a year to detect the level of plasma lactate. In the case of lactic acidosis, treatment should be discontinued. When combined with insulin, inpatient treatment is recommended. The drug should be used with caution to people over 60 years old, as well as individuals with high physical exertion.