The drug 'Prestan'. Instructions for use. Description of the medicine

The drug "Prestans" (tablets) is a fixed combination of two well-known drugs "Amlodipine" and "Pre-Stary A". Today, according to experts, this tool is one of the most fruitful. This antihypertensive combination allows not only effective but also safe, in adequate time to lower blood pressure in patients with varying degrees of arterial hypertension.

According to the manufacturer, Prestans is successfully used in more than thirty countries.

Both substances in the drug contribute to the restoration of the elasticity and softness of the vessel wall. The drug prevents, thus, the development of stroke and heart attack. Along with this, studies have shown a good tolerability of the drug. The manufacturer claims that after taking the product there is no puffiness, headache, cough, which is explained by the properties of the active substances.

The medicine is available in four combinations. So, the preparation "Prestanz" 10/5, 5/5, 10/10, 5/10 is issued. In combination, the first figure indicates the content of perindopril arginine (drug "Prestarium A"), and the second - amlodipine benzylate. The dosage is indicated in milligrams.

The drug "Prestans" instruction for use recommends with IHD and hypertension.

The perindopril used in the treatment is used to treat elevated blood pressure of varying degrees of severity. When taking the remedy, there is a decrease in both systolic and diastolic pressure. Perindopril helps to reduce the overall peripheral resistance in the vessels, this leads to a decrease in blood pressure, as well as improvement of peripheral blood supply without changes in the frequency of heart contraction. When taking the drug, the kidney blood flow increases. At the same time, the glomerular filtration rate is unchanged.

The active component perindopril has a vasodilating property, it helps to reduce hypertrophy in the left ventricle.

The antihypertensive effect of the drug "Prestan" (instruction on the use of this indicates this) reaches a therapeutic maximum after a single dose after 4-6 hours and lasts no less than 24 hours. At the same time, a decrease in blood pressure is observed almost immediately after administration.

A persistent therapeutic effect is observed after one month from the first application. The patient's condition is not accompanied by tachycardia. At the termination of treatment, there is no withdrawal syndrome.

The amlodipine component inhibits the transmembrane transition into smooth muscle cells in the vessel walls and cardiomyocytes of calcium ions. The substance has a direct effect on the smooth muscle cells. The ability of amlodipine to provoke the expansion of peripheral arterioles is proved, reducing the overall peripheral vascular resistance. At the same time, the heart rate remains unchanged, and the need for oxygen in the myocardium does not increase.

Contraindications to the use of the drug "Prestans" instructions for use include hereditary lactose intolerance, glucose-galactose malabsorption, lactase deficiency, age to eighteen years, renal insufficiency, hypersensitivity to components. The drug is not prescribed for severe arterial hypotension, angioedema, history of asthma, unstable angina, obstruction of the exit path in the left ventricle.

The drug "Prestans" instructions for use prohibits the appointment during pregnancy.

The medicine is usually prescribed on a pill once a day. It is advisable to take the medication in the morning, before breakfast. The dosage of the drug is determined individually.

Before using Prestans, you should consult your doctor.