"Nitrosorbide" - analogues. Instruction, application, description of the preparation

Chronic heart failure is a serious problem for both the elderly and young patients. Supportive therapy is of great importance. The patient should regularly take pills to lead a normal life. A qualified cardiologist should prescribe the drug. The tablets "Nitrosorbide" are popular among specialists. Analogues are used less often.

Form of issue and composition

Tablets belong to the group of antianginal drugs. The main active ingredient is isosorbide dinitrate. As auxiliary substances, magnesium stearate, lactose monohydrate, polyvinyl acetate and talc are used. Tablets are available in white, have a round shape.

The main active ingredient, which is organic nitrate, helps relax the smooth muscle walls of the vessels. The effect is not only on the arteries, but also on the veins. Significantly reduced the deposition of venous blood, decreases venous return to the heart. Isosorbide dinitrate has a good clinical effect . The instruction for use states that the main component is quickly absorbed into the blood. Thanks to this, the therapeutic effect comes quickly and is long-lasting.

Pharmacokinetics

After entering the stomach, the tablets dissolve within a few minutes. For several hours you can already see the first results from therapy. Tablets are rapidly absorbed. The primary bioavailability of the drug is 22%. The maximum effect is achieved 2 hours after taking the tablet inside. The main active ingredient binds to blood proteins by 30%.

The medicine is completely removed from the body after 12 hours. There is no cumulative effect. Isosorbide dinitrate is metabolized in the liver. In this case, an active metabolite of isosorbide mononitrate is formed. The drug is almost completely removed with urine.

Indications

Only a qualified cardiologist can be prescribed tablets "Nitrosorbide". Analogues are also appointed by the expert on the indications. The drug can be used for ischemic heart disease, if long-term treatment with other medications has not given a positive result. Tablets can prevent attacks of angina pectoris.

In combination therapy, a drug called Nitrosorbide may also be prescribed. Analogues can be used such: "Cardiket", "Izo Mik", "Dikor Long". These drugs will be described a little lower. Tablets can be used in conjunction with cardiac glycosides, diuretins or inhibitors.

What else does the Nitrosorbide tablets have? The medicine also helps with myocardial infarction. The medication is prescribed after the seizure as a prophylaxis. As part of combination therapy, the drug can also be used to prevent angina pectoris. Tablets in this case have a prolonged action.

Treatment with Nitrobide is possible during pregnancy and lactation. However, use the medicine with caution. The medicine is prescribed only if the potential benefit to the mother exceeds the possible harm for the baby.

Contraindications

The medication is dispensed only by prescription. This avoids the misuse of tablets by patients. The fact is that the drug "Nitrosorbide", like the "Cardiket Retard", has some contraindications. In no case should you use the medicine during an acute myocardial infarction if you have severe arterial hypotension. In this case, the tablets may have the opposite effect. No medication is also prescribed for closed-angle glaucoma, hypovolemia, acute vascular insufficiency. Do not take medicine for craniocerebral trauma.

There are also age limits. Tablets "Nitrosorbid" or "Cardiket Retard" can be prescribed only to adults. Some patients may have increased sensitivity to nitrates. If you experience any allergic reactions, stop taking the medication immediately and seek advice from a cardiologist.

special instructions

To stop angina attacks , tablets "Nitrosorbide" can not be used. The same can be said about the medicines "Izo Mik", "Kardiket" and "Dikor Long". All these drugs can be used only for the purpose of prevention. If the attack is unavoidable, therapy with other medicines will be required. During the use of Nitrosorbide tablets, it is necessary to regularly monitor the heart rate and blood pressure. Patients with chronic heart failure treatment is desirable to undergo in a hospital.

Drug abolition is not recommended. The intake of "Nitrosorbide" at the beginning of therapy can contribute to an increase in the number of attacks of angina pectoris. The same effect can be observed also with a sharp drug cancellation. To arrest seizures during therapy, high-speed nitrates can be used, which a cardiologist should appoint. Self-medication can give unpredictable results.

Do not drive the vehicle if you need to use a preparation containing isosorbide dinitrate. Instructions for use say that this substance can cause drowsiness and dizziness. It is not recommended to manage any complex mechanisms during the treatment period.

Dosage

Tablets have a prolonged action. Patients with heart failure are prescribed 20 mg once a day. Gradually, the dosage increases. The maximum norm should not exceed 3 tablets per day. In more complex cases, prolonged action (40 mg) can be prescribed. Patients take half the pill twice a day. Increase dosage with caution and only under medical supervision.

Treatment begins with minimal doses and gradually increases the norm to the maximum effective. Designed for long-term use of the tablet "Nitrosorbide". Analogs are also meant for long-term therapy. Sharply discontinuing treatment is not recommended. Side effects can develop.

Overdose

Strictly on the recommendation of a doctor, it is necessary to use Nitrosorbide tablets. Reviews show that an overdose can provoke the development of side effects. They appear more often in the form of dizziness, nausea, vomiting. Less often, skin reactions may occur, such as itching, rashes. From the side of the cardiovascular system, the patient can feel a significant decrease in blood pressure, heart palpitations.

Treatment of overdose can be carried out only in a hospital. First of all, the stomach is washed. In the future, symptomatic therapy is prescribed. To quickly stabilize the patient's condition, activated charcoal can be used.

Adverse events

When properly used, tablets can also develop side effects. In most cases, they are only temporary and can not be canceled. Unpleasant symptoms at the beginning of therapy can also cause tablets "Dikor Lorg", "Izo Mik", "Kardiket". Initially, patients may have a headache, which is not eliminated by any medication and goes away by itself a few days after the start of therapy. There may also be tachycardia, lowering blood pressure.

On the part of the digestive system, side effects are manifested in the form of nausea, abdominal pain, diarrhea. If vomiting occurs, seek medical advice immediately.

Drug Interactions

Caution should be used tablets "Nitrosorbide" with any vasodilator drugs. Such interaction can lead to the development of side effects. Dihydroergotamine tablets can only be used after consultation with a doctor. The interaction of drugs can lead to an increase in the concentration of dihydroergotamine in the blood and enhance its hypotensive effect.

Promotes improvement of blood circulation joint application with tablets "Nitrosorbide" of acetylsalicylic acid. Along with adsorbents, the drug is not recommended. Such interaction will lead to a decrease in the bioavailability of the drug.

Analogues

The tablets "Nitrosorbide" are popular among specialists. The price of the drug is low, and it has a positive effect on the body. But it is not always possible to find a drug in a pharmacy. A cardiologist will always help to pick up qualitative analogues. Tablets "Cardiket" also perfectly cope with the task. The main active ingredient of the drug is the same isosorbide dinitrate. The drug is prescribed for the prevention of angina pectoris, as well as myocardial infarction.

More expensive analogue are tablets "Dicor Long". As auxiliary components in tablets are used corn starch, lactose monohydrate, silicon dioxide colloid, magnesium stearate, titanium dioxide. Tablets can be given to children, as well as pregnant women in a hospital.

Tablets "Izo Mik" - another popular tool that can replace the drug "Nitrosorldide". The main active ingredient is also isosorbide dinitrate. Of all the medicines listed, this is the most expensive.

Reviews about tablets "Nitrosorbid"

The drug has a good effect on the cardiovascular system. At a heart failure of an average degree first of all tablets "Nitrosorbidum" are appointed. The price of the medicine pleases the patients. One package can be purchased for only 15 rubles. Negative reviews may be associated with adverse events that occur at the beginning of therapy. It is worth remembering that they are only temporary.

It is not recommended to use the medication yourself. Treatment should be carried out strictly under the supervision of a specialist who will determine the correct dosage in each specific case. Sharply cancel therapy also should not be.