'Ketotifen' preparation: reviews and instructions for use

The drug "Ketotifen" belongs to the group of cycloheptathiophenone agents, which have a pronounced antihistamine effect.

The mechanism of action of the drug "Ketotifen"

The doctors' comments indicate that the drug inhibits the release of mast cells from histamine, blocks histamine receptors, inhibits phosphodiesterase enzymes. When using the drug, the level of cyclic adenosine monophosphate in mast cells increases. The medication is involved in suppressing the effects of thrombocyte-activating factors. The medicine does not produce relief of asthmatic attacks, but only prevents their occurrence, reduces intensity and duration, in some cases, their complete disappearance occurs. The drug has a positive effect on the sputum.

Composition and pharmacokinetics of the preparation "Ketotifen"

Reviews of pharmacists and instructions for use indicate the presence of the main active ingredient in the drug - ketotifen fumarate.

The drug is almost completely absorbed by the body. Bioavailability of the drug is 50 percent, the drug overcomes the blood-brain barrier. Metabolism occurs in the liver, the drug is excreted as metabolites by the kidneys. The bulk of the substance is released through the kidneys for two days.

Indications for taking Ketotifen

Reviews and recommendations of doctors describe the drug as an effective tool for the therapy of atopic bronchial asthma and dermatitis, hay fever, allergic rhinitis and conjunctivitis, and hives.

The medicine is produced in the form of 1 mg tablets and "Ketotifen" syrup.

Children over the age of 3 years are prescribed 1 mg of the drug in any form 2 times a day. Adults should take the same amount of medication in the morning and evening. If necessary, the dose is doubled. The medicine is consumed with food inside. The duration of therapy is 3 months. Cancellation of treatment is made within two weeks.

Contraindications and side effects from taking Ketotifen

The patients' testimonies testify to such negative phenomena as dizziness, drowsiness, slowing of reaction speed, feeling of fatigue. When using the drug, there is a sedative effect, sleep can be disturbed, anxiety, nervousness in children may arise. In addition, patients feel dry mouth, they have an increased appetite, may start vomiting or nausea, constipation. To adverse reactions include thrombocytopenia, allergies, weight gain.

The drug "Ketotifen", syrup and tablets, is not recommended for use during pregnancy and during lactation. It is forbidden to take medication for children under three years old, as well as hypersensitivity to components.

Ketotifen: special instructions

It is undesirable to make a sharp abolition of the drug for patients with bronchospastic syndrome and bronchial asthma. Treatment is stopped smoothly, reducing the dosage within two to four weeks.

Patients who are sensitive to sedation, the drug is prescribed in small doses. The medication is not intended for therapy of asthma attacks. With the joint appointment of hypoglycemic agents should monitor the amount of platelets in the peripheral blood.

The drug affects the ability to drive vehicles and mechanisms, so you should refrain from these works during treatment.

The drug increases the effect of sleeping pills, ethanol and antihistamines, and in combination with hypoglycemic drugs increases the risk of developing thrombocytopenia.

Similar medication is provided by preparations Zaditen, Ketof, Stafen, Positan.