"Geksoral Tables": instructions for use, reviews

How and for what should I take the drug "Geksoral Tubs"? The instruction of this medication, its indications and contraindications will be described in this article. From it you will learn and about what other forms this medicine has, whether it is possible to use it during pregnancy, whether the drug has side effects and so on.

Composition of the medicament

In what form is the drug "Hexoral Tabs" manufactured? On sale it comes in the form of resorption tablets, which have a biconvex and round shape, and also a rough surface of a yellowish color.

The active substance of the drug is chlorhexidine dihydrochloride and benzocaine. As for the auxiliary components, they include isomalt, peppermint oil, menthol, aspartame, thymol and purified water.

Pharmacological characteristics of the drug

What are the properties of tablets "Geksoral Tables"? A good therapeutic effect of their intake is due to the composition of the medication.

The combined preparation "Geksoral Tabs" for topical use has antibacterial activity. It is due to the presence of a substance such as chlorhexidine. As for benzocaine, it is a local anesthetic that provides relief from pain symptoms.

Details about the properties of the medicament

Chlorhexidine, which is part of the drug "Hexoral Tables", has a good antibacterial effect against gram-negative and gram-positive bacteria. After entering the body, the active substance destroys the cytoplasmic membrane of the bacterial cell. However, it is ineffective against dermatophytes, yeast fungi, mycobacteria and some species of Proteus and Pseudomonas.

To a greater extent, chlorhexidine dihydrochloride is effective in a slightly alkaline or neutral medium. In acidic, its activity is significantly reduced. In addition, the effectiveness of the drug is reduced in the presence of blood, soaps, as well as pus.

The use of tablets "Geksoral Tabs" leads to a significant decrease in the content of harmful microorganisms in saliva. In this case, the use of the drug for several weeks (or months) is accompanied by a decrease in its effectiveness. This is due to a decrease in the sensitivity of bacteria.

In addition to chlorhexidine dihydrochloride, the drug we are considering contains an active element, such as benzocaine. It is a local anesthetic, which very quickly removes pain in the pharynx and oral cavity. The analgesic effect lasts for a long time.

Benzocaine is able to penetrate through the lipophilic region of the cell membrane, and then act on the pain receptors (peripheral) of the skin and mucous membranes.

Anesthetic effect of benzocaine usually comes in 20-28 seconds after application. But as the active substance is diluted with saliva, the effect begins to gradually decrease.

Pharmacokinetics of the drug

The active element of the drug "Hexoral Tabs" (chlorhexidine) is able to persist in saliva up to eight hours. However, there are no clinical indices of its absorption through the mucous membrane of the human mouth.

With regard to benzocaine, then due to its low solubility in water it is absorbed rather slowly. Like all derivatives of ester-paraaminobenzoic acids, this substance is cleaved in the liver and plasma by esterase. As a result, ethanol is formed, which is metabolized to the acetylcoenzyme. As for para-aminobenzoic acid, it undergoes conjugation with glycine or exits the body through the kidneys in an unchanged form.

Indications for use of the drug

When is the "Hexoral Tabs" medication prescribed? The instruction of this preparation contains the following list of indications:

• Angina, pharyngitis and other inflammatory diseases of the pharynx;
• gingivitis;
• stomatitis.

Contraindications to the use of the drug

In what cases is it forbidden to use the drug "Geksoral" (aerosol, absorbable tablets)? According to the attached instructions, the use of this medication is prohibited in the following cases:

• With phenylketonuria;
• With ulcers and wound lesions of the pharynx or oral cavity;
• At a low concentration of cholinesterase in the blood;
• If the child is not yet 4 years old;
• With increased sensitivity to the elements of the drug.

Medication "Geksoral Tables": instructions for use

This medication is used only topically. The tablet should be slowly resorbed in the mouth (until its complete dissolution).

The drug should be used immediately after the appearance of the first signs of the disease. And the treatment must be continued for several days after the complete disappearance of all symptoms.

For adults and children over 12 years of age, the drug is usually given on the first pill every 1 or 2 hours (if necessary). However, the daily dosage of the drug should not be more than 8 tablets per day.

Children aged 4 to 12 years, the drug is prescribed in an amount not more than four tablets per day, the application is only possible for pediatricians.

The drug should not be given to children under 4 years.

Cases of overdose

Can an overdose of the drug "Geksoral Tabs" (classic, etc.) occur? With proper use of the drug, an overdose is not possible. After all, the active element - chlorhexidine - is not absorbed into the blood, and the volume of the absorbed benzocaine is low.

As stated above, chlorhexidine hydrochloride is very poorly soluble in water. Therefore, all cases of overdose are described only when taking a well-soluble chlorhexidine gluconate. Symptoms of this condition are damage to the mucous membranes as a result of direct contact with the active substance, as well as a systematic but reversible increase in the concentration of the hepatic enzyme. Specific therapy in this case is absent.

With regard to benzocaine, an overdose of this substance can occur only if the drug is used improperly. In this case, there is a toxic effect on the nervous system, which manifests itself first by tremors, convulsions and vomiting, and then by CNS depression. In the end, the patient can fall into a coma.

Among other things, high toxic concentrations of this substance cause blockade of AV-conduction, bradycardia and cardiac arrest. Also, benzocaine is the cause of the occurrence of methaemoglobinaemia (more often in young children), which is accompanied by cyanosis and suffocation.

How to treat? If an overdose of benzocaine occurs, the patient should be vomited and immediately rinsed. Sometimes doctors prescribe activated charcoal.

If the patient has hypoxia and anoxia, then artificial respiration is necessary. When the heart is stopped, a massage is required.

When cramps occur, the patient is prescribed high-speed barbiturates (only not with anoxic spasms) and "Diazepam". In especially severe cases, after artificial respiration and intubation, suxamethonium chloride is used.

The patient's blood circulation is maintained by administering solutions of electrolytes or blood plasma. With methemoglobinemia apply up to 50 ml of methylene blue solution (1%). Enter it intravenously.

Adverse events

Are there any side effects of the drug "Geksoral" (aerosol, tablets)? According to the instructions, this medication has a rather large number of negative consequences. They were identified during epidemiological or clinical studies.

• Digestive system: decreased sensitivity of the oral mucosa, impaired taste (or so-called dysgeusia), temporary numbness of the tongue, stomatitis, reversible discoloration of teeth and tongue, discoloration of composite and silicate materials of restoration of teeth, detachment of the oral mucosa, formation of tartar or plaque , Glossodynia, as well as an increase in the salivary glands (parotid).
• Human immunity: hypersensitivity reactions, including angioedema, hives, anaphylactic shock and other anaphylactic reactions.
• Lymphatic and circulatory system: methemoglobinemia.

If these side effects are exacerbated or other adverse effects not noted in the instructions are noted, the patient should be informed about this to the doctor.

Interaction with other means

Does the use of this drug affect the use of other drugs? What does the instruction say about this? "Geksoral Tabs" (classic, etc.) can reduce the antibacterial activity of aminosalicylates and sulfonamides. This is due to the formation of a metabolite of aminobenzoic acid.

As for the action of chlorhexidine, it decreases noticeably with the simultaneous use of sucrose, polysorbate 80, insoluble salts of zinc, magnesium and calcium.

The drug "Geksoral Tabs" in pregnancy

Currently, the experience of using the drug "Geksoral" (in the form of chewable tablets and aerosol) in lactating and pregnant women is absent. That is why its use is possible only in those cases when the expected benefit for the mother considerably exceeds the potential risk for the fetus or the child.

Special instructions on the use of medicament

What do you need to know for the safe use of the drug "Hexoral Tabs" (classic)? Feedback from experts about this tool is mixed: if used improperly, benzocaine can cause methemoglobinemia. A similar condition is accompanied by such signs as a change in the color of the lips, skin and nails. They become pale or acquire a blue, grayish shade. Also, the patient may experience a pre-fainting condition, headache, fatigue, dyspnea and tachycardia. The appearance of these symptoms indicates the presence of methaemoglobin in a high or moderate amount, as well as a significant decrease in the oxygen transport function of the blood.

The elder and small patients are at the highest risk of developing methaemoglobinemia. Children of this medication may take only under the supervision of adults.

The medication contains such an auxiliary element as aspartame. It is a derivative of phenylalanine, which is a clear danger to patients with phenylketonuria.

The use of the drug is strictly prohibited in the presence of ulcerative and wound lesions of the throat and oral cavity. Special care should be taken when prescribing the drug to young children (from the age of 4) and to people with swallowing or aspiration, as this can cause suffocation.

If the medicament "Geksoral Tabs" has expired , then it should not be disposed of into sewage water or into the street. The drug is recommended to be placed in a bag and sent to a garbage container. These measures will help protect and preserve the environment.

The medicine we are considering does not have any influence on the ability to drive the machine, or engage in other activities.

Other forms of release

In addition to tablets, the drug "Geksoral" is produced in other forms. Let us consider them in more detail.

• 0.1% solution for topical application. This medication contains hexetidine, as well as auxiliary elements such as anise and eucalyptus oil, ethanol, citric acid monohydrate, clove oil, levomenthol, polysorbate 60, methyl salicylate, peppermint oil, purified water, sodium saccharin and azorubin. The present agent is used only for rinsing the pharynx and mouth.
• Aerosol "Geksoral" (spray). The use of this drug is shown in the same cases as tablets. Spray should be sprayed on the affected areas for no more than 2 seconds. As a rule, it is prescribed twice a day (after breakfast and dinner). In severe cases, aerosol is used more often.

Reviews about the drug

According to the patients' reviews, the drug "Geksoral" copes well with the task. Thanks to him, angina and pharyngitis, as well as other inflammatory diseases of the pharynx, are transferred much easier and pass fairly quickly. As for negative reviews, most often they are left by those who used the medication incorrectly.