"5-NOC" - reviews about the drug

Despite the fact that the human body is immune and able to cope with many diseases on its own, there are bacteria and infections that can be defeated only with the help of medicines. Such drugs can suppress and stop the growth of pathogens, thereby eliminating the focus of inflammation. A group of such drugs include tablets "5-NOC". The patients' testimonies attest to their high effectiveness in the treatment of diseases of the urogenital system. In addition, this drug is great for preventing the occurrence of relapses of inflammation in chronic forms of diseases.

Active substance

Nitroxoline is an active active substance of the drug "5-NOC". It is a synthetic formation derived from 8-hydroxyquinoline. Thanks to this component, the drug, getting into the body, begins to look for cells of microorganisms and oppress their DNA. The mechanism of selective action allows to stop the multiplication of pathogenic bacteria and not to harm healthy cells.

In addition, nitroxoline is actively reacting with nucleic acids and enzymes that contain metals in their cells. The substance disrupts the process of recovery of pathogenic bacteria, has a pronounced bactericidal effect against a fairly wide range of microorganisms. In doing so, it is effective enough against strains resistant to preparations of other groups of antibacterial agents. The drug "5-NOC", the reviews confirm it, is an effective and inexpensive means against diseases caused by fungi, bacteria and pathogens of high resistance to other drugs of antibacterial and antiseptic action.

Form of issue and composition

The drug is available in the form of coated tablets. They have an orange or yellow color, round in shape, biconvex, a characteristic luster. The main active substance is nitroxoline. Auxiliary components of the composition: sucrose, dye E110, carboxymethylcellulose, lactose.

With what microorganisms is the medicament struggling

Note that the drug has a directional effect and is quite effective against certain strains of pathogens:

• Anaerobic and aerobic Gram-positive organisms - Enterococcus faecalis, Streptococcus spp. (Strains of pneumoniae, pyogenes).
• Staphylococcus spp., Strains of aureus, Bacillus subtilis, Corynebacterium spp.
• Anaerobic and aerobic microorganisms (Gram-negative) are Klebsiella spp., Proteus spp., Shigella spp., Salmonella spp., Haemophilus influenzae, Enterobacter spp., Escherichia coli, Neisseria gonorrhoeae.
• Infections caused by Mycobacterium tuberculosis, Mycoplasma hominis, Trichomonas vaginalis, Ureaplasma urealyticum.

Mold fungi, dermatophytes, Candida fungi, some organisms that cause deep fungal infections - these diseases also effectively stop drug "5-NOC". The doctors' comments testify to the ability of the drug to reduce the adhesion of uropathogenic organisms to the catheter wall (for urinating in patients) and the epithelial layer of the urinary tract.

When appointed

Due to a wide range of uses, the drug copes with the following ailments:

• Chronic, acute, recurrent diseases (infectious etiology) of the urinary tract caused by gram-negative and gram-positive fungi and bacteria.
• Epididymitis.
• Pyelonephritis: a chronic and acute form.
• Urethritis.
• Cystitis.
• Adenoma and carcinoma (infected) of the prostate gland.
• Prevention of infections (recurrent) urinary tract.
• Applied after diagnostic and surgical interventions on the urinary tract: kidney, cystoscopy, catheterization.

It should be noted that only a doctor can prescribe an adequate treatment depending on the severity of the disease. Tablets "5-NOC", expert reviews confirm this, have a high bioavailability - about 90%. They are quickly absorbed in the digestive tract and reach the highest concentration in the blood plasma after 1.5-2 hours.

Pharmacokinetics

The drug has a low ability to bind to plasma proteins. The highest concentration of active substance is found in the patient's urine. The drug is metabolized mainly in the liver, and is excreted by the kidneys. Some of the medicine is removed from the body with bile - the period is 2 hours. It should be noted that the data on the pharmacokinetics of the drug in children, people in old age and patients with insufficient kidney and liver function have not been studied. Therefore, it is necessary to get a qualified consultation of the doctor before prescribing the "5-NOC" tablets. Experts say that children tolerate the drug fairly well in case of full compliance with the dosage and treatment regimen. Particular care should be taken to monitor a child who is under 3 years of age.

How to use

It is recommended to take the medicine during meals or after it. Tablets are not chewed, swallowed whole, washed down with clean water. Adequate doses of the drug:

• Adult patients - from 100 to 200 mg, up to 4 times a day. Note that under the condition of continuous use of tablets, the course can not exceed 30 days. However, therapy with alternating courses is possible: 14 days of drinking pills, 14 days do not take medicine. This method allows for treatment for several months.
• Prevention of infectious diseases after surgical interventions, diagnostic manipulation - 100 mg to 4 times a day. This mode of taking medication lasts up to 3 weeks. For patients with impaired liver and kidney function, the initial dose is 50% of the recommended dose.

Note that the drug "5-NOC" with cystitis, patients' reviews confirm this, quickly relieves inflammation and eliminates acute pain syndrome. However, even in the event of a positive effect of treatment, it is not recommended to interrupt the course prescribed by the doctor, otherwise there is a risk of relapse.

Dosage for children

Please note that an adequate dosage for a child can only be determined by a doctor based on a survey. Usually the drug is prescribed as follows:

• For children from 2 to 12 months, the calculation is based on the body weight of the baby: 25 mg / kg per day. All the medicine must be divided into 4 divided doses. The duration of therapy is from 10 days to 3 weeks. In case of severe infection - up to 1 month.
• At the age of 12 months to 14 years, the intake of 50 to 100 mg is prescribed up to 4 times a day. The course is determined by a specialist, but with continuous admission, it can not exceed 30 days. When the alternation mode is 2 weeks - reception, but 2 weeks - a break, longer use of the drug "5-NOC" is allowed. For children, doctors' testimonials testify to this, the drug should be prescribed only in the most extreme cases, when therapy with the help of other medications was ineffective.

Possible side effects

Note that side effects in patients are rare, but it is necessary in the case of their appearance immediately seek medical attention. It is he who can cancel the medication and conduct symptomatic treatment after using the drug "5-NOC". Instruction, doctors' reviews indicate the following negative manifestations in therapy:

• Vomiting, impaired liver function, nausea, in rare cases, anorexia.
• Tachycardia.
• Paresthesia, polyneuropathy.
• Violated coordination of movements, dizziness, headache, less loss of consciousness.
• Optic neuritis (with prolonged use of tablets).
• Hives, rashes, peeling of the skin.
• Thrombocytopenia, sometimes staining the urine in a saturated yellow tint, an increase in the uric acid in the blood plasma.

As a rule, all side effects quickly disappear after the complete elimination of the "5-NOC" preparation. Patients' testimonials indicate a poor state of health only in case of an overdose or failure to adhere to the regimen.

Contraindications

If the patient has an allergic reaction or hypersensitivity to one of the components of the composition, it is forbidden to prescribe a drug. It is not recommended to use the medication for breastfeeding, cataracts, impaired liver and kidney function.

It is worth noting that the drug "5-NOC", the testimonies of women testify about this, often prescribed during pregnancy. In this case, there are no cases of damage to the health of both the future mother and the fetus. As a rule, the drug is prescribed for acute cystitis, vaginal infections and fungal manifestations (thrush).

Do not simultaneously take the medicine with medications that contain oxyquinolines. There may be toxic poisoning from an overabundance of the active substance in the body.