The drug "Lespenefril": instructions for use. Reviews

As everyone knows, the kidneys are a paired organ located in the abdominal cavity, more precisely in the retroperitoneal space of the lumbar region, and serving for the formation of urine. However, this is completely superficial information about them. Because they perform many other vital functions. Thus, a day they form about 150-200 liters of primary urine, obtained by filtering blood through their capillary glomeruli, and then due to its further transformations it remains 100 times smaller - 1.5-2 liters already secondary, that is, ready for urine release . It is concentrated, all toxins, harmful metabolites are filtered into it, and in the diseases it can get blood cells, bacteria, proteins, ketone bodies and much more. Thus, the kidneys rid the body of many toxic substances, thereby equally with the liver every minute saving your body from death.

Pathogenesis of kidney damage

But thanks to this blood flow in the kidneys, they become susceptible to many infections. Plus, they suffer a lot if a person leads an unhealthy lifestyle or has extrarenal pathologies. For example, arterial hypertension, atherosclerosis, diabetes mellitus, etc. And the extreme severity of this important condition is renal failure. In this case, the toxins unable to remove from the body begin to return to the blood: residual nitrogen, creatinine, urea, ammonia - they all poison the body, and primarily the brain, causing various kinds of encephalopathy and ultimately leading to coma. Therefore, to combat these deep disorders of the urinary system, a group of hypoazotemic drugs was created.

Preparations

These include ornithine (preparations Ornitsetil and Gepa-Mertz), lactulose (syrup Dufalac), amino acids for parenteral nutrition (Gepasol A solution) and herbal Lespidets (medication Lesdesflan and Lespenefril). The instruction for the use of these medicines informs buyers about their pronounced detoxification action, namely precisely in neutralizing ammonia, enhancing renal filtration and diuresis.

Thus, these drugs favorably affect the kidneys and contribute to the restoration of their functions. The price of "Lespenefrila" varies in different regions of the country, but on the average it is about 90-100 rubles per bottle. By the way, it is made of dark glass, so that the sun's rays do not affect the quality of the tincture and do not reduce its shelf life. And the price of "Lespenefril" in the form of a solution for oral administration is slightly lower than for tincture. However, both vials contain only 120 ml of the drug, which is usually not enough for the entire course of treatment.

Basis of the preparation

The tool "Lespenefril", the instruction on which application is happy with the brief, is easy to use. It is a medicinal product of plant origin, namely - spirituous tincture of Leschedeza capitate. It is a legume plant that contains catechins that are similar in activity to vitamin P in different parts, as well as flavones, that is, modified forms of bioflavonoids. On the basis of this natural remedy, medicinal preparations such as "Laspeflan" and "Lespenefril" are manufactured. The instructions for the use of these two medicines are generally similar. However, different types of lespeses are taken as a basis for the preparations. However, despite this, they both have pronounced anti-inflammatory and diuretic effects.

Bioflavonoids

In the body of lispedes, bioflavonoids act as signal molecules between different plant cells, and also protect the photosynthetic apparatus from damage by ultraviolet radiation and from the invasion of pathogenic microorganisms. However, in the human body, they are much more important for the kidneys.

So, the effectiveness of the drug "Lespenefril", the instruction for its application does not include a specific pharmacological mechanism of action, is explained by the direct effect of its biologically active substances. The fact is that bioflavonoids strengthen the capillary walls, which are damaged in the kidneys in most diseases. The latter include glomerulonephritis, pyelonephritis, interstitial nephritis, arterial hypertension, atherosclerosis, diabetes mellitus and many others.

Mechanism of action

Thus, this drug, which can also be attributed to traditional medicine, enhances blood circulation in the kidneys, namely, strengthens damaged earlier vessels, thereby restoring the function of this important organ. Specifically, the patient's blood concentration decreases the toxic metabolites of nitrogen, and diuresis also increases due to the active excretion of sodium ions, and together with them (to a lesser extent) and potassium. And all this provokes the drug "Lespenefril".

Analogues of this tool are also based on lepersade. One of them is the product "Laspeflan", which was mentioned above. To create other analogues of "Lespenefril", in fact, is inexpedient, since these funds are already effective, available and have a low cost. Of course, they are not independent medicines and require the use in combination with etiotropic and pathogenetic components.

Indication and method of application

Thus, nephritis (acute and chronic course), accompanied by hyperaemia, as well as the initial stage of renal insufficiency and hyperazotemia of extrarenal etiology are indications for the use of Lespenefril. Reviews of this herbal remedy are generally positive. This is primarily due to the cheapness of the drug and its prevalence in pharmacies.

The solution is taken internally in a daily dose of 1-2 teaspoons, but if necessary, it can be increased to 2-3 (maximum - 6). When switching to maintenance therapy, the amount is reduced to 0.5-1 tsp / day. With the reception every other day. The drug is best washed with clean water or slightly mineralized. The course of treatment is about a month, and it can be repeated after a break of 2-3 weeks. The only contraindications are the period of pregnancy and hypersensitivity to the components of the drug.