Medicinal remedy 'Contrikal'. Instructions for use

"Contrikal" is a drug used for the treatment of acute pancreatitis, bleeding, hemorrhage, which is a consequence of hyperfibrinolysis, severe hemorrhagic complications of post-traumatic, postoperative nature, shock conditions. The drug "Kontrikal" in tablets is not produced. The basic form of the release is a lyophilized powder, which is used for the preparation of injectable solutions. It is packed in special vials together with ampoules of the solvent.

The drug "Contrikal". Instructions for use: composition, pharmacological properties

The drug contains aprotinin, which is an active substance. Auxiliary components: sodium chloride, mannitol, purified water.

After the administration of the drug, the active substance is distributed in the extracellular spaces, accumulates in the hepatic tissue, then is excreted by the kidneys from the body.

The drug "Kontrikal", the mechanism of its action is based on the inhibition of proteases, suppresses the proteolytic action of plasmin, blocks the activation of plasminogen, carried out by autogenic activators. It reduces fibrinolytic functions of the blood, inhibits the fibrinolysis process, has haemostatic effects in coagulopathy. Blockade of kinin-kallikreinovoy system allows the use of the drug as prophylaxis for violations of other enzyme systems of blood.

Medicinal remedy "Contrikal". Instructions for use: dosage, side effects

The contents of one vial are dissolved in two milliliters of sodium chloride solution. Then it is administered to the patient, who should be in a recumbent position, intravenously striated. Patients who have an effusion in the abdominal cavity, acute necrosis of the pancreas, you can apply the drug intraperitoneally. In acute pancreatitis, 200,000 - 300,000 ATPE preparations are given, and then another such dose is administered within one day. For the prevention of fat embolism, with a variety of bleedings, a similar amount of the drug is used. It is important to administer the drug slowly, otherwise shock conditions may develop.

The use of the drug may be accompanied by a variety of adverse reactions. The main ones are arterial hypotension, dyspnea, nausea, skin pallor, heavy sweating, symptoms of anaphylactic type reactions. In rare cases, thrombophlebitis may develop at the injection site of the drug (with prolonged use). The drug sometimes causes an increase in the concentration of serum creatinine.

The drug "Contrikal". Instructions for use: contraindications, drug interactions

Use this drug is prohibited in the presence of hypersensitivity to the components, during pregnancy, lactation, in childhood.

The drug may reduce the activity of streptokinase. It suppresses the action of nonspecific cholinesterase of the blood plasma. It is forbidden to combine it with heparin, lactam antibiotics, corticosteroids.

Medicinal remedy "Contrikal". Instructions for use: special instructions, overdose

It is necessary to stop breastfeeding the baby during lactation if it is necessary to take the drug.

Symptoms of an overdose are similar to side effects, but they have a significant intensity. For their elimination are used drugs of symptomatic effect; Can be replaced by its analogues, which have less pronounced side effects.