"Gordoks": indications for use, contraindications, reviews

What is the drug "Gordoks"? Indications for the use of this tool will be presented below. Also we will tell you about the form in which this drug is produced, whether it has contraindications, how it should be used correctly, what side effects may appear after application, and so on.

Form of release of the medicinal product, packaging and composition

In what form can I buy a drug "Gordoks"? Indications for the use of this tool are such that it is most effective only with intravenous administration. Therefore the considered medical preparation is issued only in 10 ml ampoules in the form of a solution.

The active element of this drug is aprotinin. The medicine also includes such auxiliary components as water for injection, benzyl alcohol and sodium chloride. In one cardboard bundle there are 25 ampoules.

Pharmacological properties of medicament

What is the use of the drug "Gordoks"? Indications for use of this remedy include diseases of the digestive system. The active component of the drug has antiproteolytic, haemostatic and antifibrinolytic effects. It is effective in diseases of the pancreas. In addition, this medication is able to significantly reduce the fibrinolytic activity of the blood. It is very often prescribed as a preventive therapy of any type of shock conditions.

Principle of action of a medical device

What is the medicine "Gordoks"? Use in children and adults should be done only as directed by the doctor. This is due to the fact that this drug is an inhibitor of proteolytic enzymes, which has antifibrinolytic properties.

After the formation of reversible stoichiometric complexes, the active substance of the drug inhibits the work of tissue and plasma kallikrein, plasmin and trypsin. As a result of this effect, fibrinolytic activity of the blood decreases.

In addition, aprotinin is able to activate the contact phase of blood coagulation, inhibit numerous mediators, weaken inflammatory responses, reduce the formation of thrombin and fibrinolysis.

What is the drug "Gordoks" used for? Indications for use include surgical intervention. Thanks to this tool, the volume of blood loss decreases, as well as the need for blood transfusion.

Pharmacokinetics of the drug

How quickly does the drug "Gordoks" work? Application in veterinary medicine and therapy shows that, after intravenous administration, the concentration of the active component in the blood very soon decreases due to the distribution of the drug in the intercellular space. The initial half-life of the drug is observed after 0.4-0.8 hours, and the final half-life after 5-10 hours.

The connection with plasma proteins is 80%.

Aprotinin is mostly accumulated in the kidneys, and in lesser cases in the cartilaginous tissues. Accumulation of the drug in the kidney is due to its binding to the epithelial cells of the renal tubules. As for the accumulation in the cartilaginous tissues, this is due to the affinity of aprotinin, which, in fact, is their basis.

Accumulation of the active substance of the drug in other organs is comparable to its concentration in the plasma. At the same time, the lowest percentage of content is found in the brain. It should also be noted that a limited amount of aprotinin is able to penetrate the placental barrier.

The active component of the drug is metabolized in the kidneys (lysosomal enzymes) to inactive metabolites. In a small amount, aprotinin is excreted together with urine.

Medication "Gordoks": indications for use

Feedback about this tool, we will submit a little below. With regard to this section of the article, it would like to tell you about the purpose of this medication for patients.

So, indications for the use of this drug are the following pathological conditions:

• Pancreatitis in chronic form (the drug is used for frequent relapses, as well as for severe disease);
• Pancreatitis in acute form (a medical preparation is used only as part of complex therapy);
• Pancreatitis, which developed as a result of injuries or surgical interventions;
• Pancreatic necrosis;
• Primary bleeding that occurred against the background of hyperfibrinolysis (after surgery, various injuries, after childbirth and before them, with polymenorrhea);
• As a preventive measure of postoperative nonspecific mumps;
• Edema angioedema;
• Diagnostic examinations on the pancreas, as well as surgery;
• Signs of a shock state (eg, toxic, traumatic or hemorrhagic);
• Various tissue traumas (extensive and deep).

Why use the drug "Gordoks"? Indications for use include a deviation, such as coagulopathy, in which there is severe bleeding, as well as secondary hyperfibrinolysis (as an auxiliary therapy).

One can not help saying that this drug is actively prescribed for the purpose of preventive treatment of bleeding after surgery and pulmonary embolism.

Contraindications to the use of a medicinal product

In what cases can not use the drug "Gordoks"? The use of pancreatitis is most common, this is the main indication. With regard to contraindications, then they can include the following:

• Hypersensitivity of the patient or severe allergic reactions to the active substance of the drug (i.e., aprotinin);
• The first and third trimesters of pregnancy;
• The period of breastfeeding.

It should also be noted that the drug should be used with caution when stopping blood circulation due to the increased risk of kidney failure, deep hypothermia, and allergy (after previous therapy with aprotinin).

Medicinal product "Gordoks": instructions for use

With pancreatitis, as well as with other indications, the drug is injected slowly intravenously. The maximum rate of drug administration should be about 5-10 ml per minute.

During the infusion of the medication the patient should be only in the supine position on the back. The drug must be administered exclusively through the trunk veins. And use them for the introduction of other means is strictly prohibited.

In view of the fact that after using the medication there is a high risk of developing anaphylactic and allergic reactions, a trial volume of 1 ml (or 10 thousand KIE) is required for all patients 10 minutes before the introduction of the basic dosage. If after this, no negative reactions are not followed, then a therapeutic dose of medication is administered.

It should also be noted that it is possible to use histamine blockers H1 and H2 receptors for ¼ hour before the infusion of the drug. In any case, all standard emergency measures must be provided, which are aimed at treating an allergic or anaphylactic reaction.

For adults, the drug in question is recommended to be administered intravenously at the initial dosage, which is 1-2 million KIE. Do this slowly, for a quarter of an hour after the onset of anesthesia, and before sternotomy.

After completion of bolus administration of the drug, the patient is infused (at a rate of 250-500 thousand KIU per hour) until the end of the operation. The total amount of administered aprotinin throughout the course should not be above 7 million KIE.

People with impaired renal function, as well as elderly patients, do not need to adjust the dosage.

Side effects of the drug

What side effects does the drug "Gordoks" have, the indications, the contraindications of which have been described above?

As practice shows, patients who receive aprotinin for the first time do not face the development of anaphylactic or allergic reactions. With regard to re-introduction of the drug, the incidence of side effects increases to 5%. Especially often this happens in the event that such use of the drug was carried out within 6 months.

If the remedy is used more than 6 months later, the possible risk of developing anaphylactic and allergic reactions is approximately 0.9%.

The risk of serious adverse events increases significantly if aprotinin has been used more than two times in six months.

If no signs of allergic reactions were observed during the repeated use of the drug, the subsequent use of the drug can easily lead to the development of undesirable events, even with a fatal outcome.

Signs of anaphylactic and allergic reactions after use of the drug can manifest itself in the form of various disorders from the digestive tract, cardiovascular and respiratory systems, as well as skin.

In case of side effects, the use of the medicine should be immediately canceled. It is also necessary to ensure that all urgent standard interventions are carried out (eg, infusion therapy, epinephrine, epinephrine, corticosteroids).

So what are the undesirable effects that appear after using Gordox? Application in ophthalmology, therapy and veterinary medicine can cause the following deviations:

• Allergy: anaphylactic, anaphylactoid and allergic reactions, anaphylactic shock (may be fatal).
• Cardiovascular system: thrombosis, ischemia, pericardial effusion, myocardial infarction, thrombosis or coronary artery occlusion, pulmonary embolism and arterial thrombosis, which can occur with abnormalities of vital organs such as the lungs, kidneys and brain.
• The system of hematopoiesis: coagulopathy, including DIC-syndrome.
• Urinary system: impaired renal function and renal failure.
• Local adverse reactions: thrombophlebitis, reactions in the field of infusion or injection.

Special instructions for the use of the medicinal product

Now you know how to use such a medical tool as "Gordoks." Instructions for use in pancreatitis and other diseases was presented just above. However, before starting treatment with this drug, it is recommended to conduct skin tests that will determine the individual sensitivity of the person to the active agent of the drug (i.e., aprotinin).

If a history of allergic reactions were indicated, then before the therapy, the patient should take SCS and histamine blockers of H1-receptors.

If such abnormalities as hyperfibrinolysis and DIC-syndrome occur, the drug should be used only after these phenomena have been completely eliminated. The same applies to those cases when the patient has a preventive effect of heparin.

Very carefully considered medicine is prescribed for those patients who received muscle relaxants for several days before the start of therapy.

The composition of the drug "Gordoks" is benzyl alcohol. In this regard, its maximum volume per day should not exceed 90 mg per kg of body weight.

The drug "Gordoks" is not a substitute for such a drug as "Heparin".

After the ampoule with the solution has been opened, it should be used immediately. During re-use of the drug, it is prohibited to administer the drug from an open container.

It is extremely undesirable to mix the drug "Gordoks" with other medicines.

Can I administer the drug to a pet?

Is it permissible to introduce the drug "Gordoks" to dogs and cats? Use in animals is allowed. However, the dosage of the drug should be determined only by the veterinarian and only after an ultrasound examination of the abdominal cavity of the pet.

How correctly to enter "Gordoks"? The use of this medication in cats and dogs should be extremely cautious. This is due to the fact that the medication in question is allergenic.

The drug is administered intravenously via a special catheter. It can also be administered subcutaneously, in the area of the so-called "scab". It should be noted that intravenous infusions should be performed in the first two days of pancreatitis therapy. And only after the domestic pet can take food without vomiting, the medicine can be injected into the withers for another 5-7 days.

What should be the dosage when treated with Gordoks? The use in dogs of medium size and weight (about 15 kg) implies the introduction of a drug in a volume not exceeding 10 thousand KIE (three times a day). With regard to cats (weighing about 5 kg), the dosage should be 5 thousand KIE (pre-recommended to consult with a veterinarian).

To administer the drug through the dropper, the contents of the ampoule are collected in a syringe, and then the skin of the animal is pulled back and the needle is carefully guided into the subcutaneous space. In this case, the medicine is slowly squeezed out of the syringe.

Reviews about the drug

According to the reviews of therapists and veterinarians, the drug "Gordoks" quite effectively and quickly treats chronic as well as acute pancreatitis. In addition, he is able to stop any bleeding.

The only drawback of this medication is a huge number of side effects that can even lead to death. Therefore, use this drug should only be indicated by the indications and only by the prescribing doctor's appointment. Moreover, during treatment with this remedy, the patient must always be under the strict supervision of his doctor.