Bismuth tricalcium dicitrate - antiulcer

Bismuth tricalium dicitrate (trade name - drug "De-Nol") is an effective antiulcer drug with pronounced bactericidal activity against microorganisms of the Helicobacter pylori species. In addition, this drug has antacid, anti-inflammatory and astringent effects. The administration of this agent several times improves the protective characteristics of the mucous surface of the gastrointestinal tract, forming a special insoluble coating directly on the site of the ulcer. Also, bismuth tricium dicitrate increases the resistance of the gastric and intestinal membrane to the negative effects of enzymes, pepsin and hydrochloric acid, increases mucus production, bicarbonate secretion and prostaglandin type E synthesis. In addition to all of the above, experts note its ability to stimulate the activity of cytoprotective mechanisms.

As for the pharmacokinetics of this antiulcer, as a result of its course use, equilibrium concentrations in the blood are reached after four to five days, and the half-life is about five days. In this case, the fully active component is excreted from the body only twelve weeks after the start of the administration of such a drug as bismuth tricalcium dicitrate. Analogues of this drug - capsules "Bismay", "Desmol" and "Novobismol" - have a similar mechanism of action.

This antiulcer drug is produced mainly in the form of ordinary coated medicinal dragees. Take the tablets "De-Nol" (bismuth titanium dicitrate), the price of which is very affordable, the manufacturer recommends only for the treatment of ulcers of the duodenum or stomach. People suffering from chronic gastritis should also start taking this medication regularly. In addition, bismuth titrate dicitrate will quickly help in case of dyspepsia, not associated with organic gastrointestinal diseases.

Take this antiulcer drug doctors categorically prohibit in severe forms of violations of kidney function, as well as during pregnancy. The increased sensitivity and the period of feeding of the newborn baby with a breast are similarly included in the list of strict contraindications. Patients who have not reached the age of twelve, also should not start taking drugs that include bismuth tricalium dicitrate. In addition, it should always be remembered that in people with various kinds of abnormalities in kidney function, as a result of prolonged use of high dosages of this drug, the development of encephalopathy is possible.

If we consider the most common adverse reactions, the appearance of which may be caused by the use of this antiulcer drug, then in the first place, one should distinguish vomiting, nausea and diarrhea. In addition, there is a rather high risk of skin rash, itching, hyperemia of the skin and angioedema.