Analogues of "Xarelto": prices, instructions for use

One of the drugs that belongs to the pharmacological group of anticoagulants is the drug Xarelto. This drug inhibits factor Xa, and it, in turn, is a component of the prothrombin activator and one of the components that provide timely blood clotting (such properties are possessed by analogues of "Xarelto").

To date, many vain attempts have been made to withdraw the drug, which will have a similar effect and at the same time have a minimum of side effects. After numerous laborious efforts, a worthy analogue appeared - the Pradax preparation. This drug is the only substitute that can be fully used in place of Xarelto. Its characteristics are almost identical to the above, the only difference is the content of the active substance, which in both preparations is rivaroxaban.

Pharmacodynamics

All analogues of "Xarelto" have a similar action. The only thing they differ in is the quantitative and qualitative index of side effects. The only worthy analogue of this drug, which has a similar effect to it, is the preparation of Pradax.

This drug and its Russian analogue "Xarelto" are direct, highly selective drugs that slow down the effect of factor Xa, that is, inhibit it. This drug has a high bioavailability when taken orally, so the enteral route of admission for it is the main one.

The central role in the cascade of the coagulation system is the activation of factor X with subsequent biotransformation of factor Xa with the help of internal and external coagulation pathways.

Indications

As a rule, analogues of "Xarelto" and the drug itself are used in the following situations:

• Prevention and prevention of stroke.
• Prevention and relief of systemic embolism.
  
  (In similar cases, this drug is indicated in patients with atrial fibrillation, which has a non-valent origin.)

• Elimination or prevention of blockage of deep veins by blood clots.
• Prevention of recurrence of pulmonary embolism.

The Pradax preparation, which is an analogue, is also indicated for the prevention of venous thromboembolic complications in patients who underwent surgery to replace one of the joints of the lower limb.

Contraindications

Any Russian analogue of "Xarelto" has the following contraindications (they may differ, but only to a small extent):

• Hypersensitivity or the risk of allergic reactions to substances contained in this drug;
• Active bleeding, which have significant informative value during clinical examination (for example, intracavitary bleeding or hemorrhages in the brain);

• Situations in which there is an increased risk of volumetric bleeding, for example, with active ulcerative processes in the gastrointestinal tract;
• Drug therapy with drugs that have similar properties - preventing coagulation;
• When using non-fractional heparin in the dosage necessary for the satisfactory functioning of the catheter;
• Various liver diseases, the development of which can provoke bleeding of different etiologies;
• Absolutely all analogues of "Xarelto" are contraindicated in patients with renal insufficiency occurring in any phase;
• Lactose intolerance, insufficient galactose content in the body;
• Pregnancy and lactation;
• Also on this drug and various analogues of "Xarelto" there is an age limit of 18+.

The category of persons who can take this medication with caution and under the supervision of a specialist

With caution and under the supervision of a doctor recommends the use of "Xarelto" instructions for use (analogues also) in the following cases:

• Treatment of patients who have an increased risk of bleeding;
• The recently transferred ulcerative diseases, predisposing to relapse;
• Treatment of renal failure of varying degrees in combination with drugs that increase the content of rivaroxaban in the patient's body;
• Patients who are being treated with drugs that can increase hemostasis;
• Drugs that are capable of increasing the level of rivaroxaban, for example, antifungal azole agents;
• This preparation and the analogue of the "Xarelto" tablets are contraindicated in patients with HIV infection if they took various protease inhibitors of this virus for a short time.

Use during pregnancy and lactation

To date, it is not exactly established how the "Xarelto", analogues of the drug affect the effectiveness and safety of treatment in pregnant women.

Experiments that have been conducted on animals in laboratories have demonstrated a marked toxicity of the active substance of this drug on the future mother's body, since the drug leads to a pronounced reproductive toxicity of the female body.

According to laboratory findings, the drug "Xarelto", an analogue that is similar to it for pharmacological action, has the ability to penetrate the placenta, so this drug is contraindicated.

Also, during the application of Xarelto, women should not forget about effective contraceptive measures, since conception, which accompanies the course of this medication, can negatively affect the fetal development of the fetus.

Objective judgments about how the use of this drug affects the lactation period, at the moment does not exist, but laboratory studies in experimental animals suggest that the active substance - rivaroxaban - has the ability not to metabolize and excrete with breast milk. Therefore, during breastfeeding it is worth not to use this medication.

Based on the data provided by laboratory studies, it can be said that rivaroxaban does not affect the ability of the sexually mature organism to create viable offspring in rats, but in humans such experiments were not conducted.

Metabolism and the ways of excretion

With enteral administration, there are three ways of excretion, which correspond to one third of the total amount of non-metabolized drug:

• Excretion in urine;
• Excretion with feces;
• Excretion by direct excretion of the kidneys (in this case, substances are practically not metabolized and are excreted unchanged).

Biotransformation of rivaroxab is carried out through mechanisms that do not depend on the cytochrome system.

The main pathways of metabolism are the oxidation of the morpholine group and also the decomposition of amide bonds with water.

Studies conducted in vitro allow us to judge that rivaroxaban is the basis for P-glycoprotein and protein, which provides resistance to breast cancer.

As a rule, the excretion of metabolites is carried out for 5-9 hours.

Side effects

As the instruction for the use says: analogues of "Xarelto" or the drug itself should be taken only according to the doctor's prescription. The instruction itself describes in detail the dosages of the drug or its analogs. Be sure to read the instructions before use!

Below, all the undesirable processes and reactions that had the "Xarelto" preparation, analogues, were reflected. The price of tablets - from 900 rubles. This is inexpensive, given that most side effects are exceptions to the rules.

• Side effects that were observed during the check of the circulatory and lymphatic system are anemia and thrombocythemia, which occur infrequently.
• Tachycardia is the only undesirable reaction when taking this medication.
• Hemorrhages.

Here such indicates the contraindications to the drug "Xarelto" instruction.

Analogues of this drug can cause disorders in the digestive tract: bleeding, localized pain, dyspepsia, sometimes - dry mouth.

Because of the introduction of rivaroxaban, local reactions can occur: increased body temperature, swelling at the injection site with the parenteral route, weakness and malaise.

The emergence of these processes contribute to the drug "Xarelto", analogs. The price of this drug, as a rule, is standard for all pharmacy chains.

Methods of application and dosage

Detailed information on the correct reception can be given absolutely any to the drug "Xarelto" instruction. Analogues of this drug in this plan are not fundamentally different.

This drug is available in tablet form, so the pill is taken enterally. If the patient for some reason can not swallow the pill - it can be crushed and mixed with a suitable liquid (tea, water).

After taking this medication, food intake should be followed immediately.

Overdose

If the "Xarelto" intake is not adhered to, an overdose is possible, which, as a rule, is treated symptomatically, since this drug does not have a specific antidote.

In order to reduce the adsorption of this drug in the small intestine, any sorbent, for example, activated charcoal, can be used. Also for the prompt removal of metabolites, it is necessary to provide forced diuresis, which is carried out by using a lot of fluid and using diuretics.

Price list

Depending on the manufacturer, the price of the drug "Xarelto" ranges from 899.00 rub. For 10 tablets, which contain 10 mg of active ingredient, to 1,740.49 rubles.

The package, in which 30 tablets, can be purchased for 3300.00 rub.

The largest package contains 100 capsules, its cost is 8600 rubles.

The price policy of the Pradax preparation depends on the quantitative content of the active substance in one capsule:

• 75 mg - 716.00 rubles;
• 110 mg - 1574.00 rubles;
• 150 mg - 1676.00 rubles.