Reviews: "Alpha Normix". Description, composition and instructions for use of the drug

Near to the person and in itself billions of bacteria live. Some people need it for the normal functioning of the body, and without others, to put it mildly, one could do absolutely. Whole colonies of pathogenic microorganisms constantly test the human immune system for strength. To combat dangerous bacteria that threaten the health and life of people, scientists have developed special antibacterial drugs - antibiotics. Some of these medicines are designed to control individual microorganisms, others are broad-spectrum drugs (at least, experts leave such reviews). "Alpha Normix" is one of such preparations.

Forms of release

Reviews about "Alpha Normix" are mostly positive direction, since this antibacterial agent is produced in several forms.

For adult patients (over 12 years of age), as a rule, health workers recommend to take a tablet form. The manufacturer produces honey in the form of convex round tablets with a pink color. Packing - blisters (12 tablets each). One bundle can contain 1 or 3 blisters.

Small patients (up to 12 years of age) are most often prescribed for treatment a suspension, which is prepared from granules (the second form of the release is "Alpha Normix"). The granules are orange in color. The prepared suspension smells of cherries, and the taste has a corresponding odor. This form of the drug is packaged in vials (the color of the glass is dark), in each - 5 ml of the substance. To measure the desired dose, a measuring cup is included in the kit.

Composition of the medicinal product

The main active ingredient of the medication is rifaximin. The volume of its content in one tablet is 200 mg. A number of compounds, including propylene glycol and glycerol palmitostearate, act as additional components.

If the drug "Alpha Normix" (application, reviews - all this will be described below) is assigned to reception as a suspension, then in ready-to-eat 5 ml of the solution contains 100 mg of rifaximin. The medicament includes a lot of auxiliary components, including the "wild cherry" flavor.

Pharmacodynamics of the preparation

The main active component (this is confirmed by medical reviews) "Alpha Normix" is contained in the alpha form, which allows it to bind β-subunits of the DNA-dependent enzyme of the pathogenic microorganism. In other words, rifaximin inhibits the synthesis of proteins and RNA in bacterial cells. Since this phenomenon is irreversible, the microorganism perishes.

A wide range of antimicrobial effects can effectively fight the overwhelming majority of pathogenic bacteria that cause the development of infections in the gastrointestinal tract: gram-negative and gram-positive, aerobic and anaerobic.

The influence of "Alpha Normix" is such that the pathogenic intestinal bacterial load is significantly reduced. The drug suppresses the production of ammonia and other toxic compounds by bacteria. For patients suffering from any liver disease accompanied by abnormalities in detoxification processes, this is very important, since ammonia and other toxins are involved in the pathogenesis and development of the symptoms of hepatic encephalopathy.

Also, reviews of the Alpha Normix tablets from specialists indicate that the honey drug reduces the high proliferation of bacteria (observed with intensive growth of microorganisms in the intestine), reduces their presence in the diverticula of the colon, suppresses the inflammatory process in the area of the diverticular bag. In addition, rifaximin reduces the antigenic stimulus (if present) and significantly reduces the likelihood of developing infectious complications in surgical operations in the colorectal zone.

Pharmacokinetics

When you take the antibiotic "Alpha Normix" inside its absorbability is less than 1%, i.e. this medication has intestinal effect, since very high concentrations of the active substance accumulate in the digestive tract. The administration of therapeutic doses does not lead to the appearance of the drug in the blood plasma or it is detected in very low concentrations.

The maximum concentration of antibiotic in fecal masses is reached within 3 days of therapy with a volume of a daily total dose equal to 800 mg.

Indications for the use of antibacterial medication

The drug is used to treat rifaximin-sensitive GI infections. Medical workers prescribe it for admission with too intensive growth of pathogenic microflora in the intestines, travelers' diarrhea, liver encephalopathy and uncomplicated diverticular diseases of the colon. Apply "Alpha Normix" for colitis.

The doctors' reviews highly appreciate the effectiveness of this antibiotic in acute gastrointestinal infections and chronic inflammation of the intestine.

Contraindications, consequences of overdose

Individual sensitivity to rifaximin, any other rifamycins, or one of the auxiliary components is a sufficient reason for refusing to take the medication. In addition, "Alpha Normix" (tablets) reviews, the description in the instructions prohibits taking with intestinal obstruction of all kinds, with ulcers in the intestine.

As for exceeding the permissible dose, no more than 2400 mg of rifaximin can be overdosed during the day. If, for some reason, the drug was taken in a volume much higher than recommended, it is necessary to do a gastric lavage and then take measures according to the manifested symptoms.

Side effects

Due to low absorption (about 1%), systemic undesirable effects, as a rule, do not develop. At least, the patients are not informed about the "Alpha Normix" reviews. Real responses of doctors report individual cases of development of weak and moderate negative manifestations from the gastrointestinal tract, such as dyspepsia, nausea, vomiting, intestinal colic, abdominal pain. In most cases, all these manifestations abruptly passed without the need to cancel the drug or change the dosage.

In very rare cases, it is possible to develop dermatological manifestations similar to urticaria (urticaria). With a high degree of probability such manifestations are dictated by individual intolerance to therapy.

However, if the patient, in addition to the main gastrointestinal disease, had any accompanying health problems, that is, the probability of an increase in blood pressure, development of tachycardia, dizziness, dyspnea, headaches. It is possible to develop feverish conditions, heartburn, and Quincke's edema.

If any serious side effects develop, consultation with the treating doctor is mandatory.

Dosages and methods of administration

As mentioned earlier, tablets and granules are the existing forms that consumers are offered by the manufacturer Alfa Normix. Feedback on the use of the drug, on effective dosages and methods of use differ for tablets and suspensions.

The first (tablet form) is taken orally, without chewing and not breaking. For patients who have reached the age of 12, usually the standard treatment regimen prescribes to take 1 tablet every 8 hours, or every 2 hours for 2. The course of therapy is determined by the doctor, but usually should not last longer than 7 days. Repeated course is allowed after 1 month.

As for granules, the suspension is first prepared (the water is poured to the 1 st mark, the vial is shaken vigorously, the water is added to the next level), and then the required volume (i.e., appointed by the doctor) is measured by means of a measuring cup.

The permissible total dose per day for adult patients (age over 12 years) may range from 600 to 1200 mg of the drug. This in practice corresponds to a volume of 10-20 ml with a frequency of reception 2-3 times during the day. For younger patients (6-12 years), the daily dosage is allowed in a volume of 400 to 800 mg. The suspension is taken twice a day in a volume of 10-20 ml. For small patients (the age range of 2-6 years), the total volume of antibiotic per day is from 200 to 600 mg. It is recommended to take 5-10 ml at a frequency of 2 to 3 times during the day. The therapeutic course should not last more than 1 week.

Special instructions

Sufficiently long-term use of this antibacterial agent or damage to the intestinal mucosa and, as a consequence, absorption of small amounts of the drug, can cause urine staining in a reddish color. Patients often leave such reviews. "Alpha Normix" contains rifaximin, which, like, however, the bulk of antibacterial agents of this species (rifamycin), has a reddish, orange-tinged color. This is the reason why the color of urine changes.

If the need to take "Alpha Normix" arose during the period of gestation, it is only permissible to do so in emergency and with direct monitoring of the health status of the woman by the attending physician. The same applies to lactating women.

Interaction with other medications

There are no reviews on the interaction with other medicinal products by specialists. "Alpha Normix" is characterized by very low systemic absorption (less than 1%), so the probability of any reactions at the system level is very small.

Reviews about "Alpha Normix"

Quite a lot of patients after treatment leave a review about the antibiotic "Alpha Normix" in the sense that the drug has proven itself in the treatment of chronic bowel diseases. Many also write about the fact that the drug is very, very effective as a remedy in emergency cases. According to medical experts, "Alpha Normix" - the drug is quite strong. For this reason, it will not be superfluous after the end of therapy with antibiotics to restore normal microflora in the intestines to drink a course of probiotics.

I would like to say that the use of such powerful antibiotics as "Alpha Normix" should be appointed by the treating doctor, who will assess the state of health of his patient, take into account all accompanying diseases and take the only correct and effective decision.